Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Lu, Hang; Wang, Jiale; Li, Jun; Gao, Bing; He, Bingfang

doi:10.1002/mabi.202300141

“…SF is a natural high molecular weight fibrous protein extracted from silk through a degumming process . Possessing excellent flexibility, ductility, biocompatibility, biodegradability, and mechanical properties, SF is also susceptible to chemical modifications, making it an ideal material for the fabrication of microneedles …”

Section: Design Of Hmnsmentioning

confidence: 99%

“…62 Possessing excellent flexibility, ductility, biocompatibility, biodegradability, and mechanical properties, SF is also susceptible to chemical modifications, making it an ideal material for the fabrication of microneedles. 63 Despite its many advantages, pure SF microneedles are soluble in water, 64 necessitating modifications such as 2ethoxyethanol, semi-interpenetrating network (semi-IPN), CS, and methacryloyl groups to prepare water-insoluble microneedles for sustained drug release. For example, Yin et al 64 created a composite material by mixing 2-ethoxyethanol with SF and fabricated microneedles with controlled release mechanisms and excellent biocompatibility, offering prospects as a viable transdermal delivery system.…”

Section: Silk Fibroin (Sf)mentioning

confidence: 99%

Research Progress of Hydrogel Microneedles in Wound Management

Ji,

Zhan,

Qiu

et al. 2024

ACS Biomater. Sci. Eng.

1

0

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Microneedles are a novel drug delivery system that offers advantages such as safety, painlessness, minimally invasive administration, simplicity of use, and controllable drug delivery. As a type of polymer microneedle with a threedimensional network structure, hydrogel microneedles (HMNs) possess excellent biocompatibility and biodegradability and encapsulate various therapeutic drugs while maintaining drug activity, thus attracting significant attention. Recently, they have been widely employed to promote wound healing and have demonstrated favorable therapeutic effects. Although there are reviews about HMNs, few of them focus on wound management. Herein, we present a comprehensive overview of the design and preparation methods of HMNs, with a particular emphasis on their application status in wound healing, including acute wound healing, infected wound healing, diabetic wound healing, and scarless wound healing. Finally, we examine the advantages and limitations of HMNs in wound management and provide suggestions for future research directions.

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Designing Multifunctional Biomaterials via Protein Self‐Assembly

Solomonov,

Kozell,

Shimanovich

2024

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Protein self‐assembly is a fundamental biological process where proteins spontaneously organize into complex and functional structures without external direction. This process is crucial for the formation of various biological functionalities. However, when protein self‐assembly fails, it can trigger the development of multiple disorders, thus making understanding this phenomenon extremely important. Up until recently, protein self‐assembly has been solely linked either to biological function or malfunction; however, in the past decade or two it has also been found to hold promising potential as an alternative route for fabricating materials for biomedical applications. It is therefore necessary and timely to summarize the key aspects of protein self‐assembly: how the protein structure and self‐assembly conditions (chemical environments, kinetics, and the physicochemical characteristics of protein complexes) can be utilized to design biomaterials. This minireview focuses on the basic concepts of forming supramolecular structures, and the existing routes for modifications. We then compare the applicability of different approaches, including compartmentalization and self‐assembly monitoring. Finally, based on the cutting‐edge progress made during the last years, we summarize the current knowledge about tailoring a final function by introducing changes in self‐assembly and link it to biomaterials’ performance.

show abstract

Designing Multifunctional Biomaterials via Protein Self‐Assembly

Solomonov,

Kozell,

Shimanovich

2024

View full text Add to dashboard Cite

Protein self‐assembly is a fundamental biological process where proteins spontaneously organize into complex and functional structures without external direction. This process is crucial for the formation of various biological functionalities. However, when protein self‐assembly fails, it can trigger the development of multiple disorders, thus making understanding this phenomenon extremely important. Up until recently, protein self‐assembly has been solely linked either to biological function or malfunction; however, in the past decade or two it has also been found to hold promising potential as an alternative route for fabricating materials for biomedical applications. It is therefore necessary and timely to summarize the key aspects of protein self‐assembly: how the protein structure and self‐assembly conditions (chemical environments, kinetics, and the physicochemical characteristics of protein complexes) can be utilized to design biomaterials. This minireview focuses on the basic concepts of forming supramolecular structures, and the existing routes for modifications. We then compare the applicability of different approaches, including compartmentalization and self‐assembly monitoring. Finally, based on the cutting‐edge progress made during the last years, we summarize the current knowledge about tailoring a final function by introducing changes in self‐assembly and link it to biomaterials’ performance.

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Advanced Silk Fibroin Biomaterials‐Based Microneedles for Healthcare

Cited by 5 publications

References 78 publications

Research Progress of Hydrogel Microneedles in Wound Management

Research Progress of Hydrogel Microneedles in Wound Management

Designing Multifunctional Biomaterials via Protein Self‐Assembly

Designing Multifunctional Biomaterials via Protein Self‐Assembly

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