Advancement in CRISPR/Cas9 Technology to Better Understand and Treat Neurological Disorders

Datta, Aishika; Sarmah, Deepaneeta; Kaur, Harpreet; Chaudhary, Antra; Vadak, Namrata; Borah, Anupom; Shah, Sudhir V.; Wang, Xin; Bhattacharya, Pallab

doi:10.1007/s10571-022-01242-3

Cited by 5 publications

(2 citation statements)

References 107 publications

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“…The culmination of advancements in neuroscience, surgery, and technology have allowed for significant breakthroughs in neurosurgery (e.g., DBS, awake craniotomy, focused ultrasound, etc. ); [92][93][94] further, subspecialization and involvement of multidisciplinary teams have allowed for even more advancements in a variety of neurosurgery fields (e.g., neuro-oncology, neuro-IR, pediatric and functional neurosurgery) [95][96][97][98]. These advancements began from the ground up, often due to one individualthis highlights the continued importance of innovations in neurosurgery at all levels.…”

Section: How Innovation Could Be Advanced In Neurosurgerymentioning

confidence: 99%

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources

Lucke‐Wold¹

2022

NND

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Innovation is central to neurosurgery and has dramatically increased over the last twenty years. Although the specialty innovates as a whole, only 3-4.7% of practicing neurosurgeons hold patents. Various roadblocks to innovation impede this process such as lack of understanding, increasing regulatory complexity, and lack of funding. Newly emerging technologies allow us to understand how to innovate and how to learn from other medical specialties. By further understanding the process of innovation, and the funding that supports it, Neurosurgery can continue to hold innovation as one of its’s central tenets.

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Section: How Innovation Could Be Advanced In Neurosurgerymentioning

confidence: 99%

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources

Lucke‐Wold¹

2022

NND

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“…Rodent, rat, and monkey models have all been made with CRISPR-Cas9. [2][3][4][5] This shows how quickly it can be used to make animals with single-gene or multiple-gene changes. Additionally, the mutant strains with changed germlines are no longer needed with in vivo gene editing, which uses the CRISPR-Cas9 system to target cells of interest in their normal tissues.…”

Section: Introductionmentioning

confidence: 99%

CRISPR-Cas Associated Cells and Animal Mediated Biomedical Modelling

Nazir,

A. Mirza,

Rao

2024

Preprint

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Gene editing is now easy to make new disease models through in-vivo and in vitro tests. It can potentially be used to make animals with single-gene or multiple-gene changes. The mutant strains with changed germlines are no longer needed with in vivo gene editing, which uses the CRISPR-Cas9 system to target cells of interest in their normal tissues. Whereas, the AAVs and other viral vectors have made it possible to change cells selectively. Gene editing hade made it possible to use human induced pluripotent stem cells (iPSC) to model diseases that run in families. Researchers can compare and contrast the human genomes of many different ethnic and racial groups using this method. Scientists may be able to make a disease in a lab dish using iPSCs from a patient. Using CRISPR, iPSCs made from patient cells can be fixed if they have certain problems. This shows that gene therapy is possible and shows what happens when cells aren't working right. The fact that CRISPR-Cas9 can change the DNA by just one nucleotide has had a huge effect on biological studies. CRISPR is becoming more and more popular, which shows how useful, easy, and effective it is. With the broad use of CRISPR-based apps, the tool is now used for much more than just changing genes. This method can be used to screen the whole genome, control the translation of genes based on their sequence, and edit several genes at the same time. Scientists can now model diseases in different species and learn more about how genes work because of these advances. Genome-wide association studies and genome-editing tools like CRISPR are giving us a good look at the future of personalized medicine.

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Untangling a taxonomy of living from the science of the continuum of life

Buchman

2024

Current Opinion in Behavioral Sciences

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Advancement in CRISPR/Cas9 Technology to Better Understand and Treat Neurological Disorders

Cited by 5 publications

References 107 publications

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources

Innovation in Neurosurgery: Lessons Learned, Obstacles, and Potential Funding Sources

CRISPR-Cas Associated Cells and Animal Mediated Biomedical Modelling

Untangling a taxonomy of living from the science of the continuum of life

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