Advancements in Canadian Biomaterials Research in Neurotraumatic Diagnosis and Therapies

Abstract

Development of biomaterials for the diagnosis and treatment of neurotraumatic ailments has been significantly advanced with our deepened knowledge of the pathophysiology of neurotrauma. Canadian research in the fields of biomaterial-based contrast agents, non-invasive axonal tracing, non-invasive scaffold imaging, scaffold patterning, 3D printed scaffolds, and drug delivery are conquering barriers to patient diagnosis and treatment for traumatic injuries to the nervous system. This review highlights some of the highly interdisciplinary Canadian research in biomaterials with a focus on neurotrauma applications.

Bio-piezoelectricity: fundamentals and applications in tissue engineering and regenerative medicine

“…Neurotrauma is a leading risk factor for mortality around the world and is a major public health problem (Rubiano et al 2015 ) (Reilly 2007 ). A variety of biomaterials have shown promise in enhancing and/or repairing the function of damaged nervous system tissue (Chen et al 2019 ). However, considerable obstacles remain in the way of full functional recovery of nervous system tissue, such as those concerned with delayed or partial tissue regeneration (Khaing et al 2014 ).…”

Endo and Exoskeleton: New Technologies on Composite Materials

“…Moreover, a different topic is all the biomaterials originating from living matter, such as bone substitutes. Thanks to new technologies, these materials, just like those under examination of the communication, could be milled or printed with CAD (Computer Aided Design) CAM (Computer Aided Manufacturing) systems [3][4][5][6][7]. In the technopolymers field, the composite flow molding (CFM) technology allows the production of composite materials strongly reinforced with long fiber without damaging the fibers.…”