Advancements in neuroactive peptides in seizures

Janković, Slobodan; Đešević, Miralem

doi:10.1080/14737175.2022.2031983

Cited by 4 publications

(2 citation statements)

References 157 publications

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“…Peptides are molecules that may have a high potential for the treatment and prevention of epileptogenesis, as they are easily absorbed by the blood-brain barrier due to their small size, and they interact with specific targets, promoting a neuroprotective effect [83]. Arginine and lysine-rich cationic peptides exhibit a range of biological activities, including immunomodulation, the blockade of ion channels, and tropism of membranes with lytic or cell penetration action, contributing to potential permeability and access to the central nervous system [84][85][86][87].…”

Section: New Therapeutic Targets and Pharmacological Strategiesmentioning

confidence: 99%

Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy

Boleti,

Cardoso,

Frihling

et al. 2024

Brain Sciences

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Epilepsy represents a condition in which abnormal neuronal discharges or the hyperexcitability of neurons occur with synchronicity, presenting a significant public health challenge. Prognostic factors, such as etiology, electroencephalogram (EEG) abnormalities, the type and number of seizures before treatment, as well as the initial unsatisfactory effects of medications, are important considerations. Although there are several third-generation antiepileptic drugs currently available, their multiple side effects can negatively affect patient quality of life. The inheritance and etiology of epilepsy are complex, involving multiple underlying genetic and epigenetic mechanisms. Different neurotransmitters play crucial roles in maintaining the normal physiology of different neurons. Dysregulations in neurotransmission, due to abnormal transmitter levels or changes in their receptors, can result in seizures. In this review, we address the roles played by various neurotransmitters and their receptors in the pathophysiology of epilepsy. Furthermore, we extensively explore the neurological mechanisms involved in the development and progression of epilepsy, along with its risk factors. Furthermore, we highlight the new therapeutic targets, along with pharmacological and non-pharmacological strategies currently employed in the treatment of epileptic syndromes, including drug interventions employed in clinical trials related to epilepsy.

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Section: New Therapeutic Targets and Pharmacological Strategiesmentioning

confidence: 99%

Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy

Boleti,

Cardoso,

Frihling

et al. 2024

Brain Sciences

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“…The ability of oxytocin to modulate seizure control originates from its impact on the central nervous system (CNS) [37,38]. Oxytocin receptors, including the hippocampus and amygdala, are present throughout the brain and have been linked to both pro-and anticonvulsive characteristics, which appear to be dose-or time-dependent [39,40]. Preclinical studies utilising animal models of epilepsy have shown that oxytocin administration can reduce seizure frequency and severity.…”

Section: Introductionmentioning

confidence: 99%

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Makhado,

Gertie Makhado

2024

Oxytocin and Social Function

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Epilepsy is a neurological disorder characterised by recurrent seizures, which can significantly impact patient’s quality of life. While current management strategies for epilepsy, such as antiepileptic drugs and surgery, are effective for many patients, there is a need for novel therapies that can provide better seizure control and improve patients’ outcomes. Oxytocin, a neuropeptide known for its role in social bonding and trust, has emerged as a promising therapy for epilepsy. Preclinical studies have shown that oxytocin can reduce seizure activity and improve seizure outcomes in animal models of epilepsy. In contrast, clinical studies have suggested that oxytocin may reduce seizure frequency and severity in some epilepsy patients. This chapter reviews the current knowledge of oxytocin and epilepsy, including the potential mechanisms of oxytocin’s antiepileptic effects, the limitations and challenges of clinical studies, and future research directions and implications. The chapter also discusses the broader impact of oxytocin research on understanding social behaviour and neurological disorders. Overall, the chapter highlights the potential of oxytocin as a novel therapy for epilepsy management and underscores the need for further research.

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Conducting polymer PEDOTs for biomedical application

Zhou,

Zhu,

et al. 2024

Synthetic Metals

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Advancements in neuroactive peptides in seizures

Cited by 4 publications

References 157 publications

Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy

Pathophysiology to Risk Factor and Therapeutics to Treatment Strategies on Epilepsy

The Love Hormone and Seizure Control: A Review of Oxytocin’s Impact on Epilepsy Management

Conducting polymer PEDOTs for biomedical application

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