Advancements in chemical biology targeting the kinases and phosphatases of RNA polymerase II-mediated transcription

Kim, Wantae; LeBlanc, Blase M.; Matthews, Wendy L.; Zhang, Zhong-Yin; Zhang, Yan

doi:10.1016/j.cbpa.2021.02.002

Cited by 1 publication

(1 citation statement)

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“…As described above, Tat recruits the transcription factor P-TEFb, a multimeric complex that includes cyclin-dependent kinase 9 (CDK9):cyclin-T1. This Ser/Thr kinase phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) [ 29 , 30 ]. CDK9 activity is required in the early elongation phase to convert Pol II into a full elongation-competent polymerase (reviewed by Egloff [ 31 ]).…”

Section: Pp1 In Viral Infectionsmentioning

confidence: 99%

Emerging roles of the Protein Phosphatase 1 (PP1) in the context of viral infections

Corda,

Bollen,

Ribeiro

et al. 2024

Cell Commun Signal

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Protein Phosphatase 1 (PP1) is a major serine/threonine phosphatase in eukaryotes, participating in several cellular processes and metabolic pathways. Due to their low substrate specificity, PP1’s catalytic subunits do not exist as free entities but instead bind to Regulatory Interactors of Protein Phosphatase One (RIPPO), which regulate PP1’s substrate specificity and subcellular localization. Most RIPPOs bind to PP1 through combinations of short linear motifs (4–12 residues), forming highly specific PP1 holoenzymes. These PP1-binding motifs may, hence, represent attractive targets for the development of specific drugs that interfere with a subset of PP1 holoenzymes. Several viruses exploit the host cell protein (de)phosphorylation machinery to ensure efficient virus particle formation and propagation. While the role of many host cell kinases in viral life cycles has been extensively studied, the targeting of phosphatases by viral proteins has been studied in less detail. Here, we compile and review what is known concerning the role of PP1 in the context of viral infections and discuss how it may constitute a putative host-based target for the development of novel antiviral strategies.

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Section: Pp1 In Viral Infectionsmentioning

confidence: 99%