Advances and Progress in Self-Healing Hydrogel and Its Application in Regenerative Medicine

Zhu, Wei; Zhang, Jinyi; Wei, Zhanqi; Zhang, Baozhong; Weng, Xisheng

doi:10.3390/ma16031215

Cited by 33 publications

(15 citation statements)

References 77 publications

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“…Biomaterials are inevitably damaged by external tension, mechanical stress, tissue activity, fatigability, etc., when filling and repairing defects in tissues such as bone, skin and muscle ( Zhu et al, 2023 ). This damage can cause the biomaterial to deform or even rupture and fracture.…”

Section: The Outstanding Advantages Of Hydrogelsmentioning

confidence: 99%

Functional hydrogels for the repair and regeneration of tissue defects

Geng

et al. 2023

Front. Bioeng. Biotechnol.

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Tissue defects can be accompanied by functional impairments that affect the health and quality of life of patients. Hydrogels are three-dimensional (3D) hydrophilic polymer networks that can be used as bionic functional tissues to fill or repair damaged tissue as a promising therapeutic strategy in the field of tissue engineering and regenerative medicine. This paper summarises and discusses four outstanding advantages of hydrogels and their applications and advances in the repair and regeneration of tissue defects. First, hydrogels have physicochemical properties similar to the extracellular matrix of natural tissues, providing a good microenvironment for cell proliferation, migration and differentiation. Second, hydrogels have excellent shape adaptation and tissue adhesion properties, allowing them to be applied to a wide range of irregularly shaped tissue defects and to adhere well to the defect for sustained and efficient repair function. Third, the hydrogel is an intelligent delivery system capable of releasing therapeutic agents on demand. Hydrogels are capable of delivering therapeutic reagents and releasing therapeutic substances with temporal and spatial precision depending on the site and state of the defect. Fourth, hydrogels are self-healing and can maintain their integrity when damaged. We then describe the application and research progress of functional hydrogels in the repair and regeneration of defects in bone, cartilage, skin, muscle and nerve tissues. Finally, we discuss the challenges faced by hydrogels in the field of tissue regeneration and provide an outlook on their future trends.

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Section: The Outstanding Advantages Of Hydrogelsmentioning

confidence: 99%

Functional hydrogels for the repair and regeneration of tissue defects

Geng

et al. 2023

Front. Bioeng. Biotechnol.

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“…Recent advancements include the development of injectable self-healing hydrogels with bioactive factor release capabilities, antibacterial properties, and on-demand gelation and dissolution characteristics. These innovative hydrogels show promise in wound care by promoting healing and addressing challenges associated with skin lesions [6]. Overall, hydrogels present a versatile and promising avenue in skin regenerative medicine, offering solutions for wound healing, tissue regeneration, and controlled drug delivery systems.…”

Section: Introductionmentioning

confidence: 99%

Development And Formulation Of Drug-Loaded Hydrogel For Skin Regenerative Potential

Sanjay,

Shanmugarajan

2024

JAZ

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Skin injuries, whether due to trauma, burns, or chronic wounds, present a significant clinical challenge, highlighting the need for innovative regenerative therapies. This study focuses on the development and formulation of a drug-loaded hydrogel as a promising approach for skin regeneration. Hydrogel is designed to provide a supportive environment for cell proliferation, migration, and differentiation, while also delivering therapeutic agents to accelerate wound healing. Various biocompatible polymers and crosslinking methods are explored to optimize the hydrogel's mechanical properties, biodegradability, and drug release kinetics. Additionally, the study investigates the efficacy of different drugs, growth factors, and bioactive molecules in promoting angiogenesis, collagen synthesis, and tissue remodeling within the hydrogel scaffold. The developed drug-loaded hydrogel holds great potential for addressing a wide range of skin injuries and advancing the field of regenerative dermatology. In summary, hydrogels represent a promising avenue in skin regenerative medicine due to their unique properties that support tissue repair, drug delivery, and wound healing processes. Ongoing research continues to explore innovative applications of hydrogels to address challenges in skin regeneration and wound treatment effectively.

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“…87,88 In contrast, autonomous SHHs usually use noncovalent interactions, either alone or in combination with other interactions, and do not require external stimuli, such as ionic bonding, hydrogen-bonding, supramolecular interactions, hydrophobic bonding, molecular diffusion, and chain entanglement. 89 Regardless of the mechanism, SHHs should be designed to match their intended application. Ideally, SHHs should respond autonomously, rapidly, and repeatedly to induce damage under mild conditions, thereby ensuring long-term use and stable function.…”

Section: Introductionmentioning

confidence: 99%

“…SHHs exhibit better fatigue resistance, reusability, hydrophilicity and responsiveness to environmental stimuli than traditional hydrogels and are therefore more suitable for regenerative medicine. 81 Originally, the concept of self-healing was inspired by the healing processes of natural tissues, such as the formation of bone callus, repair of broken ends after fracture, and formation of small wounds during skin surface healing. 82 Self-healing is a unique feature of biological systems that can restore integrity and prolong life after being damaged, 83 and most scaffolds used for BTE cannot self-heal, especially in wet environments.…”

Section: Introductionmentioning

confidence: 99%