This study explores a multidisciplinary design optimization method for the conceptual design of hypersonic aircraft. By integrating analysis methods into the optimization problem, the design of the aircraft and its flight trajectory are successfully optimized. In addition, the use of approximation models to accelerate time-consuming analyses without losing accuracy is proposed. Moreover, because aerodynamic heating is expected to be significantly higher during high-speed flights, the heating effects of the hypersonic aircraft are evaluated. Finally, the characteristics of the optimal solution are investigated, and the effectiveness of the proposed multidisciplinary optimization is confirmed.