Advances and applications of block-copolymer-based nanoformulations

Agrahari, Vibhuti; Agrahari, Vivek

doi:10.1016/j.drudis.2018.03.004

Cited by 58 publications

(36 citation statements)

References 90 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[73,74] Micelles (polymers) are organized auto-assembly formed in a liquid and composed of amphiphilic macromolecules, in general amphiphilic di or tri-block copolymers made of solvophilic and solvophobic blocks. Until now, various approaches have been applied to synthesize block copolymers, such as anionic, radical, cationic, ring-opening, photo, and group-transfer polymerization methods.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

“…[73] In addition, their surface could be modified with functional moieties, such as CPP for efficient cellular uptake and proteins delivery into different cell lines. In comparison with liposomes, polymersomes are more stable, easier adjusted with their stimuli-responsiveness, membrane thickness, and size.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

“…Thus, copolymer-based nanocarriers have been widely used for drugs delivery, wound dressing and tissue engineering. [73,74] Micelles (polymers) are organized auto-assembly formed in a liquid and composed of amphiphilic macromolecules, in general amphiphilic di or tri-block copolymers made of solvophilic and solvophobic blocks. These micelles could be used as the platforms for cargos delivery.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

“…In comparison with liposomes, polymersomes are more stable, easier adjusted with their stimuli-responsiveness, membrane thickness, and size. [73] In addition, their surface could be modified with functional moieties, such as CPP for efficient cellular uptake and proteins delivery into different cell lines. [81] In the same way as micelles, polymersomes could also be prepared for proteins delivery system with thermos/pH/reduction-sensitive copolymers.…”

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

See 3 more Smart Citations

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

View full text Add to dashboard Cite

Protein/antibody therapeutics have exhibited the advantages of high specificity and activity even at an extremely low concentration compared to small molecule drugs. However, they are accompanied by unfavorable physicochemical properties such as fragile tertiary structure, large molecular size, and poor penetration of the membrane, and thus the clinical use of protein drugs is hindered by inefficient delivery of proteins into the host cells. To overcome the challenges associated with protein therapeutics and enhance their biopharmaceutical applications, various protein‐loaded nanocarriers with desired functions, such as lipid nanocapsules, polymeric nanoparticles, inorganic nanoparticles, and peptides, are developed. In this review, the different strategies for intracellular delivery of proteins are comprehensively summarized. Their designed routes, mechanisms of action, and potential therapeutics in live cells or in vivo are discussed in detail. Furthermore, the perspective on the new generation of delivery systems toward the emerging area of protein‐based therapeutics is presented as well.

show abstract

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

Section: Wwwadvmatde Wwwadvancedsciencenewscommentioning

confidence: 99%

See 2 more Smart Citations

Rational Design of Nanocarriers for Intracellular Protein Delivery

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Block copolymers have been extensively studied over the last decades due to their application in different areas, such as nanotemplating, [1][2][3] separation membranes, [4] and polymeric micelles for drug delivery. [5][6][7] Several block copolymers have been reported, [8][9][10][11] among them, polystyrene-block-poly(methyl methacrylate) (PS-b-PMMA) has received great attention. [12,13] Usually, block copolymers are produced either by ionic or by reversible deactivation radical polymerization (RDRP), with the addition of distinct monomers in a sequential way, causing the first polymerized chain to act as a macroinitiator for the next portion.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and analysis of phase segregation of polystyrene‐block‐poly(methyl methacrylate) copolymer obtained by Steglich esterification from semitelechelic blocks of polystyrene and poly(methyl methacrylate)

Boni

Ferreira

Pinheiro

et al. 2020

J of Applied Polymer Sci

View full text Add to dashboard Cite

Here, an alternative route to successfully synthesize polystyrene‐block‐poly(methyl methacrylate) (PS‐b‐PMMA) is reported. Steglich esterification was used as an effective, metal free approach for coupling carboxylic terminated PS and the hydroxyl end‐functionalized PMMA chains obtained by nitroxide‐mediated polymerization and atom transfer radical polymerization, respectively. α‐Functionalization was obtained using 4,4′‐azobis(4‐cyanovaleric acid) and 2,2,2‐tribromoethanol as initiators. The synthesis of PS‐b‐PMMA was confirmed by gel permeation chromatography and nuclear magnetic resonance (NMR), while the dependence of the diffusion coefficients of the polymers (PS, PMMA, PS/PMMA blend, and PS‐b‐PMMA) with their corresponding molecular weights was discussed based on the results of atomic force microscopy‐based infrared spectroscopy, differential scanning calorimetry, and spectra of diffusion‐ordered NMR spectroscopy. Differently from PS‐b‐PMMA, a partial segregation was observed for the PS/PMMA blend, affecting its thermal behavior and diffusion coefficient. The study here presented provides an easier and efficient strategy for the synthesis of PS‐b‐PMMA and new insights into the diffusion of polymers.

show abstract

Improved Treatment on Ocular Inflammation with Rationally Designed Thermoresponsive Nanocomposite Formulation

Zhang

Fang

Sun

et al. 2021

Advanced Therapeutics

View full text Add to dashboard Cite

Cataract is the principal cause of preventable blindness in older people globally. Intraocular surgeries stimulate multiple postoperative inflammatory responses. The current clinical treatment by dropping prednisolone acetate (PA) and levofloxacin (LF) suffers from drawbacks, such as low bioavailability and poor patient compliance. This study aims to develop a rationally designed thermoresponsive formulation combining PA and LF using nancomposites of mesoporous silica nanoparticle (MSN) and thermo-nanogel (thermogel)

show abstract

Advances and applications of block-copolymer-based nanoformulations

Cited by 58 publications

References 90 publications

Rational Design of Nanocarriers for Intracellular Protein Delivery

Rational Design of Nanocarriers for Intracellular Protein Delivery

Synthesis and analysis of phase segregation of polystyrene‐block‐poly(methyl methacrylate) copolymer obtained by Steglich esterification from semitelechelic blocks of polystyrene and poly(methyl methacrylate)

Improved Treatment on Ocular Inflammation with Rationally Designed Thermoresponsive Nanocomposite Formulation

Contact Info

Product

Resources

About