Advanced Techniques Using Contrast Media in Neuroimaging

Ferré, Jean–Christophe; Shiroishi, Mark S.; Law, Meng

doi:10.1016/j.mric.2012.07.007

Cited by 18 publications

(8 citation statements)

References 97 publications

(111 reference statements)

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“…While it was understood that Gd 3+ was the most effective paramagnetic ion for proton relaxation, other paramagnetic ions have been developed for use as MRI contrast agents, including Mn 2+ [ 32 ] and iron oxide compounds [ 33 ]. Today, contrast media are administered in about 25% of all MRI examinations, especially for the brain and spine, for MR angiography (MRA) and for MRI of the abdomen, breast and heart [ 34 – 36 ].…”

Section: Development and Characteristics Of Mr Contrast Agentsmentioning

confidence: 99%

25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives

et al. 2016

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In 1988, the first contrast agent specifically designed for magnetic resonance imaging (MRI), gadopentetate dimeglumine (Magnevist®), became available for clinical use. Since then, a plethora of studies have investigated the potential of MRI contrast agents for diagnostic imaging across the body, including the central nervous system, heart and circulation, breast, lungs, the gastrointestinal, genitourinary, musculoskeletal and lymphatic systems, and even the skin. Today, after 25 years of contrast-enhanced (CE-) MRI in clinical practice, the utility of this diagnostic imaging modality has expanded beyond initial expectations to become an essential tool for disease diagnosis and management worldwide. CE-MRI continues to evolve, with new techniques, advanced technologies, and novel contrast agents bringing exciting opportunities for more sensitive, targeted imaging and improved patient management, along with associated clinical challenges. This review aims to provide an overview on the history of MRI and contrast media development, to highlight certain key advances in the clinical development of CE-MRI, to outline current technical trends and clinical challenges, and to suggest some important future perspectives.FundingBayer HealthCare.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-015-0275-4) contains supplementary material, which is available to authorized users.

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Section: Development and Characteristics Of Mr Contrast Agentsmentioning

confidence: 99%

25 Years of Contrast-Enhanced MRI: Developments, Current Challenges and Future Perspectives

et al. 2016

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“…DCE-MRI is based on the acquisition of serial T1-weighted images before, during, and after administration of a gadolinium-based contrast agent. The resulting signal intensity-time curve can be used to extract quantitative information concerning fluid kinetics ( 21 , 22 ). Contrast enhancement is linearly correlated to the concentration of the contrast materials in both blood and tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of Arterial Deprivation on Growing Femoral Epiphysis: Quantitative Magnetic Resonance Imaging Using a Piglet Model

et al. 2015

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ObjectiveTo investigate the usefulness of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion MRI for the evaluation of femoral head ischemia.Materials and MethodsUnilateral femoral head ischemia was induced by selective embolization of the medial circumflex femoral artery in 10 piglets. All MRIs were performed immediately (1 hour) and after embolization (1, 2, and 4 weeks). Apparent diffusion coefficients (ADCs) were calculated for the femoral head. The estimated pharmacokinetic parameters (Kep and Ve from two-compartment model) and semi-quantitative parameters including peak enhancement, time-to-peak (TTP), and contrast washout were evaluated.ResultsThe epiphyseal ADC values of the ischemic hip decreased immediately (1 hour) after embolization. However, they increased rapidly at 1 week after embolization and remained elevated until 4 weeks after embolization. Perfusion MRI of ischemic hips showed decreased epiphyseal perfusion with decreased Kep immediately after embolization. Signal intensity-time curves showed delayed TTP with limited contrast washout immediately post-embolization. At 1-2 weeks after embolization, spontaneous reperfusion was observed in ischemic epiphyses. The change of ADC (p = 0.043) and Kep (p = 0.043) were significantly different between immediate (1 hour) after embolization and 1 week post-embolization.ConclusionDiffusion MRI and pharmacokinetic model obtained from the DCE-MRI are useful in depicting early changes of perfusion and tissue damage using the model of femoral head ischemia in skeletally immature piglets.

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“…25,58 There are two main categories of dynamic contrastenhanced perfusion MR imaging: dynamic susceptibility contrast-weighted imaging using T2-or T2*-weighted imaging (DSC-MRI) and dynamic contrast-enhanced MRI using T1-weighted imaging (DCE-MRI). Advanced MRI techniques involving injection of GBCAs now exist that provide physiological information such as tissue perfusion and capillary permeability quantification.…”

Section: Advanced Techniques Using Contrast Mediamentioning

confidence: 99%