Advancements in Understanding the Role of Circular RNA in Osteosarcoma

Wang, Jin; Zhang, Yan; Li, Zicai

doi:10.1007/s12033-023-00838-4

Cited by 2 publications

(1 citation statement)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Conversely, certain circRNAs have been associated with osteoclastogenesis and bone resorption, emphasizing their dual roles in bone metabolism [6,9,10]. Furthermore, the dysregulation of circRNAs has been associated with various bone disorders, including osteoporosis, osteoarthritis, osteosarcoma, and bone metastasis [9,[11][12][13][14][15][16][17][18][19][20][21]. Importantly, profiling studies have identified distinct circRNA expression patterns in diseased bone tissues compared to healthy controls, suggesting their potential utility as diagnostic and prognostic biomarkers [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Valenti,

Zerlotin,

Cominacini

et al. 2024

Cells

View full text Add to dashboard Cite

Circular RNAs (circRNAs) have emerged as pivotal regulators of gene expression with diverse roles in various biological processes. In recent years, research into circRNAs’ involvement in bone biology has gained significant attention, unveiling their potential as novel regulators and biomarkers in bone-related disorders and diseases. CircRNAs, characterized by their closed-loop structure, exhibit stability and resistance to degradation, underscoring their functional significance. In bone tissue, circRNAs are involved in critical processes such as osteogenic differentiation, osteoclastogenesis, and bone remodeling through intricate molecular mechanisms including microRNA regulation. Dysregulated circRNAs are associated with various bone disorders, suggesting their potential as diagnostic and prognostic biomarkers. The therapeutic targeting of these circRNAs holds promise for addressing bone-related conditions, offering new perspectives for precision medicine. Thus, circRNAs constitute integral components of bone regulatory networks, impacting both physiological bone homeostasis and pathological conditions. This review provides a comprehensive overview of circRNAs in bone biology, emphasizing their regulatory mechanisms, functional implications, and therapeutic potential.

show abstract

Section: Introductionmentioning

confidence: 99%

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Valenti,

Zerlotin,

Cominacini

et al. 2024

Cells

View full text Add to dashboard Cite

show abstract

Osteosarcoma in a ceRNET perspective

Mosca,

Alessio,

Di Paola

et al. 2024

J Biomed Sci

View full text Add to dashboard Cite

Osteosarcoma (OS) is the most prevalent and fatal type of bone tumor. It is characterized by great heterogeneity of genomic aberrations, mutated genes, and cell types contribution, making therapy and patients management particularly challenging. A unifying picture of molecular mechanisms underlying the disease could help to transform those challenges into opportunities.This review deeply explores the occurrence in OS of large-scale RNA regulatory networks, denominated “competing endogenous RNA network” (ceRNET), wherein different RNA biotypes, such as long non-coding RNAs, circular RNAs and mRNAs can functionally interact each other by competitively binding to shared microRNAs. Here, we discuss how the unbalancing of any network component can derail the entire circuit, driving OS onset and progression by impacting on cell proliferation, migration, invasion, tumor growth and metastasis, and even chemotherapeutic resistance, as distilled from many studies. Intriguingly, the aberrant expression of the networks components in OS cells can be triggered also by the surroundings, through cytokines and vesicles, with their bioactive cargo of proteins and non-coding RNAs, highlighting the relevance of tumor microenvironment. A comprehensive picture of RNA regulatory networks underlying OS could pave the way for the development of innovative RNA-targeted and RNA-based therapies and new diagnostic tools, also in the perspective of precision oncology.

show abstract

Advancements in Understanding the Role of Circular RNA in Osteosarcoma

Cited by 2 publications

References 96 publications

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Exploring the Role of Circular RNA in Bone Biology: A Comprehensive Review

Osteosarcoma in a ceRNET perspective

Contact Info

Product

Resources

About