Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy

Dhas, Namdev; García, Mónica Cristina; Kudarha, Ritu; Pandey, Abhijeet; Nikam, Ajinkya Nitin; Gopalan, Divya; Fernandes, Gasper; Soman, Soji; Kulkarni, Sanjay; Seetharam, Raviraja N.; Tiwari, Ruchi; Wairkar, Sarika; Pardeshi, Chandrakantsing V.; Mutalik, Srinivas

doi:10.1016/j.jconrel.2022.04.019

Cited by 64 publications

(31 citation statements)

References 266 publications

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“…For example, macrophage cell membrane‐cloaked systems were demonstrated for targeted delivery of drugs to inflammatory sites and tumorous tissues 119 ; cancer cell membrane‐coated particles could enhance cellular uptake, tumor‐specific targeting, and immune response 48–53 ; and bacterial cell membrane‐coated particles also exhibited tumor‐targeting and immune stimulation features in O 2 ‐dependent cancer treatment 54,55 . The fabrication process of the membrane‐coated particles mainly includes two steps (Figure 4): (i) cell membranes are first isolated via hypotonic treatment, ultrasonic cell disruption or repeated freezing and thawing; and (ii) the particle cores are then coated by membranes through mechanical coextrusion, sonication, microfluidic electroporation, or electrostatic attractions, and so on 110,113,118,120–122 …”

Section: Development Of Engineered Photoresponsive Biohybridsmentioning

confidence: 99%

“…The resultant membrane‐coated nanoparticle faithfully preserved the bilayer structures and functional surface proteins of the erythrocyte membranes, which enabled the biomimetic nanoparticle to exhibit the long circulation property from the source cells. Besides erythrocyte membranes, a variety of natural membrane‐coated particles have been developed with different functions for biomedical applications 24–26,113–118 . For example, macrophage cell membrane‐cloaked systems were demonstrated for targeted delivery of drugs to inflammatory sites and tumorous tissues 119 ; cancer cell membrane‐coated particles could enhance cellular uptake, tumor‐specific targeting, and immune response 48–53 ; and bacterial cell membrane‐coated particles also exhibited tumor‐targeting and immune stimulation features in O 2 ‐dependent cancer treatment 54,55 .…”

Section: Development Of Engineered Photoresponsive Biohybridsmentioning

confidence: 99%

“…Besides erythrocyte membranes, a variety of natural membrane-coated particles have been developed with different functions for biomedical applications. [24][25][26][113][114][115][116][117][118] For example, macrophage cell membrane-cloaked systems were demonstrated for targeted delivery of drugs to and NC@Ce6, showing that the NC particle size was reduced from 112 nm (pH 7.4) to a tumor penetration favorable size (34 nm) under weakly acidic conditions (pH 6.0). Reproduced with permission.…”

Section: Cell Membrane-based Photoresponsive Biohybridsmentioning

confidence: 99%

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Engineered photoresponsive biohybrids for tumor therapy

2023

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Engineered biohybrids have recently emerged as innovative biomimetic platforms for cancer therapeutic applications. Particularly, engineered photoresponsive biohybrids hold tremendous potential against tumors due to their intriguing biomimetic properties, photoresponsive ability, and enhanced biotherapeutic functions. In this review, the design principles of engineered photoresponsive biohybrids and their latest progresses for tumor therapy are summarized. Representative engineered photoresponsive biohybrids are highlighted including biomolecules-associated, cell membrane-based, eukaryotic cell-based, bacteria-based, and algae-based photoresponsive biohybrids. Representative tumor therapeutic modalities of the engineered photoresponsive biohybrids are presented, including photothermal therapy, photodynamic therapy, synergistic therapy, and tumor therapy combined with tissue regeneration. Moreover, the challenges and future perspectives of these photoresponsive biohybrids for clinical practice are discussed.

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Section: Development Of Engineered Photoresponsive Biohybridsmentioning

confidence: 99%

Section: Development Of Engineered Photoresponsive Biohybridsmentioning

confidence: 99%

Section: Cell Membrane-based Photoresponsive Biohybridsmentioning

confidence: 99%

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Engineered photoresponsive biohybrids for tumor therapy

2023

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“…Natural cell membranes are the most biocompatible vectors for surface functionalization of NPs. The coated NPs will acquire the inherent physicochemical properties of cell membranes [ 102 , 103 ].…”

Section: Modifications For Targetingmentioning

confidence: 99%

2D Hetero-Nanoconstructs of Black Phosphorus for Breast Cancer Theragnosis: Technological Advancements

et al. 2022

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As per global cancer statistics of 2020, female breast cancer is the most commonly diagnosed cancer and also the foremost cause of cancer death in women. Traditional treatments include a number of negative effects, making it necessary to investigate novel smart drug delivery methods and identify new therapeutic approaches. Efforts for developing novel strategies for breast cancer therapy are being devised worldwide by various research groups. Currently, two-dimensional black phosphorus nanosheets (BPNSs) have attracted considerable attention and are best suited for theranostic nanomedicine. Particularly, their characteristics, including drug loading efficacy, biocompatibility, optical, thermal, electrical, and phototherapeutic characteristics, support their growing demand as a potential substitute for graphene-based nanomaterials in biomedical applications. In this review, we have explained different platforms of BP nanomaterials for breast cancer management, their structures, functionalization approaches, and general methods of synthesis. Various characteristics of BP nanomaterials that make them suitable for cancer therapy and diagnosis, such as large surface area, nontoxicity, solubility, biodegradability, and excellent near-infrared (NIR) absorption capability, are discussed in the later sections. Next, we summarize targeting approaches using various strategies for effective therapy with BP nanoplatforms. Then, we describe applications of BP nanomaterials for breast cancer treatment, which include drug delivery, codelivery of drugs, photodynamic therapy, photothermal therapy, combined therapy, gene therapy, immunotherapy, and multidrug resistance reversal strategy. Finally, the present challenges and future aspects of BP nanomaterials are discussed.

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“…However, there are still many inadequacies that limit the application of nanoformulations in biomedicine, including limited tumor penetration and insufficient specificity. Furthermore, nanoformulations are often recognized as foreign materials by the reticuloendothelial system (RES) or the mononuclear phagocytosis system (MPS) [ 4 ]. The subsequent rapid clearance from blood circulation by the liver and kidneys results in insufficient drug accumulation in the target tissue [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Lin¹,

Peng²,

Yu³

et al. 2023

Beilstein J. Nanotechnol.

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Immune clearance and insufficient targeting have limited the efficacy of existing therapeutic strategies for cancer. Toxic side effects and individual differences in response to treatment have further limited the benefits of clinical treatment for patients. Biomimetic cancer cell membrane-based nanotechnology has provided a new approach for biomedicine to overcome these obstacles. Biomimetic nanoparticles exhibit various effects (e.g., homotypic targeting, prolonging drug circulation, regulating the immune system, and penetrating biological barriers) after encapsulation by cancer cell membranes. The sensitivity and specificity of diagnostic methods will also be improved by utilizing the properties of cancer cell membranes. In this review, different properties and functions of cancer cell membranes are presented. Utilizing these advantages, nanoparticles can exhibit unique therapeutic capabilities in various types of diseases, such as solid tumors, hematological malignancies, immune system diseases, and cardiovascular diseases. Furthermore, cancer cell membrane-encapsulated nanoparticles show improved effectiveness and efficiency in combination with current diagnostic and therapeutic methods, which will contribute to the development of individualized treatments. This strategy has promising clinical translation prospects, and the associated challenges are discussed.

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Advancements in cell membrane camouflaged nanoparticles: A bioinspired platform for cancer therapy

Cited by 64 publications

References 266 publications

Engineered photoresponsive biohybrids for tumor therapy

Engineered photoresponsive biohybrids for tumor therapy

2D Hetero-Nanoconstructs of Black Phosphorus for Breast Cancer Theragnosis: Technological Advancements

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

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