Advancement in the development of gene/protein-based vaccines against African swine fever virus

Wang, Ning; Huang, Pan; Zhang, Jun; Lin, Minqi; Lai, Xiaoru; Chen, Jianwen; Pan, Chungen

doi:10.1016/j.crmicr.2024.100232

Cited by 1 publication

(1 citation statement)

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“…It is worth noting that while co-immunization is a promising strategy, it remains unclear which ASFV proteins are effective immunogens due to the vast and complex ASFV genome. The identification of effective immunogens is crucial for coping with highly variable ASFV strains [ 97 , 98 ].…”

Section: Control Strategiesmentioning

confidence: 99%

Genetic Variations of African Swine Fever Virus: Major Challenges and Prospects

Chen,

Wang,

Luo

et al. 2024

Viruses

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African swine fever (ASF) is a contagious viral disease affecting pigs and wild boars. It typically presents as a hemorrhagic fever but can also manifest in various forms, ranging from acute to asymptomatic. ASF has spread extensively globally, significantly impacting the swine industry. The complex and highly variable character of the ASFV genome makes vaccine development and disease surveillance extremely difficult. The overall trend in ASFV evolution is towards decreased virulence and increased transmissibility. Factors such as gene mutation, viral recombination, and the strain-specificity of virulence-associated genes facilitate viral variations. This review deeply discusses the influence of these factors on viral immune evasion, pathogenicity, and the ensuing complexities encountered in vaccine development, disease detection, and surveillance. The ultimate goal of this review is to thoroughly explore the genetic evolution patterns and variation mechanisms of ASFV, providing a theoretical foundation for advancement in vaccine and diagnostic technologies.

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Section: Control Strategiesmentioning

confidence: 99%