Advancement Flap Technique for Anal Fistula in Patients With Crohn's Disease: A Systematic Review of the Literature

Rozalén, V. Carrasco; Parés, David; Sanchez, Edward; Troya, José M.; Vela, Sandra; Pacha, Miguel Ángel; Piñol, Marta; Julián, Joan Francesc

doi:10.1016/j.cireng.2017.09.008

Cited by 14 publications

(8 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diese ist aber nur dann sinnvoll, wenn eine Remission im Rektum vorliegt [530,536]. Hier gilt der plastische Fistelverschluss im Sinne eines Verschiebelappens (nur Mukosa oder mit zusätzlich Muskel) als geeignete Methode, wobei die Erfolgsrate in neueren Übersichtsarbeiten bei knapp über 60 % angegeben wird [549,550]. Ähnlich gute Ergebnisse werden mit der LIFT (Ligation of the intersphincteric fistula tract)-Methode erreicht.…”

Section: Kommentarunclassified

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004

Sturm

Atreya

Bettenworth³

et al. 2022

Z Gastroenterol

View full text Add to dashboard Cite

Kinder und Jugendliche Fertilität Medikamente in der Schwangerschaft und Stillzeit Entbindung Impfungen des Neugeborenen Der*die ältere CED-Patient*in M. Crohn -Leitlinie AG 07 Ernährung Ernährung Ernährung als Krankheitsauslöser beim M. Crohn Ernährung als ein den Krankheitsverlauf modulierender Faktor Ernährung als therapeutischer Ansatz bei Patient*innen mit M. Crohn Ernährung zur Behandlung von Defiziten bzw. Mangelzuständen

show abstract

Section: Kommentarunclassified

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004

Sturm

Atreya

Bettenworth³

et al. 2022

Z Gastroenterol

View full text Add to dashboard Cite

show abstract

“…The standard surgical interventions for managing Crohn's perianal fistula include abscess drainage and seton replacement as the primary approaches to the acute phase of perianal sepsis [2]. Similar to other surgical methods, fistulotomy and novel strategies, including flaps, ligation of intersphincteric fistula tract (LIFT), video-assisted fistula therapy (VAAFT), and fistula tract laser treatment (FiLaC®), are considered the alternative approaches for the management of Crohn's fistula [3][4][5][6][7][8]. In addition to surgical intervention, medical management for perianal fistula is common to control sepsis and improve mucosal healing.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I

Nazari

Heirani

Asbagh

et al. 2022

Preprint

View full text Add to dashboard Cite

Background and objectives: Exosomes therapy is a promising technique that can decrease the concern related to the fate of transplanted stem cells to the fistula location. The unique properties of mesenchymal stem cells (MSCs)-derived exosomes can improve fistula healing because of their high ability to regulate and modify immune responses. This project aims to examine the safety and efficacy of implementing MSCs-exosomes in treating refractory fistulas in inflammatory bowel disease (IBD) patients. Methods: The exosomes were isolated from umbilical cord-derived MSCs and characterized using flow cytometry, western blotting, and transmittance electron microscope (TEM). Five patients (three men and two women) with refractory perianal Crohn’s disease with an average age of 35.4 years old were included. The patients did not match the exclusion criteria, and the presence of refractory fistulas was the main inclusion criteria. These patients have their exosomes injections in the operation room. The therapy responses of patients were assessed using physical examination, face-to-face interviews, computerized tomography (CT) scan, and magnetic resonance imaging (MRI) six months later. Result: The Following injection, patients reported a 70% improvement on average. Two patients claimed complete healing after exosome injections, while one patient reported no improvement and active discharge from the fistula site. In addition, five patients reported no adverse effects, both systemic or on the injection site. Conclusion: Injection of exosomes extracted from MSCs shows total safety and a satisfactory therapeutic impact, as shown in this and other research, and could play a significant role in the treatment of gastrointestinal fistulas in the future.

show abstract

“…2 In recent years, the introduction of glues and plugs in addition to surgical methods including flaps, ligation of intersphincteric fistula tract (LIFT), video-assisted fistula therapy (VAFT), and fistula tract laser treatment (FILAC) have gained popularity. [7][8][9][10][11] Long-term draining setons are used in some patients for abscess prevention. Medical management of perianal fistulas in Crohn's disease usually starts with antibiotics for controlling sepsis.…”

Section: Introductionmentioning

confidence: 99%

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

Nazari

Naei

Heirani‐Tabasi

et al. 2021

Inflammatory Bowel Diseases

View full text Add to dashboard Cite

Regenerative medicine is an emerging therapeutic method that aims to reconstruct tissues and organs. This advanced therapeutic approach has demonstrated great potential in addressing the limitations of medical and surgical procedures for treating perineal fistula in patients with Crohn’s disease. Recent developments in stem cell technology have led to a massive good manufacturing practices (GMPs) production of various stem cells, including mesenchymal and embryonic cells, along with induction of pluripotent stem cells to repair damaged tissues in the fistula. The recent advances in separation and purification of exosomes, as biologic nanovesicles carrying anti-inflammatory and regenerative agents, have made them powerful tools to treat this inflammatory disease. Further, tremendous advances in nanotechnology, biomaterials, and scaffold fabrication methods enable tissue engineering methods to synthesize tissue-like structures to assist surgical techniques. This review focuses on advanced regenerative-based methods including stem cell therapy, exosome therapy, and tissue engineering used in the treatment of perianal fistula. Relevant in vitro and in vivo studies and the latest innovations in implementation of regenerative medicine for this disease are also separately reviewed. Additionally, current challenges regarding implementation of g stem cells, exosomes, and tissue engineering methods for bridging the gaps between laboratory findings and clinic application will be discussed.

show abstract

Advancement Flap Technique for Anal Fistula in Patients With Crohn's Disease: A Systematic Review of the Literature

Cited by 14 publications

References 29 publications

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004

Aktualisierte S3-Leitlinie „Diagnostik und Therapie des Morbus Crohn“ der Deutschen Gesellschaft für Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS) – August 2021 – AWMF-Registernummer: 021-004

Evaluating the Safety and Efficacy of MSCs-derived Exosomes for Treatment of Resistant Perianal Fistula in IBD patients; Clinical Trial Phase I

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

Contact Info

Product

Resources

About