Advances and challenges of immunotherapies in NK/T cell lymphomas

He, Ling; Chen, Na; Dai, Lei; Peng, Xingchen

doi:10.1016/j.isci.2023.108192

Cited by 3 publications

(1 citation statement)

References 121 publications

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“…The prognosis is worse for patients with HL and diffuse large B-cell lymphoma (DLBCL) who are EBV + than EBV - . ( 10 ) NK/T-cell lymphoma (NKTCL), a rare subtype of EBV-associated non-Hodgkin lymphoma (NHL), has similarly shown poorer outcomes ( 11 ).…”

Section: Epstein-barr Virusmentioning

confidence: 99%

Carcinogenic mechanisms of virus-associated lymphoma

Zhang,

Guo,

Zhan

et al. 2024

Front. Immunol.

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The development of lymphoma is a complex multistep process that integrates numerous experimental findings and clinical data that have not yet yielded a definitive explanation. Studies of oncogenic viruses can help to deepen insight into the pathogenesis of lymphoma, and identifying associations between lymphoma and viruses that are established and unidentified should lead to cellular and pharmacologically targeted antiviral strategies for treating malignant lymphoma. This review focuses on the pathogenesis of lymphomas associated with hepatitis B and C, Epstein-Barr, and human immunodeficiency viruses as well as Kaposi sarcoma-associated herpesvirus to clarify the current status of basic information and recent advances in the development of virus-associated lymphomas.

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Section: Epstein-barr Virusmentioning

confidence: 99%

Carcinogenic mechanisms of virus-associated lymphoma

Zhang,

Guo,

Zhan

et al. 2024

Front. Immunol.

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The Effect of a Prior Malignancy on the Prognosis of Patients With Extranodal NK/T-Cell Lymphoma

Xiang,

Wang,

Liu

2024

American Journal of Therapeutics

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A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

Klein,

Kollmann,

Hiesinger

et al. 2024

Blood

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Patients with T- and NK-cell neoplasms frequently have somatic STAT5B gain-of-function mutations. The most frequent STAT5B mutation is STAT5BN642H, which is known to drive murine T-cell leukemia although its role in NK-cell malignancies is unclear. Introduction of the STAT5BN642H mutation into human NK-cell lines enhances their potential to induce leukemia in mice. We have generated a mouse model that enables tissue-specific expression of STAT5BN642H and have selectively expressed the mutated STAT5B in hematopoietic cells (N642Hvav/+) or exclusively in NK cells (N642HNK/NK). All N642Hvav/+ mice rapidly develop an aggressive T-/NK T-cell leukemia, whereas N642HNK/NK mice display an indolent NK-large granular lymphocytic leukemia (NK-LGLL) that progresses to an aggressive leukemia with age. Samples from NK-cell leukemia patients have a distinctive transcriptional signature driven by mutant STAT5B, which overlaps with that of murine leukemic N642HNK/NK NK cells. We have generated the first reliable STAT5BN642H-driven pre-clinical mouse model that displays an indolent NK-LGLL progressing to aggressive NK-cell leukemia. This novel in vivo tool will enable us to explore the transition from an indolent to an aggressive disease and will thus permit the study of prevention and treatment options for NK-cell malignancies. -

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Advances and challenges of immunotherapies in NK/T cell lymphomas

Cited by 3 publications

References 121 publications

Carcinogenic mechanisms of virus-associated lymphoma

Carcinogenic mechanisms of virus-associated lymphoma

The Effect of a Prior Malignancy on the Prognosis of Patients With Extranodal NK/T-Cell Lymphoma

A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia

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