Advancement of multifunctional hybrid nanogel systems: Construction and application in drug co-delivery and imaging technique

Ma, Yakun; Ge, Yanxiu; Li, Lingbing

doi:10.1016/j.msec.2016.11.031

Cited by 40 publications

(21 citation statements)

References 76 publications

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“…One advantage over micelles and liposomes is that moisture-sensitive payloads can be loaded from nonaqueous phases during the synthesis of polymeric nanoparticles, protecting them from degradation during DDS preparation and transport within the body. For further discussion of the principles, preparation, and biomedical applications of polymeric nanoparticles and nanogels, the reader is referred to several excellent reviews [ 150 , 151 , 152 , 153 ].…”

Section: Nanocarrier Platforms and Binding Strategiesmentioning

confidence: 99%

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Sun

Davis

2021

Nanomaterials

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To achieve the promise of stimuli-responsive drug delivery systems for the treatment of cancer, they should (1) avoid premature clearance; (2) accumulate in tumors and undergo endocytosis by cancer cells; and (3) exhibit appropriate stimuli-responsive release of the payload. It is challenging to address all of these requirements simultaneously. However, the numerous proof-of-concept studies addressing one or more of these requirements reported every year have dramatically expanded the toolbox available for the design of drug delivery systems. This review highlights recent advances in the targeting and stimuli-responsiveness of drug delivery systems. It begins with a discussion of nanocarrier types and an overview of the factors influencing nanocarrier biodistribution. On-demand release strategies and their application to each type of nanocarrier are reviewed, including both endogenous and exogenous stimuli. Recent developments in stimuli-responsive targeting strategies are also discussed. The remaining challenges and prospective solutions in the field are discussed throughout the review, which is intended to assist researchers in overcoming interdisciplinary knowledge barriers and increase the speed of development. This review presents a nanocarrier-based drug delivery systems toolbox that enables the application of techniques across platforms and inspires researchers with interdisciplinary information to boost the development of multifunctional therapeutic nanoplatforms for cancer therapy.

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Section: Nanocarrier Platforms and Binding Strategiesmentioning

confidence: 99%

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Sun

Davis

2021

Nanomaterials

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“…It was found that βCD and HPβCD increased solubility of ibuprofen to 7 mg/ml and 8 mg/ml, respectively. [28,29] In this work, preparation of hybrid nanogels based on cyclodextrin cross-linked with hydrophilic monomer, 2-acrylamido-2-methyl propane sulfonic acid (AMPS), is described. [20] The weaker interaction increases possibility of drug decomplexation and precipitation after administration due to dilution of the complexes in biological fluid.…”

Section: Introductionmentioning

confidence: 99%

“…The cyclodextrin hybrid nanogels are anticipated to facilitate characteristics of cyclodextrins itself. Additionally, they also possess good stabilities and rheological properties of polymers …”

Section: Introductionmentioning

confidence: 99%

“…Additionally, they also possess good stabilities and rheological properties of polymers. [28,29] In this work, preparation of hybrid nanogels based on cyclodextrin cross-linked with hydrophilic monomer, 2-acrylamido-2-methyl propane sulfonic acid (AMPS), is described. A simple free radical polymerization technique was employed to prepare nanogels followed by loading of dexibuprofen by lyophilization.…”

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confidence: 99%

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Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

2017

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The purpose of this study was to develop and characterize hydroxypropyl-βcyclodextrin (HPβCD) hybrid nanogels for solubility enhancement of lipophilic drug, dexibuprofen. HPβCD hybrid nanogels were designed by chemical crosslinking of hydroxypropyl-β-cyclodextrin with 2-acrylamido-2-methyl propane sulfonic acid (AMPS) via free radical polymerization. Loading efficiency, solubilization, zetasizer, FESEM Fourier transform infrared (FTIR), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD), and in vitro drug release analysis were performed for characterization of hybrid nanogels. Efficient solubilization of dexibuprofen has been observed by HPβCD hybrid nanogels. FTIR, TGA, and DSC studies confirmed the formation of new hybrid nanogels and complexation of dexibuprofen with nanogels. XRD analysis revealed loss of dexibuprofen crystallinity in hybrid nanogels. Highly porous and amorphous nanogels showed a significant dexibuprofen release in aqueous medium. In toxicity studies, no significant changes in behavioral, physiological, biochemical, or histopathological parameters of animals endorsed that developed formulations are nontoxic and biocompatible. K E Y W O R D Samorphous, differential scanning calorimetry, drug delivery systems, Fourier transform infrared, hostguest systems, hybrid nanogels, hydroxypropyl-β-cyclodextrin, nanotechnology, radical polymerization, thermal gravimetric analysis, toxicity studies

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“…Temperature, light, and magnetic-responsive nanogel composites have been explored for applications within drug delivery, as soft robots, sensors, and vehicles for capture and delivery [35]. Magnetic-responsive nanogel composites in particular are also popular in imaging and diagnostics, as reviewed in [36]. Systems composed of small dimension gels surrounding an NP core can also be used as an intermediate step in the formation of hydrogel shells with liquid cores, achieved by the dissolution of the NP core [37].…”

Section: Design Of Nanoparticle–hydrogel Compositesmentioning

confidence: 99%

Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior

2019

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Hydrogels are materials used in a variety of applications, ranging from tissue engineering to drug delivery. The incorporation of nanoparticles to yield composite hydrogels has gained substantial momentum over the years since these afford tailor-making and extend material mechanical properties far beyond those achievable through molecular design of the network component. Here, we review different procedures that have been used to integrate nanoparticles into hydrogels; the types of interactions acting between polymers and nanoparticles; and how these underpin the improved mechanical and optical properties of the gels, including the self-healing ability of these composite gels, as well as serving as the basis for future development. In a less explored approach, hydrogels have been used as dispersants of nanomaterials, allowing a larger exposure of the surface of the nanomaterial and thus a better performance in catalytic and sensor applications. Furthermore, the reporting capacity of integrated nanoparticles in hydrogels to assess hydrogel properties, such as equilibrium swelling and elasticity, is highlighted.

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Advancement of multifunctional hybrid nanogel systems: Construction and application in drug co-delivery and imaging technique

Cited by 40 publications

References 76 publications

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Nanoplatforms for Targeted Stimuli-Responsive Drug Delivery: A Review of Platform Materials and Stimuli-Responsive Release and Targeting Mechanisms

Hydroxypropyl‐β‐cyclodextrin hybrid nanogels as nano‐drug delivery carriers to enhance the solubility of dexibuprofen: Characterization, in vitro release, and acute oral toxicity studies

Nanoparticle-Hydrogel Composites: From Molecular Interactions to Macroscopic Behavior

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