This article begins by analyzing the application characteristics, component structure, and advantages of the Django framework. With Python's widespread use in web development, choosing an efficient web development framework is crucial. Django, as an open-source framework, has become the preferred choice for Python web development due to its simplicity, comprehensive components, and high development efficiency. This article delves into the methods of application design and implementation based on Django, including the application architecture design using the MTV pattern, model and database design, and views and template design, to guide the practical application of the Django framework in web development. Finally, it summarizes the efficiency and advantages of developing web applications with the Django framework, providing a theoretical basis for framework selection.