Advancement and Validation of new Derivatives Spectrophotometric Method for Individual and Simultaneous Estimation of Diclofenac Sodium and Nicotinamide

Darweesh, Samar A.; Khalaf, Husam S.; Al-Khalisy, Rokayia Samir; Yaseen, Hamsa Muneam; Mahmood, Ruaa Muayed

doi:10.13005/ojc/340357

Cited by 7 publications

(5 citation statements)

References 7 publications

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“…Table 2 shows the comparison techniques used for the determination of PA, DF, and TR. It should be clearly emphasized that the proposed voltammetric procedure using the aSPCE/SDS mostly allows a significantly lower LOD to be obtained than those obtained for other techniques [7][8][9][10][11][12]14,[16][17][18]47]. In the case of the article [9], the calculated LOD of TR is lower (5.33 × 10 −10 vs. 1.71 × 10 −9 mol L −1 ), but the first concertation of TR from the calibration graph is higher than the one obtained at the aSPCE/SDS (1.67 × 10 −8 vs. 1.0 × 10 −8 mol L −1 ).…”

Section: Analytical Characteristicmentioning

confidence: 96%

“…Due to the possible side effects for humans as well as the negative impact on the environment, it is extremely important to develop sensitive and accurate methods for the determination of the presented drugs in samples of biological fluids and environmental samples. There are many analytical methods such as high-performance liquid chromatography (HPLC) [7][8][9], liquid chromatography-tandem mass spectrometry (LC-MS/MS) [10][11][12], gas chromatography-mass spectrometry (GC-MS) [13][14][15], and spectrophotometry [16][17][18], which are used to determine paracetamol, diclofenac, and tramadol. However, these methods are generally costly, requiring a time-consuming sample preparation step.…”

Section: Introductionmentioning

confidence: 99%

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Electrochemically Activated Screen-Printed Carbon Sensor Modified with Anionic Surfactant (aSPCE/SDS) for Simultaneous Determination of Paracetamol, Diclofenac and Tramadol

et al. 2021

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In this work, an electrochemically activated screen-printed carbon electrode modified with sodium dodecyl sulfate (aSPCE/SDS) was proposed for the simultaneous determination of paracetamol (PA), diclofenac (DF), and tramadol (TR). Changes of surface morphology and electrochemical behaviour of the electrode after the electrochemical activation with H2O2 and SDS surface modification were studied by scanning electron microscopy (SEM), cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). The influence of various parameters on the responses of the aSPCE/SDS such as pH and concentration of the buffer, SDS concentration, and techniques parameters were investigated. Using optimised conditions (Eacc. of −0.4 V, tacc. of 120 s, ΔEA of 150 mV, ν of 250 mV s−1, and tm of 10 ms), the aSPCE/SDS showed a good linear response in the concentration ranges of 5.0 × 10−8–2.0 × 10−5 for PA, 1.0 × 10−9–2.0 × 10−7 for DF, and 1.0 × 10−8–2.0 × 10−7 and 2.0 × 10−7–2.0 × 10−6 mol L−1 for TR. The limits of detection obtained during the simultaneous determination of PA, DF, and TR are 1.49 × 10−8 mol L−1, 2.10 × 10−10 mol L−1, and 1.71 × 10−9 mol L−1, respectively. The selectivity of the aSPCE/SDS was evaluated by examination of the impact of some inorganic and organic substances that are commonly present in environmental and biological samples on the responses of PA, DF, and TR. Finally, the differential pulse adsorptive stripping voltammetric (DPAdSV) procedure using the aSPCE/SDS was successfully applied for the determination of PA, DF, and TR in river water and serum samples as well as pharmaceuticals.

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Section: Analytical Characteristicmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Electrochemically Activated Screen-Printed Carbon Sensor Modified with Anionic Surfactant (aSPCE/SDS) for Simultaneous Determination of Paracetamol, Diclofenac and Tramadol

et al. 2021

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“…Tus, after being approximately converted depending on their molecular weights, mass ratios of 1 : 3, 1 : 2, 1 : 1, 1 : 0.5, 1 : 0.33, and 1 : 0.17, respectively, were used. Tere are many UV spectrophotometric techniques, including a pharmacopeial method for NCT [21][22][23] in addition to other methods such as high-performance liquid chromatography (HPLC), including a pharmacopeial method for IND [24][25][26] and electrochemical techniques [27,28] while the whole NCT range of absorption interfered with the signal of IND [9,29]. Our proposed analysis methods are the frst ones to simultaneously determine both IND and NCT.…”

Section: Introductionmentioning

confidence: 99%

Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques

Sarkis,

Sawan

2024

International Journal of Analytical Chemistry

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This research aims to develop methods for simultaneously determining indomethacin (IND) and nicotinamide (NCT) in binary mixtures, immediate-release capsules, sustained-release capsules, and co-amorphous systems, which were designed in 2021 to improve the solubility, dissolution rate, and stability of the amorphous state of indomethacin. Moreover, this new combination may have also other possible medical benefits. Therefore, there is a need to have simple, sensitive, and precise developed methods for simultaneous quantification analysis of IND/NCT in several different ratios. Three UV-spectrophotometry techniques were deployed: zero-crossing point in the second-order derivative, dual-wavelength in the first-order derivative, and ratio subtraction coupled with spectrum subtraction. The limit of detection and the limit of quantifications (LOD and LOQ) for IND were 0.41 and 1.25, 0.55 and 1.66, and 0.53 and 1.62 μg/mL, respectively, while for NCT were 0.53 and 1.59, 0.38 and 1.14, and 0.36 and 1.08 μg/mL, respectively. All methods were linear at least in the range of 2.5–40.0 μg/mL. All proposed methods were validated according to ICH guidelines and their application on the dosage formulations was carried out. Finally, the proposed methods were compared to a reference method for each IND and NCT, and no significant statistical variance was found.

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“…NCT does not absorb visual light. Instead, it has a sharp absorbance peak in the UV domain at 262 nm [ 12 , 27 ]. TRT absorbs visual light with wavelengths less than 440 nm.…”

Section: Introductionmentioning

confidence: 99%

Development and validation of derivative UV spectroscopic method for simultaneous estimation of nicotinamide and tretinoin in their binary mixtures and pharmaceutical preparations

Sarkis

Sawan

2022

BMC Chemistry

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An accurate, precise, sensitive, and simple spectroscopic method was developed and validated for simultaneous quantification analysis of tretinoin (TRT) and nicotinamide (NCT) with a ratio of 1:40 (TRT: NCT) in a synthetic mixture from dermal pharmaceutical preparations (solution and cream). Wavelengths were chosen in the first and second-order derivatives which are valid for the determination of NCT with the existence of TRT and excipients of the tested pharmaceutical preparations. Wavelength 253 nm was picked for the first-order derivative. Wavelengths 245 and 269 nm were picked for the second derivative. All previous wavelengths were zero-crossing points for TRT and its pharmaceutical preparations. Zero-order spectroscopy was used to determine TRT at the wavelength 348 nm, where no interference with NCT or any substance in the previous pharmaceutical preparation. The linearity range was studied and found to be 20–120 μg/mL and 0.5–5.0 μg/mL for NCT and TRT respectively. The correlation coefficient was 0.9995–0.9999 for NCT and 0.9998–0.9999 for TRT. The limit of detection (LOD) and the limit of quantification (LOQ) of NCT were 1.510 μg/mL and 4.590 μg/mL respectively at the wavelength 269 nm of the second-order derivative.

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Advancement and Validation of new Derivatives Spectrophotometric Method for Individual and Simultaneous Estimation of Diclofenac Sodium and Nicotinamide

Cited by 7 publications

References 7 publications

Electrochemically Activated Screen-Printed Carbon Sensor Modified with Anionic Surfactant (aSPCE/SDS) for Simultaneous Determination of Paracetamol, Diclofenac and Tramadol

Electrochemically Activated Screen-Printed Carbon Sensor Modified with Anionic Surfactant (aSPCE/SDS) for Simultaneous Determination of Paracetamol, Diclofenac and Tramadol

Method Development for Simultaneously Determining Indomethacin and Nicotinamide in New Combination in Oral Dosage Formulations and Co-Amorphous Systems Using Three UV Spectrophotometric Techniques

Development and validation of derivative UV spectroscopic method for simultaneous estimation of nicotinamide and tretinoin in their binary mixtures and pharmaceutical preparations

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