Advanced Test of Attention in Children with Attention-Deficit/Hyperactivity Disorder in Japan for Evaluation of Methylphenidate and Atomoxetine Effects

Fujioka, Toru; Takiguchi, Shinichiro; Yatsuga, Chiho; Hiratani, Michio; Hong, Kang; Shin, Min Sup; Cho, Sungzoon; Kosaka, Hirotaka; Tomoda, Akemi

doi:10.9758/cpn.2016.14.1.79

Cited by 10 publications

(10 citation statements)

References 40 publications

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“…The percentage of patients showing improvement in inattention, hyperactivity, and impulsivity scores was 48.6%, 45.9%, and 45.9%, respectively. Moreover, Fujioka et al [42] reported a significant improvement in ADHD scores during the follow-up period with methylphenidate or Atomoxetine medication for inattentive symptom score, hyperactivity/impulsivity symptom.…”

Section: Discussionmentioning

confidence: 99%

Association between circulating zinc/ferritin levels and parent Conner’s scores in children with attention deficit hyperactivity disorder

et al. 2019

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ADHD is one of the most common neurobehavioral disorders among children and adolescents. In this prospective study, we aimed to measure circulating zinc and ferritin levels in children with ADHD, pick up the deficient ones to give zinc and iron supplements then compare before and after treatment according to their Conner’s scores and Wecsler IQ test. Current study included fifty children diagnosed as having ADHD by DSMV criteria, their zinc and ferritin levels were measured by Colorimetric method and enzyme-linked immunosorbent assay (ELISA) respectively. They were divided into: group I (zinc only deficient),group II (zinc and ferritin deficient),group III (non-deficient), cases with mineral deficiency received zinc (55 mg/day) and/or iron (6 mg/kg/day) for 6 months then reassessed by parent Conner’s rating scale. In group 1, there was no significant difference between the Wecsler verbal and non-verbal IQ scores and oppositional and cognitive problems in Conner’s scores before and after zinc supplements, although there was significant improvement in attention, hyperactivity, emotional liability and impulsivity. In group II, there was significant improvement in verbal and total IQ but not in performance IQ, also there was significant improvement in hyperactivity, emotional liability and impulsivity with no significant difference in oppositional, cognitive problems and inattention before and after zinc/ iron supplements. In Conclusion, Zinc supplements in adjuvant to the main treatment significantly improved symptoms of ADHD children. However, a combined zinc and iron supplements was superior to zinc alone in alleviating ADHD symptoms as well as IQ improvement.

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Section: Discussionmentioning

confidence: 99%

Association between circulating zinc/ferritin levels and parent Conner’s scores in children with attention deficit hyperactivity disorder

et al. 2019

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“…Among different versions of this test, we used the Advanced Test of Attention (ATA) that integrates both visual and auditory sensorial modalities, measuring attention, and response inhibition in Korean children older than 5 years (51). The target rate of stimulus presentation is 22% for the first section, 50% for the middle section, and 78% for the last section, with the stimulus presentation time of 0.1 s and an interval of 2 s between the presentations (39,52). This test includes both auditory and visual scores of omission errors (i.e., missed targets), commission errors (i.e., incorrect responses to non-targets), the mean of response time (i.e., response speed), response time variability, response criterion, and detectability (i.e., ability to distinguish targets from non-targets) (39).…”

Section: Advanced Test Of Attentionmentioning

confidence: 99%

Gray Matter Volume in the Developing Frontal Lobe and Its Relationship With Executive Function in Late Childhood and Adolescence: A Community-Based Study

et al. 2021

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Background: During late childhood and adolescence, the frontal lobe undergoes critical developmental changes, affecting a wide range of executive functions significantly. Conversely, abnormality in the maturation of the frontal lobe during this period may result in a limited ability to effectively use various executive functions. However, at present, it is still unclear how the structural development of the frontal lobe is associated with different aspects of executive functions during this developmental period. To fill the gap in evidence, we aimed to elucidate gray matter volume (GMV) in the frontal lobe and its relationship with multiple aspects of executive functions in late childhood and adolescence.Methods: We recruited our participants aged between 6 and 17 years to assess GMV in the frontal lobe and its relationship with different domains of executive functions in late childhood and adolescence. We used the voxel-based morphometry–DARTEL procedure to measure GMVs in multiple frontal sub-regions and Stroop test and Advanced Test of Attention (ATA) to measure executive functions. We then conducted partial correlation analyses and performed multiple comparisons with different age and sex groups.Results: Overall, 123 participants took part in our study. We found that many regional GMVs in the frontal lobe were negatively correlated with ATA scores in participants in late childhood and positively correlated with ATA scores in participants in adolescence. Only a few correlations of the GMVs with Stroop test scores were significant in both age groups. Although most of our results did not survive false discovery rate (FDR) correction (i.e., FDR <0.2), considering their novelty, we discussed our results based on uncorrected p-values. Our findings indicate that the frontal sub-regions that were involved in attentional networks may significantly improve during late childhood and become stabilized later in adolescence. Moreover, our findings with the Stroop test may also present the possibility of the later maturation of higher-order executive functioning skills.Conclusion: Although our findings were based on uncorrected p-values, the novelty of our findings may provide better insights into elucidating the maturation of the frontal lobe and its relationship with the development of attention networks in late childhood and adolescence.

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“…ATA [34] is widely used in Korea for the diagnosis of ADHD [35]; its usefulness has been verified in Japan [36]. ATA measures visual and auditory attention using a computer and can be executed by children and adolescents aged 5 to 15 years.…”

Section: Advanced Test Of Attention (Ata) and Interactive Metronome (Im)mentioning

confidence: 99%

Eye-Contact Game Using Mixed Reality for the Treatment of Children With Attention Deficit Hyperactivity Disorder

et al. 2020

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Many children with attention deficit hyperactivity disorder (ADHD) perform poorly in their academic studies. They also have difficulties in their social lives due to a lack of interpersonal skills and this often continues into adult life. Appropriate early therapies and medications can be very beneficial. In this paper, we introduce and demonstrate the benefits of a new type of treatment, namely, an eye-contact game which successfully exploits mixed reality technology. None of the patients in our experiment were older than ten years of age. They were able to pay attention and sustain interest in the treatment sessions over a span of six weeks. After participating in the treatment sessions with our game, the omission/commission errors which were evaluated in an attention test taken by the experimental group decreased significantly and appeared within the normal range. In addition to the improvement in error rates, the mean response time to an interactive metronome test significantly decreased. Importantly, our game allows patients to conduct this treatment by themselves at home without professional assistance. To the best of our knowledge, this study is one of the first studies to use a mixed reality head-mounted display to treat children with attention deficit hyperactivity disorder and to prove its potential as a treatment for clinically diagnosed children.

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Advanced Test of Attention in Children with Attention-Deficit/Hyperactivity Disorder in Japan for Evaluation of Methylphenidate and Atomoxetine Effects

Cited by 10 publications

References 40 publications

Association between circulating zinc/ferritin levels and parent Conner’s scores in children with attention deficit hyperactivity disorder

Association between circulating zinc/ferritin levels and parent Conner’s scores in children with attention deficit hyperactivity disorder

Gray Matter Volume in the Developing Frontal Lobe and Its Relationship With Executive Function in Late Childhood and Adolescence: A Community-Based Study

Eye-Contact Game Using Mixed Reality for the Treatment of Children With Attention Deficit Hyperactivity Disorder

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