Advancements in electrochemical biosensing for respiratory virus detection: A review

Zhao, Zhi; Huang, Changfu; Huang, Ziyu; Lin, Feng; He, Qinlin; Tao, Dan; Jaffrézic‐Renault, Nicole; Guo, Zhenzhong

doi:10.1016/j.trac.2021.116253

Cited by 95 publications

(60 citation statements)

References 105 publications

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“…Importantly, these anti-interfering results are in agreement with the monoclonal nature of the COVID-19 antibody employed. Monoclonal antibodies provide higher specificity than polyclonal counterparts because they recognize a single epitope, fact that avoids cross reactions with non-specific proteins [49] . In addition, monoclonal antibodies also favor reproducibility since they do not change batch to batch and therefore, they are widely used for clinic diagnosis [50] .…”

Section: Resultsmentioning

confidence: 99%

3D-Printed COVID-19 immunosensors with electronic readout

Muñoz

Pumera

2021

Chemical Engineering Journal

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Section: Resultsmentioning

confidence: 99%

3D-Printed COVID-19 immunosensors with electronic readout

Muñoz

Pumera

2021

Chemical Engineering Journal

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“…Electrochemical biosensors are known for their small size, cost-effectiveness, ease of use and fast response. These types of sensors are extensively used in the development of point of care devices for diagnosing viral infections [ 68 , 69 ]. Among the electrochemical techniques, screen-printed electrode (SPE) technology has aided the development of portable sensors considerably as it provides miniaturised but robust and user-friendly electrodes at low production costs [ 70 , 71 ].…”

Section: Latest Developed Biosensors For Covid-19mentioning

confidence: 99%

Emerging Biosensors to Detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Review

2021

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Coronavirus disease (COVID-19) is a global health crisis caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Real-time reverse transcriptase-polymerase chain reaction (RT-PCR) is the gold standard test for diagnosing COVID-19. Although it is highly accurate, this lab test requires highly-trained personnel and the turn-around time is long. Rapid and inexpensive immuno-diagnostic tests (antigen or antibody test) are available, but these point of care (POC) tests are not as accurate as the RT-PCR test. Biosensors are promising alternatives to these rapid POC tests. Here we review three types of recently developed biosensors for SARS-CoV-2 detection: surface plasmon resonance (SPR)-based, electrochemical and field-effect transistor (FET)-based biosensors. We explain the sensing principles and discuss the advantages and limitations of these sensors. The accuracies of these sensors need to be improved before they could be translated into POC devices for commercial use. We suggest potential biorecognition elements with highly selective target-analyte binding that could be explored to increase the true negative detection rate. To increase the true positive detection rate, we suggest two-dimensional materials and nanomaterials that could be used to modify the sensor surface to increase the sensitivity of the sensor.

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“…The straight diagonal line of a Nyquist plot at lower frequencies shows a diffusion-controlled redox process whereas the semicircle of a Nyquist plot shows at higher frequencies shows charge transfer resistance (Rct) from the electrode surface to the redox couple solution. Among electrochemical methods, EIS is commonly utilized due to its ability to reveal interaction between different layers of PAD during surface modification of the electrode [ 135 ]. Since EIS is highly sensitive, it is frequently used for label-free immunosensors [ 136 ].…”

Section: Recent Applications Of Paper-based Analytical Devices For Virus Detectionmentioning

confidence: 99%

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

Özer

Henry

2021

TrAC Trends in Analytical Chemistry

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The importance of user-friendly, inexpensive, sensitive, and selective detection of viruses has been highlighted again due to the recent Coronavirus disease 2019 (COVID-19) pandemic. Among the analytical tools, paper-based devices (PADs) have become a leading alternative for point-of-care (POC) testing. In this review, we discuss the recent development strategies and applications in nucleic acid-based, antibody/antigen-based and other affinity-based PADs using optical and electrochemical detection methods for sensing viruses. In addition, advantages and drawbacks of presented PADs are identified. Current state and insights towards future perspectives are presented regarding developing POC diagnosis platform for COVID-19. This review considers state-of-the-art technologies for further development and improvement in PADs performance for virus detection.

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Advancements in electrochemical biosensing for respiratory virus detection: A review

Cited by 95 publications

References 105 publications

3D-Printed COVID-19 immunosensors with electronic readout

3D-Printed COVID-19 immunosensors with electronic readout

Emerging Biosensors to Detect Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): A Review

Paper-based analytical devices for virus detection: Recent strategies for current and future pandemics

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