“…1,6 In addition, estimating prognosis for morbidity and mortality may help patients and their families understand the nature of illness and the reasons for a referral to supportive or palliative care in selected cases. 1,6 Many univariate predictors of poor prognosis in HF have been identified, including high New York Heart Association functional class, reduced left ventricular ejection fraction, abnormal right ventricular function, concomitant diastolic dysfunction, low peak oxygen consumption during cardiopulmonary exercise testing, and signs of reduced tissue perfusion (eg, low mean arterial pressure, renal dysfunction, and neurohormonal activation). 1,6,9 It is well known that comorbidities influence the pathophysiology, management, and prognosis of advanced HF, contributing to increased morbidity and mortality.…”