Advanced Paternal Age and the Risk of Schizophrenia: A Literature Review

Bajwa, Ghulam Murtaza; Hasija, Deepa; Jadapalle, Sree Latha Krishna; Ghaffar, Sadia; Badr, Amel

doi:10.3928/00485713-20110119-09

Cited by 2 publications

(3 citation statements)

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“…In most western sociaties the average father's age is increasing, reflecting changes in professional and social life. The literature shows that in the England and Wales of 1993-2003, the rate of the older paternal age (35-54 years) increased from 25 percent to 40 percent, and the mean paternal age increased from 29.2 years to 32.1 year [6]. Several cohort studies from Israel, America, Denmark, Sweden proved strong evidence of a link between increased paternal age to schizophrenia risk in offspring.…”

Section: Introductionmentioning

confidence: 99%

“…This raises the idea that sperm cell division occurs during male life results in high mutation rates and cytogenic abnormalities in older male sperm. In addition, exposure to heat can also cause an increase in the mutation of spermatozoa [6].…”

Section: Introductionmentioning

confidence: 99%

“…Hypermethylated repetitive and elements in the genome are often not efficiently reprogrammed, this may lead to de novo structural mutations, which are often associated with repetitive of DNA sequences motifs, may be subjected to differential epigenetic reprogramming, associating both mutagenic and epigenetic processes in the phenotypic manifestations of increased paternal age [6].…”

Section: Introductionmentioning

confidence: 99%

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Relationship of Advanced Paternal Age and Onset of Schizophrenia

Widyastuty

Gultom

Husada

2019

SMJ

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Background: Increased paternal age has been associated with an increased risk of spontaneous abortion, premature birth, infant mortality, congenital malformations, childhood cancer, epilepsy, autism, bipolar and schizophrenia in offspring. The biological mechanisms behind this relationship are not known but may be associated with de novo mutations and epigenetic changes in male cells with short and long term health consequences for their offspring. Males are responsible for most of the new mutations in the gene group, to the permanent distribution of reproductive cells and the number of mutations increases significantly with age. Objective: The aim of the study to determine the correlation between paternal age and onset of schizophrenia. Method: This study was correlation analysis with cross sectional approach with The subject is 92 schizophrenia patient. Analysis of the data using statistical test that is chi-square. Result: the study findings showed there was significant correlation between paternal age with schizophrenic aged onset of 0.001 (p <0.05).

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship of Advanced Paternal Age and Onset of Schizophrenia

Widyastuty

Gultom

Husada

2019

SMJ

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The other face of advanced paternal age: a scoping review of its terminological, social, public health, psychological, ethical and regulatory aspects

Couture

Delisle

Mercier

et al. 2020

Human Reproduction Update

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BACKGROUND There is a global tendency for parents to conceive children later in life. The maternal dimension of the postponement transition has been thoroughly studied, but interest in the paternal side is more recent. For the moment, most literature reviews on the topic have focused on the consequences of advanced paternal age (APA) on fertility, pregnancy and the health of the child. OBJECTIVE AND RATIONALE The present review seeks to move the focus away from the biological and medical dimensions of APA and synthesise the knowledge of the other face of APA. SEARCH METHODS We used the scoping review methodology. Searches of interdisciplinary articles databases were performed with keywords pertaining to APA and its dimensions outside of biology and medicine. We included scientific articles, original research, essays, commentaries and editorials in the sample. The final sample of 177 documents was analysed with qualitative thematic analysis. OUTCOMES We identified six themes highlighting the interdisciplinary nature of APA research. The ‘terminological aspects’ highlight the lack of consensus on the definition of APA and the strategies developed to offer alternatives. The ‘social aspects’ focus on the postponement transition towards reproducing later in life and its cultural dimensions. The ‘public health aspects’ refer to attempts to analyse APA as a problem with wider health and economic implications. The ‘psychological aspects’ focus on the consequences of APA and older fatherhood on psychological characteristics of the child. The ‘ethical aspects’ reflect on issues of APA emerging at the intersection of parental autonomy, children’s welfare and social responsibility. The ‘regulatory aspects’ group different suggestions to collectively approach the implications of APA. Our results show that the field of APA is still in the making and that evidence is lacking to fully address the issues of APA. The review suggests promising avenues of research such as introducing the voice of fathers of advanced age into the research agenda. WIDER IMPLICATIONS The results of this review will be useful for developing policies and preconception health interventions that consider and include prospective fathers of advanced age.

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Advanced Paternal Age and the Risk of Schizophrenia: A Literature Review

Cited by 2 publications

References 24 publications

Relationship of Advanced Paternal Age and Onset of Schizophrenia

Relationship of Advanced Paternal Age and Onset of Schizophrenia

The other face of advanced paternal age: a scoping review of its terminological, social, public health, psychological, ethical and regulatory aspects

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