Advanced wound care materials: developing an alginate fibre containing branan ferulate

Abstract

A 1% w/v concentration of calcium chloride provides the optimum conditions for achieving suitably strong fibres with adequate absorption capacity, while allowing the least branan ferulate loss during wash and post-production treatments. In a laboratory setting the product showed promise. Research is now needed in a clinical setting and for comparison with existing wound-care products.

Advanced Wound-care Materials: Ultra High Absorbing Fibres made from Alginates Containing Branan Ferulate and Carboxymethyl Cellulose

“…It was earlier established (Miraftab et al, 2002) that a 5% w/v sodium alginate solution produced reasonably strong calcium alginate fibres. The addition of branan ferulate and NaCMC was regulated such that the overall solid content did not exceed the 5% w/v solids contents.…”

“…The machine set-up and full operational conditions have been described elsewhere (Miraftab et al, 2002). It is essentially an upright wet-extruder with three baths stationed on top of one another, such that the fibres/filaments are coagulated in the first bath and guided to the next bath directly above where drawing also takes place.…”

“…Branan ferulate (Kennedy et al, 1999), a corn extract, has been successfully co-spun with sodium alginate in different proportions. Studies by Miraftab et al, (2000Miraftab et al, ( , 2002Miraftab et al, ( , 2003 have shown that 25% w/w branan ferulate content provides an optimum outcome in terms of water and saline absorbency as well as tensile strength of the product fibres. However, to achieve even higher absorbencies, as required by some heavily exuding wounds, sodium carboxymethyl cellulose (NaCMC) has also been included in the spinning dope, without compromising too much of the tensile strength.…”

Wound care in Sri Lanka: our patients deserve better care

“…Some of these have led to the development of a more advanced dressing material and genetically engineered biological material. Advanced hydrocolloid dressings, exudate absorbing dressings, calcium alginate dressings, bacteria trapping hydrofibre dressings, cadexomer iodine dressings, nanocrystalline silver dressings, collagenase ointment (enzymatic debriding agent), and growth factors enhancing wound healing are some examples [2,3,6,8,[12][13][14][15][16][17]. Cultured epidermal grafts and artificial skin substitutes which provide a scaffold for the epithelial cells to grow, are other advances [18].…”

Bioactivation of PET woven fabrics using alginate biopolymer and the bacteriocin nisin

“…Moreover alginate in the form of fibers is used for wound dressing. 5 Alginate is a natural polysaccharide containing various proportions of mannuronate and guluronate monomers which are linked by glycosidic bonds (Figure 1(a)). Guluronate monomers in one alginate molecule can be linked to a similar region in another alginate molecule by means of calcium ions to form a gel.…”