A B S T R A C TAn ultrafiltration (UF) membrane process integrating ozone oxidation prior to a coagulation, flocculation, and sedimentation (CFS) pretreatment configuration processing surface water has been evaluated at the pilot-scale. Unlike prior research limited to short-term bench-scale evaluations, this current study provides information regarding the application of ozone oxidation prior to a CFS-UF pilot process operating over a four-month period (2,800 pilot runtime hours). In this work, changes in the long-term fouling behavior of the UF membrane process in response to the application of ozone prior to CFS pretreatment were characterized using fouling indices. When an average of 2.5 mg L −1 of ozone was applied prior to coagulation requiring 27 mg L −1 of polyaluminum chloride and a UF operating water flux of 85 L h −1 m −2 , the chemically reversible and hydraulically irreversible fouling indices increased by 59 and 40%, respectively. A reduction of chemically irreversible fouling concomitant with a continuous improvement of normalized specific flux was observed over 1,240 pilot runtime hours of ozone application. The total fouling index decreased by 41% as compared to the baseline CFS-UF configuration. This research indicates that the use of ozone oxidation prior to a CFS-UF configuration can reduce membrane fouling when integrated with conventional surface water treatment.