Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Xu, Zejun; Han, Shuyan; Z, Gu; Wu, Jun

doi:10.1002/adhm.201901502

Cited by 498 publications

(337 citation statements)

References 125 publications

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“…In this study, alginate, whose biosafety has been extensively verified, was employed to develop a biomaterial to solve the problem of repairing skin defects in complex clinical situations. 4 − 6 Self-healing hydrogels pose the property that self-heal after rupture. 7 , 8 Skin tissue is easily distorted, stretched, and deformed during the movement of the limb.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Alginate Hydrogel Protects and Heals Skin Defects in Complex Clinical Situations

Lü

Bao

et al. 2020

ACS Omega

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Skin defects, soft tissue damage, and fractures often occur simultaneously in severe trauma. Under current medical technology, fractures can be quickly fixed by internal or external repair techniques, and early functional exercises can be performed. However, skin defects heal over a long time and can even be difficult to heal. Functional exercise may cause cutting of fresh granulation to break and impair wound healing. Functional exercise and wound healing seem to contradict each other. In this study, an alginate hydrogel was developed. With self-healing characteristics, the hydrogel tightly adhered to the wound and could self-heal breaks in the gel caused by functional exercises. These characteristics enable this hydrogel to be used in complex clinical situations to solve sports rehabilitation and skin defect repair problems. In addition, this hydrogel can slowly release strontium ions, promote angiogenesis and collagen deposition in the wound, and quickly heal the wound.

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Section: Introductionmentioning

confidence: 99%

Multifunctional Alginate Hydrogel Protects and Heals Skin Defects in Complex Clinical Situations

Lü

Bao

et al. 2020

ACS Omega

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show abstract

“…Furthermore, hydrogels have a cooling and pain-relieving effect [1]. Hydrogel bases therefore offer great potential, as they can easily be combined with various substances that facilitate wound healing and/or have anti-inflammatory properties to promote healing in chronic wounds [28]. However, there is still a lot of educational work to be done by the treating physicians to make patients aware of these benefits and to establish ideal moist wound management as a standard approach even for minor wounds.…”

Section: Discussionmentioning

confidence: 99%

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Rüther¹,

Voss²

2021

Heliyon

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Purpose Five different galenics were analyzed and compared concerning tissue breathability and gas exchange with the environment after an application period of 6 h on pig ear skin. Aim was to find the most suitable galenics for efficient moist treatment for everyday injuries (abrasions, lacerations and cuts) without influencing the transepidermal water loss. Methods A quantity of 0.1 g of the different test preparations was applied once topically to an area of 2 cm 2 . The analysis of the breathability was performed by TEWL (transepidermal water loss) measurements in the first hour after product application. The moisture retention effect was assessed by corneometry in the first 5 h after product application. Results The hydrogel preparations showed a higher breathability in contrast to a semi-occlusive ointment and petrolatum. The same applies to the moisture penetration of the skin. Here, all hydrogel formulations showed the highest tissue hydration. After 3 h an additional increase in moisture was observed for the areas treated with Tyrosur® CareExpert Wound Gel and the ointment. Conclusion In contrast to petrolatum and the semi-occlusive ointment, treatment with the hydrogels led to a preservation of the breathability and good moistening of the tissue, which is due to the galenics of the gels consisting of water, carbomer and propylene glycol. The increase in moisture after 3 h in areas treated with Tyrosur® CareExpert Wound Gel and the semi-occlusive ointment indicates a sustained moisturizing effect mediated by dexpanthenol.

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“…Previous studies have shown that BG can release Si ions to promote angiogenesis [ 13 ]. In addition, studies have shown that diabetic wound is often the most suitable place for microbial colonization, because of its hyperglycemia, which can easily give rise to wound infection [ 27 ]. CeO 2 can separate the outer membrane from the cytoplasmic membrane to inhibit the growth of bacteria [ 33 ].…”

Section: Discussionmentioning

confidence: 99%

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

et al. 2021

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Diabetic foot wound healing is a major clinical problem due to impaired angiogenesis and bacterial infection. Therefore, an effective regenerative dressing is desiderated with the function of promoting revascularization and anti-bacteria. Herein, a multifunctional injectable composite hydrogel was prepared by incorporation of the cerium-containing bioactive glass (Ce-BG) into Gelatin methacryloyl (GelMA) hydrogel. The Ce-BG was synthesized by combining sol-gel method with template method, which maintained spherical shape, chemical structure and phase constitution of bioactive glass (BG). The Ce-BG/GelMA hydrogels had good cytocompatibility, promoted endothelial cells migration and tube formation by releasing Si ion. In vitro antibacterial tests showed that 5 mol % CeO2-containing bioactive glass/GelMA (5/G) composite hydrogel exhibited excellent antibacterial properties. In vivo study demonstrated that the 5/G hydrogel could significantly improve wound healing in diabetic rats by accelerating the formation of granulation tissue, collagen deposition and angiogenesis. All in all, these results indicate that the 5/G hydrogel could enhance diabetic wound healing. Therefore, the development of multifunctional materials with antibacterial and angiogenic functions is of great significance to promote the repair of diabetic wound healing.

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Advances and Impact of Antioxidant Hydrogel in Chronic Wound Healing

Cited by 498 publications

References 125 publications

Multifunctional Alginate Hydrogel Protects and Heals Skin Defects in Complex Clinical Situations

Multifunctional Alginate Hydrogel Protects and Heals Skin Defects in Complex Clinical Situations

Hydrogel or ointment? Comparison of five different galenics regarding tissue breathability and transepidermal water loss

Multifunctional Injectable Hydrogel Loaded with Cerium-Containing Bioactive Glass Nanoparticles for Diabetic Wound Healing

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