Advanced-Technology Radiation Therapy in the Management of Bone and Soft Tissue Sarcomas

DeLaney, Thomas F.; Trofimov, Alexei V.; Engelsman, Martijn; Suit, Herman D.

doi:10.1177/107327480501200104

Cited by 92 publications

(69 citation statements)

References 67 publications

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“…RT can be administered as primary therapy preoperatively or postoperatively in STS. Advances in RT technology such as brachytherapy, intensity modulated radiation therapy (IMRT), and intraoperative radiation therapy (IORT) have led to improvement of treatment outcomes in patients with STS (DeLaney, 2005).…”

Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Duman¹,

Günaldı²,

Erçolak³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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Background: Soft tissue sarcomas (STS) must be managed with a team involving pathologists, radiologists, surgeons, radiation therapists and medical oncologists. Treatment modalities and demographic charasteristics of Turkish STS were analysed in the current study. Material-Methods: Primary adult STS followed between 1999-2010 in Cukurova University Medical Faculty Department of Medical Oncology were analzied retrospectively Results: Of the total of 498 patients, 238 were male and 260 female. The most seen adult sarcomas were leomyosarcoma (23%). Localization of disease was upper extremity (8.8%), lower extremity (24.7%), head-neck 8.2%, thoracic 8%, retroperitoneal 5.6%, uterine 12.4%, abdominal 10%, pelvic region 3.6 and other regions 10%. Some 13.1% were early stage, 10.2% locally advanced, 8.2% metastatic and 12.2% recurrent disease. Patients were treated with neoadjuvant/adjuvant (12%) or palliative chemotherapy (7.2%) and 11.4% patients did not receive chemotherapy. Surgery was performed as radical or conservative. The most preferred regimen was MAID combination chemotherapy in the rate of 17.6%. The most common metastatic site was lung (18.1%). The overall survival was 45 months (95%CI 30-59), 36 months in men and 55 months in women, with no statistically significant difference (p=0.5). The survival rates were not different between the group of adjuvant and palliative chemotherapy (respectively 28 versus 18 months) (p=0.06), but radical surgery at 37 months was better than 22 months for conservative surgery (p=0.0001). No differences were evident for localization (p=0.152). Locally advanced group had higher overall survival rates (72 months) than other stages (p=0.0001). Conclusion: STS can be treated successfully with surgery, chemotherapy and radiotherapy. The survival rates of Turkish people were higher in locally advanced group; these results show the importance of multimodality treatment approach and radical surgery.

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Section: Discussionmentioning

confidence: 99%

Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Duman¹,

Günaldı²,

Erçolak³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…71 The morbidity associated with conformal radiotherapy is lower than that of the conventional technique (D). 75,76 There are reports of significant toxicity rates associated with the conventional technique, with need for hospital intervention or progress to bowel obstruction (B). 16 Institutional series in which patients received conformal radiotherapy showed low rates of treatment-related complications, such as bleeding, intestinal obstruction and nephropathy (B) 77,78 (D).…”

Section: -73mentioning

confidence: 99%

Treatment of abdominal tumors using radiotherapy

Weltman¹,

Marta²,

Baraldi³

et al. 2015

Rev. Assoc. Med. Bras.

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“…The primary tumor types should be determined, the patient condition and the functional expectation should be evaluated, surgery with lower tendency invasiveness (such as vertebral plasty) or non-surgical therapy should be adopted for patients with shorter expected survival time or patients with more severe medical diseases, the risks and complications are discussed and evaluated with patients and family members together, and the possible functions after reconstructive surgery are informed to patients [6][7].…”

Section: Surgical Therapymentioning

confidence: 99%

Comprehensive treatment progress of metastatic bone tumor

Jiang¹,

Zhang²,

Wu³

et al. 2018

Proceedings of the 2018 International Workshop on Bioinformatics, Biochemistry, Biomedical Sciences (BBBS 2018)

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Abstract.Objective: to summarize and analyze the clinical characteristic and clinical features of metastatic bone tumors: metastatic bone tumors occur in male patients mostly, mainly including male patients from 41 to 70 years old. The most common primary lesions of male patients include lung, prostate and liver. The most common primary lesions of male patients include lung, breast, stomach and intestine and unknown origin. Early single lesion is mostly discovered in the spine and pelvis. Late lesion is mostly metastatic in many parts of the body. Patients are often diagnosed due to physical pain (swelling and dysfunction), pathological fracture and even paraplegia, etc.. Some patients are diagnosed due to symptoms of primary lesions, and bone metastasis is discovered during diagnosis examination. Osteolytic change is commonly discovered in imageology. Treatment is based on symptomatic treatment, pain relief, chemotherapy and radiotherapy. Surgery is mostly palliative. Conclusion: the clinical features of metastatic bone tumors are complicated, and the pathologic features of metastatic bone tumors should be grasped for early diagnosis and treatment.

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Advanced-Technology Radiation Therapy in the Management of Bone and Soft Tissue Sarcomas

Cited by 92 publications

References 67 publications

Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Retrospective Analysis of 498 Primary Soft Tissue Sarcomas in a Single Turkish Centre

Treatment of abdominal tumors using radiotherapy

Comprehensive treatment progress of metastatic bone tumor

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