Advancements in tissue engineering for articular cartilage regeneration

Chen, Maohua; Jiang, Zhiyuan; Zou, Xiuyuan; You, Xiaobo; Cai, Zhen; Huang, Jinming

doi:10.1016/j.heliyon.2024.e25400

Cited by 12 publications

(3 citation statements)

References 213 publications

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“…3D printing technology, also known as additive manufacturing, allows precise control over the composition and spatial distribution of cells and biomaterials to create scaffolds for tissue repair and regeneration . It involves stacking layers of biologically active materials filled with cells and growth factors to create highly biomimetic tissue microenvironments, structures, blood vessels, and functional artificial organs . Evolving 3D bioprinting approaches have resulted in a number of different printing strategies, including free-form reversible embedding printing of suspended hydrogels, extrusion-based multimaterial point-dispensing printing, void-free 3D bioprinting, and layer-by-layer alternating bioprinting with a double mesh for tissue analogues.…”

Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

“…TGF-β is a multifunctional chondroblast growth factor that promotes the secretion of collagen II and proteoglycans. It also plays a critical role in maintaining of homeostasis between subchondral bone and articular cartilage . BMPs are involved in several events during bone morphogenesis, including bone remodelling, bone formation, chondrogenesis, and mesenchymal cell infiltration and proliferation. , It is mostly determined by ELISA, RT-PCR, or immunocytochemistry …”

Section: Evaluation Of Materials For the Treatment Of Osteochondral D...mentioning

confidence: 99%

“… 51 It involves stacking layers of biologically active materials filled with cells and growth factors to create highly biomimetic tissue microenvironments, structures, blood vessels, and functional artificial organs. 138 Evolving 3D bioprinting approaches have resulted in a number of different printing strategies, including free-form reversible embedding printing of suspended hydrogels, extrusion-based multimaterial point-dispensing printing, void-free 3D bioprinting, and layer-by-layer alternating bioprinting with a double mesh for tissue analogues. As tissues contain multiple structures and diverse cells, and cell phenotype is sensitive to the biochemical and mechanical properties of the microenvironment, bioinks for 3D bioprinting are becoming increasingly important for the generation of multiple structures and diverse cell-engineered tissues.…”

Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

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Materials Suitable for Osteochondral Regeneration

Novotná,

Franková

2024

ACS Omega

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Osteochondral defects affect articular cartilage, calcified cartilage, and subchondral bone. The main problem that they cause is a different behavior of cell tissue in the osteochondral and bone part. Articular cartilage is composed mainly of collagen II, glycosaminoglycan (GAG), and water, and has a low healing ability due to a lack of vascularization. However, bone tissue is composed of collagen I, proteoglycans, and inorganic composites such as hydroxyapatite. Due to the discrepancy between the characters of these two parts, it is difficult to find materials that will meet all the structural and other requirements for effective regeneration. When designing a scaffold for an osteochondral defect, a variety of materials are available, e.g., polymers (synthetic and natural), inorganic particles, and extracellular matrix (ECM) components. All of them require the accurate characterization of the prepared materials and a number of in vitro and in vivo tests before they are applied to patients. Taken in concert, the final material needs to mimic the structural, morphological, chemical, and cellular demands of the native tissue. In this review, we present an overview of the structure and composition of the osteochondral part, especially synthetic materials with additives appropriate for healing osteochondral defects. Finally, we summarize in vitro and in vivo methods suitable for evaluating materials for restoring osteochondral defects.

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Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

Section: Evaluation Of Materials For the Treatment Of Osteochondral D...mentioning

confidence: 99%

Section: Materials Suitable For Healing Osteochondral Defectsmentioning

confidence: 99%

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Materials Suitable for Osteochondral Regeneration

Novotná,

Franková

2024

ACS Omega

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Harnessing Peptide-Based Hydrogels for Enhanced Cartilage Tissue Engineering

Pande,

Pati,

Chakraborty

2024

ACS Appl. Bio Mater.

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Cartilage tissue engineering remains a formidable challenge due to its complex, avascular structure and limited regenerative capacity. Traditional approaches, such as microfracture, autografts, and stem cell delivery, often fail to restore functional tissue adequately. Recently, there has been a surge in the exploration of new materials that mimic the extracellular microenvironment necessary to guide tissue regeneration. This review investigates the potential of peptide-based hydrogels as an innovative solution for cartilage regeneration. These hydrogels, formed via supramolecular self-assembly, exhibit excellent properties, including biocompatibility, ECM mimicry, and controlled biodegradation, making them highly suitable for cartilage tissue engineering. This review explains the structure of cartilage and the principles of supramolecular and peptide hydrogels. It also delves into their specific properties relevant to cartilage regeneration. Additionally, this review presents recent examples and a comparative analysis of various peptide-based hydrogels used for cartilage regeneration. The review also addresses the translational challenges of these materials, highlighting regulatory hurdles and the complexities of clinical application. This comprehensive investigation provides valuable insights for biomedical researchers, tissue engineers, and clinical professionals aiming to enhance cartilage repair methodologies.

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Induced pluripotent stem cells in cartilage tissue engineering: a literature review

Owaidah

2024

Bioscience Reports

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Osteoarthritis (OA) is a long-term, persistent joint disorder characterized by bone and cartilage degradation, resulting in tightness, pain, and restricted movement. Current attempts in cartilage regeneration are cell-based therapies using stem cells. Multipotent stem cells, such as mesenchymal stem cells (MSCs), and pluripotent stem cells, such as embryonic stem cells (ESCs), have been used to regenerate cartilage. However, since the discovery of human induced pluripotent stem cells (hiPSCs) in 2007, it was seen as a potential source for regenerative chondrogenic therapy as it overcomes the ethical issues surrounding the use of ESCs and the immunological and differentiation limitations of MSCs. This literature review focuses on chondrogenic differentiation and 3D bioprinting technologies using hiPSCS, suggesting them as a viable source for successful tissue engineering. Methods: A literature search was conducted using scientific search engines, PubMed, MEDLINE, and google scholar databases with the terms “Cartilage tissue engineering” and “ stem cells” to retrieve published literature on chondrogenic differentiation and tissue engineering using MSCs, ESCs, and hiPSCs. Results: hiPSCs may provide an effective and autologous treatment for focal chondral lesions, though further research is needed to explore the potential of such technologies. Conclusions: This review has provided a comprehensive overview of these technologies and the potential applications for hiPSCs in regenerative medicine.

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Advancements in tissue engineering for articular cartilage regeneration

Cited by 12 publications

References 213 publications

Materials Suitable for Osteochondral Regeneration

Materials Suitable for Osteochondral Regeneration

Harnessing Peptide-Based Hydrogels for Enhanced Cartilage Tissue Engineering

Induced pluripotent stem cells in cartilage tissue engineering: a literature review

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