Advanced Research on Animal Venoms in China

Lai, Ren; Lu, Qiumin

doi:10.3390/toxins15040272

Cited by 2 publications

(1 citation statement)

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“…Venomous organisms have undergone extensive evolution, resulting in the development of unique zootoxins that serve crucial roles in survival, sustenance, and defense [ 8 , 9 , 10 , 11 , 12 , 13 ]. These animal toxins harbor a diverse array of peptides with multifunctional and practical properties, including peptides with antibacterial [ 14 , 15 ], antithrombotic [ 16 , 17 ], analgesic [ 18 , 19 ], antioxidant [ 20 , 21 ], antihypertensive [ 22 , 23 ], neuroactive [ 24 , 25 ], and regulatory effects [ 26 , 27 ].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Poeciguamerin, a Peptide with Dual Analgesic and Anti-Thrombotic Activity from the Poecilobdella manillensis Leech

Wang

Chen

et al. 2023

IJMS

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When Poecilobdella manillensis attacks its prey, the prey bleeds profusely but feels little pain. We and other research teams have identified several anticoagulant molecules in the saliva of P. manillensis, but the substance that produces the paralyzing effect in P. manillensis is not known. In this study, we successfully isolated, purified, and identified a serine protease inhibitor containing an antistasin-like domain from the salivary secretions of P. manillensis. This peptide (named poeciguamerin) significantly inhibited elastase activity and slightly inhibited FXIIa and kallikrein activity, but had no effect on FXa, trypsin, or thrombin activity. Furthermore, poeciguamerin exhibited analgesic activity in the foot-licking and tail-withdrawal mouse models and anticoagulant activity in the FeCl3-induced carotid artery thrombosis mouse model. In this study, poeciguamerin was found to be a promising elastase inhibitor with potent analgesic and antithrombotic activity for the inhibition of pain and thrombosis after surgery or in inflammatory conditions.

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