Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment

Gil-Martínez, Marta; Lorente-Sorolla, Clara; Naharro, Sara; Rodrigo‐Muñoz, José Manuel; Pozo, Victoria del

doi:10.3390/ijms24021628

Cited by 12 publications

(22 citation statements)

References 107 publications

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“…Currently, many publications show miRNAs as potential asthma diagnostic biomarkers [13,[15][16][17]. Few studies have also drawn attention to the relationship between miRNAs and a particular therapeutic regimen.…”

Section: Mirnas and Individual Groups Of Drugs Used In Asthma (Glucoc...mentioning

confidence: 99%

“…Their broad impact on the processes involved in the pathogenesis of asthma has been confirmed (including the proliferation of smooth muscle cells, increased mucus production, collagen, and overactivity of the respiratory tract) [12]. These are small, non-coding RNA biomolecules, 18-25 nucleotides long, and regulate gene expression at the posttranscriptional level by binding to the target mRNA (messenger RNA) [13]. Due to their role in multiple cellular processes, such as inflammatory and immunomodulatory processes, they are an important future target of therapeutic activities leading to increased and improved sensitivity to steroid therapy [14].…”

Section: Introductionmentioning

confidence: 99%

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miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

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Asthma is a chronic inflammatory disease of the airways characterized by shortness of breath, chest tightness, coughing, and wheezing. For several decades (approximately 30 years), miRNAs and their role in asthma have been of constant interest among scientists. These small, non-coding RNA fragments, 18–25 nucleotides long, regulate gene expression at the post-transcriptional level by binding to the target mRNA. In this way, they affect several biological processes, e.g., shaping airway structures, producing cytokines and immune mediators, and controlling defense mechanisms. Publications confirm their potential role in the diagnosis and monitoring of the disease, but only some articles address the use of miRNAs in the treatment of asthma. The following paper reviews the latest available studies and presents miRNAs as a useful tool for predicting the effectiveness of the included treatment, early diagnosis of exacerbations, and in assessing patient compliance for different groups of drugs used in asthma. The latest known pathways underlying the pathogenesis of the disease, which are associated with a change in miRNA expression, may be precise targets of therapeutic activity in the future.

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Section: Mirnas and Individual Groups Of Drugs Used In Asthma (Glucoc...mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

miRNAs as Modern Biomarkers in Asthma Therapy

Kierbiedź-Guzik¹,

Sozańska

2023

IJMS

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“…Mir-21, mir-223, and Let-7a were selected for their role in the development and pathogenesis of different forms of asthma. Recent asthma-specific findings show their role as significant contributor to the asthma process [20][21][22]. Further studies on more miRNAs will be required.…”

Section: Limitations Of the Studymentioning

confidence: 99%

“…Despite extensive investigations into the role of miRNAs in the development of asthma [21][22][23], to date, studies on the functioning of exosomal miRNAs in this disease are lacking [24]. Based on the above, we therefore believe that alterations of intracellular miRNAs and circulating miRNAs can probably be implicated in the etiopathogenesis of asthma and of severe asthma.…”

Section: Introductionmentioning

confidence: 99%

MiRNA and Exosomal miRNA as New Biomarkers Useful to Phenotyping Severe Asthma

Soccio,

Moriondo,

Lacedonia

et al. 2023

Biomolecules

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Severe asthma (SA) is a chronic inflammatory disease of the airways. Due to the extreme heterogeneity of symptoms, new biomarkers are currently needed. MiRNAs are non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In biological fluids, miRNAs are contained within exosomes, vesicles capable of giving miRNAs considerable stability and resistance to degradation by RNAses. The main function attributed to the exosomes is intercellular communication. The goal of our study was to analyze intracellular and exosomal miRNAs in order to demonstrate their potential use as non-invasive biomarkers of asthma by showing, in particular, their role in SA. We detected miRNAs by qRT-PCR in both serum and serum-derived-exosomes of asthmatic patients and healthy controls. The levels of almost all analyzed intracellular miRNAs (miR-21, miR-223, and let-7a) were greater in asthmatic patients vs. healthy control, except for miR-223. In detail, miR-21 was greater in SA, while let-7a increased in mild-to-moderate asthma. On the other hand, in exosomes, all analyzed miRNAs were higher in SA. This study identified a series of miRNAs involved in SA, highlighting their potential role in asthma development and progression. These results need validation on a larger cohort.

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“…Despite the accumulated evidence showing that obesity is a risk factor for developing severe asthma, the possibility that this effect could be mediated, at least in part, via modification of the expression of genes associated with asthma severity has been poorly studied. Some studies analyzed microRNA expression and found higher levels of hsa-miR-155-5p and 223-5p in moderate asthmatics and obese subjects compared to healthy controls [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Obesity on the Expression of Genes Associated with Severe Asthma—A Pilot Study

Bantulà

Arismendi

Tubita

et al. 2023

JCM

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Asthma is a complex condition resulting from the interaction of genes and environment. Obesity is a risk factor to develop asthma and contributes to poor response to asthma therapy and severity. The aim of the study was to evaluate the effect of obesity on the expression levels of genes previously associated with severe asthma. Three groups of subjects were studied: non-obese asthmatics (NOA), obese asthma patients (OA), and non-asthmatic obese subjects (O). Previously reported overexpressed (IL-10, MSR1, PHLDA1, SERPINB2, and CD86) and underexpressed genes (CHI3L1, CPA3, IL-8, and PI3) in severe asthma were analyzed by RT-qPCR in peripheral blood mononuclear cells (PBMCs). In the overexpressed genes, obesity significantly decreased the expression of MSR1 and PHLDA1 and had no effects on CD86, IL-10, and SERPINB2. In underexpressed genes, obesity did not affect PI3, CHI3L1, and IL-8 and significantly reduced CPA3 expression. The results of this study show that obesity should be included among the known factors that can contribute toward modifying the expression of genes associated with asthma and, in particular, severe asthma.

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Advances and Highlights of miRNAs in Asthma: Biomarkers for Diagnosis and Treatment

Cited by 12 publications

References 107 publications

miRNAs as Modern Biomarkers in Asthma Therapy

miRNAs as Modern Biomarkers in Asthma Therapy

MiRNA and Exosomal miRNA as New Biomarkers Useful to Phenotyping Severe Asthma

Effect of Obesity on the Expression of Genes Associated with Severe Asthma—A Pilot Study

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