Advanced Preparation Makes Research in Emergencies and Isolation Care Possible: The Case of Novel Coronavirus Disease (COVID-19)

Brett-Major, David M.; Schnaubelt, Elizabeth; Creager, Hannah M.; Lowe, Abigail E.; Cieslak, Theodore J.; Dahlke, Jacob M.; Johnson, Daniel W.; Fey, Paul D.; Hansen, Keith; Hewlett, Angela; Gordon, Bruce Geoffrey; Kalil, André C.; Khan, Ali S.; Kortepeter, Mark G.; Kratochvil, Christopher J.; Larson, Lu Ann; Levy, Deborah A.; Linder, James; Medcalf, Sharon; Rupp, Mark E.; Schwedhelm, Michelle; Sullivan, James; Vasa, Angela; Wadman, Michael C.; Lookadoo, Rachel; Lowe, John J.; Lawler, James V.; Broadhurst, M. Jana

doi:10.4269/ajtmh.20-0205

Cited by 13 publications

(8 citation statements)

References 9 publications

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“…The Coronavirus disease 2019 (COVID-19) caused a high alert because of its devastating effects on the respiratory system. The high infection risk led the World Health Organization (WHO) to declare the pandemic outbreak [1]. Starting on 9 March 2020, the Italian Prime Minister, after the virus spread, ordered the implementation of physical distancing measures.…”

Section: Introductionmentioning

confidence: 99%

Psychological Impact of the Quarantine-Induced Stress during the Coronavirus (COVID-19) Outbreak among Italian Athletes

Cagno

Buonsenso

Baralla

et al. 2020

IJERPH

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The 2019 Coronavirus (COVID-19) outbreak caused home confinement, as well as training and sport competitions withdrawals. The prolonged inactivity impact, and lack of in-person interactions among teammates-coaches, could negatively affect athletes. Total of 1508 self-selected Italian athletes, 338 children (aged 10.52 ± 1.31), 499 adolescents (aged 14.17 ± 1.13), and 671 adults (aged 27.59 ± 10.73), completed the Impact of Event Scale (IES-8, IES-15, and IES-R, respectively). Differences by gender, type of sport (individual vs. team), and competitive level (elite vs. amateur) were examined. One-way ANOVAs showed, in adults, significant differences between genders for perceived stress impact total score (TS; p = 0.017) and avoidance behavior, with higher scores in women (p = 0.045). Between individual and team sport, significant differences were found in TS (p = 0.038) and hyperarousal (p = 0.030), with higher results in individual. Adult elite athletes showed significantly higher scores in hyperarousal (p = 0.020) than amateurs. Significant differences were found between gender in adolescents for avoidance (p = 0.011), and between competitive levels in children, for intrusion (p = 0.020). These evidences may raise awareness on distress effects of COVID-19 lockdown among athletes and suggested applying specific well-being protocols during the activity resumption, considering gender, type of sport, and competitive level.

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Section: Introductionmentioning

confidence: 99%

Psychological Impact of the Quarantine-Induced Stress during the Coronavirus (COVID-19) Outbreak among Italian Athletes

Cagno

Buonsenso

Baralla

et al. 2020

IJERPH

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“…There are many other national and international challenges toward effect rapid response. For example, Brett-Major et al (2020) highlight the importance of striking ethics and investigative committees in an effort to provide opportunities to identify challenges posed against risk management beyond the development of a vaccine. Moreover, as it has been mentioned regarding diagnostics above, rapid research initiatives also face operational challenges that include the collection of standardized data from participating organizations worldwide, identifying scholarly journals that could published results in a timely manner, and managing pre-existing research efforts that could delay authors' ability to finalize manuscripts (Hurtado et al 2018).…”

Section: The Global Contextmentioning

confidence: 99%

Canada’s rapid research response to the COVID-19 pandemic

Stojanovic

2021

cjils-rcsib

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This study assesses the nature of Canada’s rapid research response through term and keyword bibliometric analysis. The following asks: What are the major areas of COVID-19 rapid research output conducted in Canada during the first five and half months of 2020, and how can the results of this analysis inform future accelerated research efforts toward an effective response to infectious disease emergencies? The results suggest that infection prevention, epidemiology, therapeutics, and public health strategies were among the top-producing research areas in Canada during the onset of the pandemic. Moreover, the analysis reflects gaps in the literature addressing diagnostics and vaccine development.

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“…Overcoming barriers to the establishment of prospective observational cohort studies during a pandemic requires strategic planning and multidisciplinary effort [ 5 ]. Academic medical centers with the ability to leverage available resources, identify shared common goals across stakeholders, and adapt to changing clinical and research needs may be at an advantage [ 6 ]. Unfortunately, vulnerable populations such as pregnant women and newborns are at increased risk of exclusion from COVID-19 research and many have advocated on their behalf to be included in key clinical trials and observational studies [ 7 – 9 ].…”

Section: Introductionmentioning

confidence: 99%

Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled

Shook

Shui

Boatin

et al. 2020

BMC Med Res Methodol

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Background: Collection of biospecimens is a critical first step to understanding the impact of COVID-19 on pregnant women and newborns-vulnerable populations that are challenging to enroll and at risk of exclusion from research. We describe the establishment of a COVID-19 perinatal biorepository, the unique challenges imposed by the COVID-19 pandemic, and strategies used to overcome them. Methods: A transdisciplinary approach was developed to maximize the enrollment of pregnant women and their newborns into a COVID-19 prospective cohort and tissue biorepository, established on March 19, 2020 at Massachusetts General Hospital (MGH). The first SARS-CoV-2 positive pregnant woman was enrolled on April 2, and enrollment was expanded to SARS-CoV-2 negative controls on April 20. A unified enrollment strategy with a single consent process for pregnant women and newborns was implemented on May 4. SARS-CoV-2 status was determined by viral detection on RT-PCR of a nasopharyngeal swab. Wide-ranging and pregnancy-specific samples were collected from maternal participants during pregnancy and postpartum. Newborn samples were collected during the initial hospitalization. Results: Between April 2 and June 9, 100 women and 78 newborns were enrolled in the MGH COVID-19 biorepository. The rate of dyad enrollment and number of samples collected per woman significantly increased after changes to enrollment strategy (from 5 to over 8 dyads/week, P < 0.0001, and from 7 to 9 samples, P < 0.01). The number of samples collected per woman was higher in SARS-CoV-2 negative than positive women (9 vs 7 samples, P = 0.0007). The highest sample yield was for placenta (96%), umbilical cord blood (93%), urine (99%), and maternal blood (91%). The lowest-yield sample types were maternal stool (30%) and breastmilk (22%). Of the 61 delivered women who also enrolled their newborns, fewer women agreed to neonatal blood compared to cord blood (39 vs 58, P < 0.0001).

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Advanced Preparation Makes Research in Emergencies and Isolation Care Possible: The Case of Novel Coronavirus Disease (COVID-19)

Cited by 13 publications

References 9 publications

Psychological Impact of the Quarantine-Induced Stress during the Coronavirus (COVID-19) Outbreak among Italian Athletes

Psychological Impact of the Quarantine-Induced Stress during the Coronavirus (COVID-19) Outbreak among Italian Athletes

Canada’s rapid research response to the COVID-19 pandemic

Rapid establishment of a COVID-19 perinatal biorepository: early lessons from the first 100 women enrolled

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