Advancements in clinical translation of flavonoid nanoparticles for cancer treatment

Sharma, Tripti; Singh, Deepika; Mahapatra, Aastha; Mohapatra, Priyanka; Sahoo, Shraban Kumar; Sahoo, Sanjeeb K.

doi:10.1016/j.onano.2022.100074

Cited by 20 publications

(22 citation statements)

References 175 publications

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“…Use of liposomal nanoparticles with quercetin have been reported in liver cancer and showed its effect by the downregulation of HSP70 and cell cycle arrest. Gold particles with a size of 106.7 nm with quercetin, have also been reported in liver cancer and the effects included release of cytochrome c through cleavage of caspase-3 and caspase-9, decrease in COX-2 via suppression of NF-κB nuclear translocation and its binding to the COX-2 promoter and the inactivation of Akt and ERK1/2 signaling pathways [ 84 ]. Table 1 summarizes delivery systems for quercetin developed against different cancers.…”

Section: Nano Delivery Of Quercetin In Liver Cancermentioning

confidence: 99%

Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

et al. 2023

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Due to rising incidence rates of liver cancer and worries about the toxicity of current chemotherapeutic medicines, the hunt for further alternative methods to treat this malignancy has escalated. Compared to chemotherapy, quercetin, a flavonoid, is relatively less harmful to normal cells and is regarded as an excellent free-radical scavenger. Apoptotic cell death of cancer cells caused by quercetin has been demonstrated by many prior studies. It is present in many fruits, vegetables, and herbs. Quercetin targets apoptosis, by upregulating Bax, caspase-3, and p21 while downregulating Akt, PLK-1, cyclin-B1, cyclin-A, CDC-2, CDK-2, and Bcl-2. Additionally, it has been reported to increase STAT3 protein degradation in liver cancer cells while decreasing STAT3 activation. Quercetin has a potential future in chemoprevention, based on substantial research on its anticancer effects. The current review discusses quercetin’s mechanisms of action, nanodelivery strategies, and other potential cellular effects in liver cancer.

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Section: Nano Delivery Of Quercetin In Liver Cancermentioning

confidence: 99%

Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

et al. 2023

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“…106,186 In this regard, several potential phytochemicals with multimodal anticancer properties are gaining much interest for use in anticancer therapy, either individually or in combination with chemotherapeutics. 30,25,44 However, translational success of phytochemicals remains low, and a number of phytochemicals have been withdrawn in different phases of clinical trials due to their inadequate drug profiles. 30,187 For example, when native curcumin was administered at a dose higher than 12 g in healthy volunteers, very low levels of curcumin were detected in the serum, resulting in poor bioavailability and thereby limiting its systemic cancer preventive activity.…”

Section: Future Outlook and Challenges For Phytonanomedicinesmentioning

confidence: 99%

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

Sa,

Mohapatra,

Swain

et al. 2023

Mol. Pharmaceutics

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Cancer remains the leading cause of death and rapidly evolving disease worldwide. The understanding of disease pathophysiology has improved through advanced research investigation, and several therapeutic strategies are being used for better cancer treatment. However, the increase in cancer relapse and metastatic-related deaths indicate that available therapies and clinically approved chemotherapy drugs are not sufficient to combat cancer. Further, the constant crosstalk between tumor cells and the tumor microenvironment (TME) is crucial for the development, progression, metastasis, and therapeutic response to tumors. In this regard, phytochemicals with multimodal targeting abilities can be used as an alternative to current cancer therapy by inhibiting cancer survival pathways or modulating TME. However, due to their poor pharmacokinetics and low bioavailability, the success of phytochemicals in clinical trials is limited. Therefore, developing phytochemical-based nanomedicine or phytonanomedicine can improve the pharmacokinetic profile of these phytochemicals. Herein, the molecular characteristics and pharmacological insights of the proposed phytonanomedicine in cancer therapy targeting tumor tissue and altering the characteristics of cancer stem cells, chemoresistance, TME, and cancer immunity are well discussed. Further, we have highlighted the clinical perspective and challenges of phytonanomedicine in filling the gap in potential cancer therapeutics using various nanoplatforms. Overall, we have discussed how clinical success and pharmacological insights could make it more beneficial to boost the concept of nanomedicine in the academic and pharmaceutical fields to counter cancer metastases and drug resistance.

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“…This approach may also prevent vascular endothelium damage, decrease toxicity, and reduce the frequency of drug administration. 208 In light of the potential provided by nano-encapsulation, a technology called PHYTOSOME ® has been patented and developed, which has demonstrated significant success in delivering bioactive compounds. This technology has been found to enhance the bioavailability of molecules, thereby improving their therapeutic efficacy.…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

“…The aforementioned studies serve as a promising foundation for the application of nano-encapsulated flavonoids in the preoperative management of cancer patients, particularly as a potential avenue for neoadjuvant chemotherapy in clinical settings. 208…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis

Proença

Freitas

Ribeiro

et al. 2023

Medicinal Research Reviews

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One of the hallmarks of cancer is metastasis, a process that entails the spread of cancer cells to distant regions in the body, culminating in tumor formation in secondary organs. Importantly, the proinflammatory environment surrounding cancer cells further contributes to cancer cell transformation and extracellular matrix destruction. During metastasis, front‐rear polarity and emergence of migratory and invasive features are manifestations of epithelial‐mesenchymal transition (EMT). A variety of transcription factors (TFs) are implicated in the execution of EMT, the most prominent belonging to the Snail Family Transcriptional Repressor (SNAI) and Zinc Finger E‐Box Binding Homeobox (ZEB) families of TFs. These TFs are regulated by interaction with specific microRNAs (miRNAs), as miR34 and miR200. Among the several secondary metabolites produced in plants, flavonoids constitute a major group of bioactive molecules, with several described effects including antioxidant, antiinflammatory, antidiabetic, antiobesogenic, and anticancer effects. This review scrutinizes the modulatory role of flavonoids on the activity of SNAI/ZEB TFs and on their regulatory miRNAs, miR‐34, and miR‐200. The modulatory role of flavonoids can attenuate mesenchymal features and stimulate epithelial features, thereby inhibiting and reversing EMT. Moreover, this modulation is concomitant with the attenuation of signaling pathways involved in diverse processes as cell proliferation, cell growth, cell cycle progression, apoptosis inhibition, morphogenesis, cell fate, cell migration, cell polarity, and wound healing. The antimetastatic potential of these versatile compounds is emerging and represents an opportunity for the synthesis of more specific and potent agents.

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Advancements in clinical translation of flavonoid nanoparticles for cancer treatment

Cited by 20 publications

References 175 publications

Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

Apoptotic Mechanisms of Quercetin in Liver Cancer: Recent Trends and Advancements

Phytochemical-Based Nanomedicine for Targeting Tumor Microenvironment and Inhibiting Cancer Chemoresistance: Recent Advances and Pharmacological Insights

The role of flavonoids in the regulation of epithelial‐mesenchymal transition in cancer: A review on targeting signaling pathways and metastasis

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