Advanced time‐series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson's disease patients

Boesveldt, Sanne; Stam, Cornelis J.; Knol, Dirk L.; Verbunt, J.P.A.; Berendse, Henk W.

doi:10.1002/hbm.20726

Cited by 13 publications

(16 citation statements)

References 59 publications

(65 reference statements)

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“…We subdivided the included articles into two main groups according to the brain network the analysis was focused on: motor network-focused, in which we treated the tremor network as a sub-category, and whole-brain network focused. Since a series of articles on the neurophysiological basis of neuronal entrainment in PD (Te Woerd, Oostenveld, Bloem, De Lange, & Praamstra, 2015;Te Woerd, Oostenveld, De Lange, & Praamstra, 2014;Te Woerd, Oostenveld, De Lange, & Praamstra, 2017;Te Woerd, Oostenveld, de Lange, & Praamstra, 2018), as well as four other articles (Anninos, Adamopoulos, Kotini, & Tsagas, 2016;Boesveldt, Stam, Knol, Verbunt, & Berendse, 2009;Gomez et al, 2011;Suntrup et al, 2013) tended to stand alone from the rest of this review, these will not be discussed in the results section, but the main findings are provided in Table 1. 3 | RESULTS Neurophysiological measures relevant for this review; explanation of the measures can be found in Table 3.…”

Section: Methodsmentioning

confidence: 99%

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Boon

Geraedts

Hillebrand

et al. 2019

Human Brain Mapping

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Parkinson's disease (PD) is accompanied by functional changes throughout the brain, including changes in the electromagnetic activity recorded with magnetoencephalography (MEG). An integrated overview of these changes, its relationship with clinical symptoms, and the influence of treatment is currently missing. Therefore, we systematically reviewed the MEG studies that have examined oscillatory activity and functional connectivity in the PD‐affected brain. The available articles could be separated into motor network‐focused and whole‐brain focused studies. Motor network studies revealed PD‐related changes in beta band (13–30 Hz) neurophysiological activity within and between several of its components, although it remains elusive to what extent these changes underlie clinical motor symptoms. In whole‐brain studies PD‐related oscillatory slowing and decrease in functional connectivity correlated with cognitive decline and less strongly with other markers of disease progression. Both approaches offer a different perspective on PD‐specific disease mechanisms and could therefore complement each other. Combining the merits of both approaches will improve the setup and interpretation of future studies, which is essential for a better understanding of the disease process itself and the pathophysiological mechanisms underlying specific PD symptoms, as well as for the potential to use MEG in clinical care.

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Section: Methodsmentioning

confidence: 99%

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Boon

Geraedts

Hillebrand

et al. 2019

Human Brain Mapping

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“…Experimentally, several functional imaging studies, using positron emission tomography (PET) (Dade et al 1998;Zald and Pardo 2000;Savic and Gulyas 2000;Hummel et al 2009), functional magnetic resonance imaging (fMRI) (Levy et al 1999;Weismann et al 2001;Wang et al 2005), magnetoencephalography (MEG) (Tonoike et al 1998;Walla et al 2002;Miyanari et al 2006;Boesveldt et al 2009) and electroencephalography (EEG) (Tateyama et al 1998;Laudien et al 2006Laudien et al , 2008, had been performed to detect objective olfactory brain responses. In these studies, the orbitofrontal cortex, entorhinal cortex, hippocampus, insular cortex, hypothalamus, piriform cortex, amygdala, and anterior cingulate cortex were reported to be activated by olfactory stimulation.…”

Section: Introductionmentioning

confidence: 99%

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

et al. 2011

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Intravenous injection of thiamine propyldisulphide (TPD), which induces sensation of a garlic-like odor, has been used as a representative subjective olfactory test in Japan. However, cortical loci activated by TPD still remain unclear. We recorded cerebral hemodynamic responses (changes in Oxy-Hb concentrations) induced by TPD administration using whole-head multi-channel near infrared spectroscopy (NIRS) system based on 3D-MRIs. TPD as an odorant and saline as a control were injected from the cephalic vein in the left forearm in ten male normosmic (five young and five elderly) subjects and five dysosmic elderly patients. The all normosmic, but not dysosmic, subjects felt the garlic-like odor in the all TPD trials. There was no significant difference in hemodynamic responses between the young and elderly normosmic subjects. However, TPD injection induced significantly larger hemodynamic responses in the bilateral operculums, bilateral dorsolateral prefrontal cortices (PFC) and anteromedial PFC in the normosmic subjects, compared with saline injection. Onset latencies of these hemodynamic responses were significantly correlated with onset latencies of subjective odor sensation in the normosmic subjects. Comparison of hemodynamic responses between the normosmic and dysosmic subjects indicated a significant difference in the bilateral operculums. The results demonstrated that Oxy-Hb increases in the bilateral operculums reflected olfactory sensation induced by TPD injection. Consideration of a route for intravenous TPD to reach the olfactory mucosa suggests that these hemodynamic responses might be attributed to food-related retronasal olfactory responses to TPD.

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“…MEG is another complex neuroimaging technique used in olfactory paradigms [3,[70][71][72][73], and offers high temporal and spatial resolution and high data reliability [74,75]. In several studies, MEG has been used to describe the chronological sequence of different stages of processing in different neural substrates in olfactory paradigms [76].…”

Section: Magneto-encephalography and Chemical Perceptionmentioning

confidence: 99%

Chemosensory Perception: A Review on Electrophysiological Methods in “Cognitive Neuro-Olfactometry”

Invitto

Grasso

2019

Chemosensors

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Various brain imaging techniques are available, but few are specifically designed to visualize chemical sensory and, in particular, olfactory processing. This review describes the results of quantitative and qualitative studies that have used electroencephalography (EEG) and magneto-encephalography (MEG) to evaluate responses to olfactory stimulation (OS). EEG and MEG are able to detect the components of chemosensory event-related potentials (CSERPs) and the cortical rhythms associated with different types of OS. Olfactory studies are filling the gaps in both the developmental field of the life cycle (from newborns to geriatric age) and the clinical and basic research fields, in a way that can be considered the modern “cognitive neuro-olfactometry”.

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Advanced time‐series analysis of MEG data as a method to explore olfactory function in healthy controls and Parkinson's disease patients

Cited by 13 publications

References 59 publications

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

A systematic review of MEG‐based studies in Parkinson's disease: The motor system and beyond

Cortical Hemodynamic Responses to Intravenous Thiamine Propyldisulphide Administration Detected by Multichannel Near Infrared Spectroscopy (NIRS) System

Chemosensory Perception: A Review on Electrophysiological Methods in “Cognitive Neuro-Olfactometry”

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