Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Yi, Jianing; Liu, Luyao; Gao, Wenjie; Zeng, Jie; Chen, Yongzhi; Pang, E.; Lan, Minhuan; Yu, Chunzhao

doi:10.1039/d4tb00483c

J. Mater. Chem. B

2024

DOI: 10.1039/d4tb00483c

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Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Jianing Yi,

Luyao Liu,

Wenjie Gao

et al.

Abstract: Phototherapy, along with photothermal therapy (PTT) and photodynamic therapy (PDT), is strengthened by spatiotemporal selectivity, non-invasive, and negligible drug resistance. Phototherapy has been approved for treating superficial epidermal tumors. However,...

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Cited by 5 publications

References 161 publications

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Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Chen,

Huang,

Tong

et al. 2024

Luminescence

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Phototheranostics with near‐infrared fluorescence and reactive oxygen species generation ability and high photothermal conversion efficiency (PCE) plays a significant role in fluorescence imaging‐guided synergetic photodynamic and photothermal therapy of tumors. Here, a star molecule in organic photovoltaic materials, NCBDT‐4C with an A‐D‐A conjugated structure, was assembled with DSPE‐PEG‐NH2 to prepare water dispersive nanoparticles (NPs). The prepared NCBDT‐4Cl NPs exhibited a maximum NIR absorption peak at 764 nm and a maximum fluorescence peak at 798 nm. These NPs could generate superoxide anion, singlet oxygen (1O2), and heat under 808 nm laser irradiation. The 1O2 generation quantum yield and PCE of the NPs were 37.5% and 53.6%, respectively. The combination of photodynamic and photothermal therapy of cancer was demonstrated in vitro and in vivo. This work presents the advanced application of organic photovoltaic materials in cancer phototherapy.

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Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Chen,

Huang,

Tong

et al. 2024

Luminescence

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Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

Das

2024

Small

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Transition metal complex‐loaded nanosystems (TMCNs) represent a cutting‐edge platform for stimuli (light, ultrasound)‐responsive cancer therapies. These nanosystems, incorporating metals such as manganese(II), zinc(II), ruthenium(II), rhenium(I), iridium(III), and platinum(IV), significantly enhance the efficacy of light‐activated therapies, including photodynamic therapy (PDT) and photothermal therapy (PTT), as well as ultrasound‐activated treatments like sonodynamic therapy (SDT). TMCNs based on ruthenium(II), rhenium(I), and iridium(III) improve PDT, while manganese(II) and iridium(III) demonstrate exceptional sonosensitizing properties. In PTT, ruthenium(II) and iridium(III)‐based TMCNs efficiently absorb light and generate heat. Emerging synergistic approaches that combine SDT, PTT, PDT, chemotherapy, and immunotherapy are demonstrated to be powerful strategies for precision cancer treatment. Zinc(II), ruthenium(II), iridium(III), and platinum(IV)‐based TMCNs play a critical role in optimizing these therapies, enhancing tumor targeting, and reducing side effects. Furthermore, TMCNs can amplify immunotherapy by inducing immunogenic cell death, thus strengthening the immune response. These advances address key challenges such as tumor hypoxia and therapeutic resistance, opening new possibilities for innovative photosensitizer‐based cancer treatments. This review highlights the latest progress in TMCNs design and applications, demonstrating their potential to revolutionize stimuli‐responsive cancer therapies.

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One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu_1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT

Mehrotra,

Pal

2024

ACS Appl. Mater. Interfaces

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Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Abstract: Phototherapy, along with photothermal therapy (PTT) and photodynamic therapy (PDT), is strengthened by spatiotemporal selectivity, non-invasive, and negligible drug resistance. Phototherapy has been approved for treating superficial epidermal tumors. However,...

Cited by 5 publications

References 161 publications

Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu_1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT

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Advances and perspectives in phototherapy-based combination therapy for cancer treatment

Abstract: Phototherapy, along with photothermal therapy (PTT) and photodynamic therapy (PDT), is strengthened by spatiotemporal selectivity, non-invasive, and negligible drug resistance. Phototherapy has been approved for treating superficial epidermal tumors. However,...

Cited by 5 publications

References 161 publications

Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Photovoltaic Molecule‐Based Phototheranostics With A‐D‐A Structure for Near‐Infrared Fluorescence Imaging‐Guided Synergetic Photodynamic and Photothermal Therapy of Tumors

Transition Metal Complex‐Loaded Nanosystems: Advances in Stimuli‐Responsive Cancer Therapies

One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT

Contact Info

Product

Resources

About

One-Pot Synthesis of Tumor-Targeted Gold-Doped Cu_1.92S Plasmonic Nanodots for Enhanced NIR-Triggered, pH-Responsive PTT/PDT/CDT