Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications

Ammad, Muhammad; Javed, Zeeshan; Sadia, Haleema; Ahmed, Rais; Akbar, Ali; Nadeem, Tariq; Calina, Daniela; Sharifi-Rad, Javad

doi:10.1007/s12032-024-02534-y

Med Oncol

2024

DOI: 10.1007/s12032-024-02534-y

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Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications

Muhammad Ammad,

Zeeshan Javed,

Haleema Sadia

et al.

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Cited by 2 publications

References 72 publications

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Non-coding RNAs in Cancer: Mechanistic insights and therapeutic implications

John,

Almulla,

Elboughdiri

et al. 2025

Pathology - Research and Practice

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Non-coding RNAs in Cancer: Mechanistic insights and therapeutic implications

John,

Almulla,

Elboughdiri

et al. 2025

Pathology - Research and Practice

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LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer

Verma,

Siddharth,

Yende

et al. 2024

Cells

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Breast cancer is a heterogeneous disease comprising multiple molecularly distinct subtypes with varied prevalence, prognostics, and treatment strategies. Among them, triple-negative breast cancer, though the least prevalent, is the most aggressive subtype, with limited therapeutic options. Recent emergence of competing endogenous RNA (ceRNA) networks has highlighted how long noncoding RNAs (lncRNAs), microRNAs (miRs), and mRNA orchestrate a complex interplay meticulously modulating mRNA functionality. Focusing on TNBC, this study aimed to construct a ceRNA network using differentially expressed lncRNAs, miRs, and mRNAs. We queried the differentially expressed lncRNAs (DElncRNAs) between TNBC and luminal samples and found 389 upregulated and 386 downregulated lncRNAs, including novel transcripts in TNBC. DElncRNAs were further evaluated for their clinical, functional, and mechanistic relevance to TNBCs using the lnc2cancer 3.0 database, which presented LUCAT1 (lung cancer-associated transcript 1) as a putative node. Next, the ceRNA network (lncRNA–miRNA–mRNA) of LUCAT1 was established. Several miRNA–mRNA connections of LUCAT1 implicated in regulating stemness (LUCAT1-miR-375-Yap1, LUCAT1-miR181-5p-Wnt, LUCAT1-miR-199a-5p-ZEB1), apoptosis (LUCAT1-miR-181c-5p-Bcl2), drug efflux (LUCAT1-miR-200c-ABCB1, LRP1, MRP5, MDR1), and sheddase activities (LUCAT1-miR-493-5p-ADAM10) were identified, indicating an intricate regulatory mechanism of LUCAT1 in TNBC. Indeed, LUCAT1 silencing led to mitigated cell growth, migration, and stem-like features in TNBC. This work sheds light on the LUCAT1 ceRNA network in TNBC and implies its involvement in TNBC growth and progression.

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Advancements in long non-coding RNA-based therapies for cancer: targeting, delivery, and clinical implications

Cited by 2 publications

References 72 publications

Non-coding RNAs in Cancer: Mechanistic insights and therapeutic implications

Non-coding RNAs in Cancer: Mechanistic insights and therapeutic implications

LUCAT1-Mediated Competing Endogenous RNA (ceRNA) Network in Triple-Negative Breast Cancer

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