Advances and novel developments in mechanisms of allergic inflammation

Han, Xiaorui; Krempski, James; Nadeau, Kari

doi:10.1111/all.14632

Cited by 81 publications

(73 citation statements)

References 118 publications

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“…The World Health Organization (WHO) has identified allergic diseases as one of the three major diseases that need focal prevention and a cure; moreover, allergic diseases are considered a current serious global problem ( Nwaru and Virtanen, 2017 ). Allergic diseases, mainly asthma, food allergy (FA), allergic rhinitis (AR), eczema and so on, are traditionally referred to as immediate or type 1 hypersensitivity reactions, with IgE as a critical factor ( Han et al, 2020 ; Justiz Vaillant et al, 2021 ). This kind of anaphylactic reaction is mediated by IgE antibodies that are produced by the immune system in response to environmental proteins which are termed allergens including pollens, animal danders, or dust mites.…”

Section: Introductionmentioning

confidence: 99%

Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota

Dong

Yang

et al. 2021

Front. Physiol.

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Allergic diseases comprise a genetically heterogeneous cluster of immunologically mediated diseases, including asthma, food allergy (FA), allergic rhinitis (AR) and eczema, that have become major worldwide health problems. Over the past few decades, the spread of allergic diseases has displayed an increasing trend, and it has been reported that 22% of 1.39 billion people in 30 countries have a type of allergic disease. Undoubtedly, allergic diseases, which can be chronic, with significant morbidity, mortality and dynamic progression, impose major economic burdens on society and families; thus, exploring the cause of allergic diseases and reducing their prevalence is a top priority. Recently, it has been reported that the gastrointestinal (GI) microbiota can provide vital signals for the development, function, and regulation of the immune system, and the above-mentioned contributions make the GI microbiota a key player in allergic diseases. Notably, the GI microbiota is highly influenced by the mode of delivery, infant diet, environment, antibiotic use and so on. Specifically, changes in the environment can result in the dysbiosis of the GI microbiota. The proper function of the GI microbiota depends on a stable cellular composition which in the case of the human microbiota consists mainly of bacteria. Large shifts in the ratio between these phyla or the expansion of new bacterial groups lead to a disease-promoting imbalance, which is often referred to as dysbiosis. And the dysbiosis can lead to alterations of the composition of the microbiota and subsequent changes in metabolism. Further, the GI microbiota can affect the physiological characteristics of the human host and modulate the immune response of the host. The objectives of this review are to evaluate the development of the GI microbiota, the main drivers of the colonization of the GI tract, and the potential role of the GI microbiota in allergic diseases and provide a theoretical basis as well as molecular strategies for clinical practice.

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Section: Introductionmentioning

confidence: 99%

Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota

Dong

Yang

et al. 2021

Front. Physiol.

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“…These inhaled allergens include pollens, dust mites, animal dander and mold ( 5 ). Multiple inflammatory cells, such as B and T cells, basophils and mast cells, are involved in this inflammatory process ( 6 ). AR has a severe impact on the quality of life of patients.…”

Section: Introductionmentioning

confidence: 99%

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

et al. 2021

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allergic rhinitis (ar) is an ige-mediated upper airway disease with a high worldwide prevalence. Microrna (mir)-205-5p upregulation has been observed in ar; however, its role is poorly understood. The aim of the present study was to investigate the effect of mir-205-5p on AR-associated inflammation. To establish an AR model, BalB/c mice were sensitized using an intraperitoneal injection of ovalbumin (oVa) on days 0, 7 and 14, followed by intranasal challenge with oVa on days 21-27. a lentiviral sponge for mir-205-5p was used to downregulate mir-205-5p in vivo via intranasal administration on days 20-26. reverse transcription-quantitative Pcr revealed that mir-205-5p was upregulated in ar mice. notably, mir-205-5p knockdown reduced the frequency of nose-rubbing and sneezing, and attenuated pathological alterations in the nasal mucosa. The levels of total and OVA-specific IgE, cytokines IL-4, IL-5 and IL-13, and inflammatory cells, were decreased by miR-205-5p knockdown in ar mice. in addition, mir-205-5p knockdown inhibited nucleotide-binding oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome activation by reducing the expression levels of nlrP3, apoptosis associated speck like protein containing a card, cleaved caspase-1 and il-1β by western blot analysis. B-cell lymphoma 6 (BCL6) was confirmed as a target of miR-205-5p by luciferase reporter assay. In conclusion, the present findings suggested that mir-205-5p knockdown may attenuate the inflammatory response in AR by targeting BCL6, which may be a potential therapeutic target for ar.

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“…Previous studies reported that house dust mite (HDM) was prevalent worldwide and the most common cause of perennial AR, especially in the southern regions of China ( Meng et al, 2019 ; Zhang and Zhang, 2019 ). Epidemiological studies showed that the prevalence of AR has increased progressively, and this clinical disorder approximately affected a billion people worldwide ( Han et al, 2020 ; Meng et al, 2020 ). AR is highly heterogeneous with a wide range of severity, which has been subjectively evaluated by many symptom scoring scales, such as the total nasal symptom score (TNSS) and visual analogue scale (VAS) ( Adamko et al, 2018 ; Shi et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite–Induced Allergic Rhinitis

et al. 2021

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Background: Macrophage migration inhibitory factor (MIF) is described as a pro-inflammatory cytokine involved in many inflammatory and allergic disorders, but the role of MIF in allergic rhinitis (AR) remains poorly clarified. The aim of this study was to investigate the association between circulating MIF levels and house dust mite (HDM)-induced AR, and evaluate MIF as a potential biomarker in reflecting disease severity and predicting the clinical response of sublingual immunotherapy (SLIT) in HDM-induced AR patients.Methods: In this study, we enrolled 160 persistent HDM-induced AR patients (AR group), including 48 mild AR patients (MAR group) and 112 moderate–severe AR patients (MSAR group), and 77 healthy controls (HC group). Circulating levels of MIF were measured by ELISA, and the relationship between MIF concentrations and disease severity was assessed. In the MSAR group, 106 patients were assigned to receive SLIT for 3 years. At the end of the study, patients were categorized into good response group and poor response group, and associations between clinical variables or biomarkers and clinical response were analyzed by the multivariate regression analysis.Results: The concentrations of serum MIF were significantly higher in AR patients than in HCs, especially in those with MSAR. Moreover, circulating MIF levels were positively correlated with TNSS, VAS, serum HDM–specific IgE, total IgE, blood eosinophil count, and blood eosinophil percentage (all p < 0.05). Eighty MSAR patients finally completed SLIT, 45 patients obtained good response, and 35 patients resulted in poor response. The serum levels of MIF were significantly lower in the good-response group than in the poor-response group (p < 0.001). The receiver operating characteristic analysis for MIF showed good accuracy for predicting clinical response of SLIT (area under the curve = 0.877, p < 0.001). The multivariate regression analysis demonstrated that serum MIF was an independent factor for SLIT responsiveness.Conclusion: Serum MIF appeared to be an important biological indicator in reflecting disease severity and an independent predictor for clinical responsiveness of SLIT in HDM-induced AR patients.

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Advances and novel developments in mechanisms of allergic inflammation

Cited by 81 publications

References 118 publications

Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota

Pathogenesis of Children’s Allergic Diseases: Refocusing the Role of the Gut Microbiota

Knockdown of miR‑205‑5p alleviates the inflammatory response in allergic rhinitis by targeting B‑cell lymphoma 6

Circulating MIF Associated With Disease Severity and Clinical Response of Sublingual Immunotherapy in House Dust Mite–Induced Allergic Rhinitis

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