Advancements in Osteoporosis Imaging, Screening, and Study of Disease Etiology

Tse, J. S.; Smith, Ainsley; Kuczynski, Michael T.; Kaketsis, Daphne A; Manske, Sarah L.

doi:10.1007/s11914-021-00699-3

Cited by 9 publications

(2 citation statements)

References 88 publications

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“…Although outside the scope of this review, CT scans can be further used for bone strength estimations using finite element modelling and/or texture analysis [12,13]. Previous reviews have summarized the use of opportunistic CT analysis specifically for the clinical assessment of osteoporosis [14][15][16][17][18]; however, measurements of vBMD from secondary CT analysis can also facilitate musculoskeletal research.…”

Section: Introductionmentioning

confidence: 99%

Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis

et al. 2023

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Computed tomography (CT) offers advanced biomedical imaging of the body and is broadly utilized for clinical diagnosis. Traditionally, clinical CT scans have not been used for volumetric bone mineral density (vBMD) assessment; however, computational advances can now leverage clinically obtained CT data for the secondary analysis of bone, known as opportunistic CT analysis. Initial applications focused on using clinically acquired CT scans for secondary osteoporosis screening, but opportunistic CT analysis can also be applied to answer research questions related to vBMD changes in response to various disease states. There are several considerations for opportunistic CT analysis, including scan acquisition, contrast enhancement, the internal calibration technique, and bone segmentation, but there remains no consensus on applying these methods. These factors may influence vBMD measures and therefore the robustness of the opportunistic CT analysis. Further research and standardization efforts are needed to establish a consensus and optimize the application of opportunistic CT analysis for accurate and reliable assessment of vBMD in clinical and research settings. This review summarizes the current state of opportunistic CT analysis, highlighting its potential and addressing the associated challenges.

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Section: Introductionmentioning

confidence: 99%

Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis

et al. 2023

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“…Quantitative computed tomography (QCT), which was initially introduced by Harry Genant and Douglas Boyd in 1977 [ 14 ], has become an alternative technique of DXA to determine BMD [ 12 ]. QCT is accepted to detect and monitor osteoporosis over time [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Performance of iCare quantitative computed tomography in bone mineral density assessment of the hip and vertebral bodies in European spine phantom

Liu,

Zhu,

et al. 2023

J Orthop Surg Res

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Background Osteoporosis is a systemic bone disease which can increase the risk of osteoporotic fractures. Dual-energy X-ray absorptiometry (DXA) is considered as the clinical standard for diagnosing osteoporosis by detecting the bone mineral density (BMD) in patients, but it has flaws in distinguishing between calcification and other degenerative diseases, thus leading to inaccurate BMD levels in subjects. Mindways quantitative computed tomography (Mindways QCT) is a classical QCT system. Similar to DXA, Mindways QCT can directly present the density of trabecular bone, vascular or tissue calcification; therefore, it is more accurate and sensitive than DXA and has been widely applied in clinic to evaluate osteoporosis. iCare QCT osteodensitometry was a new phantom-based QCT system, recently developed by iCare Inc. (China). It has been gradually applied in clinic by its superiority of taking 3-dimensional BMD of bone and converting BMD values to T value automatically. This study aimed at evaluating the osteoporosis detection rate of iCare QCT, compared with synchronous Mindways QCT (USA). Methods In this study, 131 patients who underwent hip phantom-based CT scan were included. Bone mineral density (BMD) of the unified region of interests (ROI) defined at the European spine phantom (ESP, German QRM) including L1 (low), L2 (medium), and L3 (high) vertebral bodies was detected for QCT quality control and horizontal calibration. Every ESP scan were taken for 10 times, and the mean BMD values measured by iCare QCT and Mindways QCT were compared. Hip CT scan was conducted with ESP as calibration individually. T-scores gained from iCare QCT and Mindways QCT were analyzed with Pearson correlation test. The detection rates of osteoporosis were compared between iCare QCT and Mindways QCT. The unified region of interests (ROI) was delineated in the QCT software. Results The results showed that there was no significant difference between iCare QCT and Mindways QCT in the evaluation of L1, L2, and L3 vertebrae bodies in ESP. A strong correlation between iCare QCT and Mindways QCT in the assessment of hip T-score was found. It was illustrated that iCare QCT had a higher detection rate of osteoporosis with the assessment of hip T-score than Mindways QCT did. In patients < 50 years subgroup, the detection rate of osteoporosis with iCare QCT and Mindways QCT was equal. In patients ≥ 50 years subgroup, the detection rate of osteoporosis with iCare QCT (35/92, 38.0%) was higher than that with Mindways QCT. In female subgroup, the detection rate of osteoporosis with iCare QCT was significantly higher than Mindways QCT. In male subgroup, the detection rate of osteoporosis with iCare QCT was also markedly higher than Mindways QCT. The detection rate of osteoporosis by iCare QCT was higher than Mindways QCT with hip bone assessment. Of course, the results of the present study remain to be further verified by multicenter studies in the future.

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Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics

Requist,

Mills,

Carroll

et al. 2024

Curr Osteoporos Rep

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Advancements in Osteoporosis Imaging, Screening, and Study of Disease Etiology

Cited by 9 publications

References 88 publications

Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis

Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis

Performance of iCare quantitative computed tomography in bone mineral density assessment of the hip and vertebral bodies in European spine phantom

Quantitative Skeletal Imaging and Image-Based Modeling in Pediatric Orthopaedics

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