Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

Gu, Yang; Xu, Xianhao; Wu, Yaokang; Niu, Tengfei; Liu, Yanfeng; Li, Jianghua; Du, Guocheng; Liu, Long

doi:10.1016/j.ymben.2018.05.006

Cited by 188 publications

(114 citation statements)

References 172 publications

Supporting

Mentioning

113

Contrasting

Unclassified

Order By: Relevance

“…Once the environment becomes suitable for growth and adequate nutrition, the endospores will automatically enter into the reproductive growth period and grow back into B. subtilis . In virtue of the unique differentiation ability, it has attracted tremendous attentions in biocatalysis, biological pharmacy, electrochemical fields, etc.…”

Section: Bacterium Organismsmentioning

confidence: 99%

“…Additionally, the B. subtilis can also act as the cell factory to biosynthesize the nutraceuticals, pharmaceuticals, proteins, and metal nanoparticles, which made tremendous contributions to pharmacy and biology fields. However, the systems and synthetic technologies of B. subtilis are still immature and flawed compared to the well‐studied E. coli types.…”

Section: Bacterium Organismsmentioning

confidence: 99%

See 1 more Smart Citation

Bacterium, Fungus, and Virus Microorganisms for Energy Storage and Conversion

Shen

Zhou

et al. 2019

Small Methods

View full text Add to dashboard Cite

Since rapidly increasing energy demands have aroused tremendous research activities on energy storage and conversion, microorganisms (e.g., bacteria, fungi, and viruses) have played significant roles in developing high‐performance electrodes due to their strong abilities of fast reproduction, biomineralization, gene modification, and self‐assembly. Recently, a large quantity of bacteria and fungi has been utilized as the precursors to produce heteroatom–doped carbons or as the biofactories and templates to biomineralize the metal ions to form carbon‐based composites. In addition, in virtue of easy genetic modification, nanoscale viruses with functional groups are directly used as biotemplates for the self‐assembly of the active materials. In this review, a detailed introduction on the microorganisms and their unique abilities as well as the mechanisms behind their operations are discussed. Moreover, recent progress on bacteria‐ and fungi‐derived carbon materials and their composites, as well as the virus‐templated bio‐materials as the electrodes in electrochemical fields, including batteries and electrocatalysts, are further summarized. Finally, challenges and perspectives on the development of the microorganism derivations in electrochemical fields are also provided. This review offers guidance for the rational design of advanced electrode materials from microorganisms and extend the energy systems from the man‐made to biofabrication.

show abstract

Section: Bacterium Organismsmentioning

confidence: 99%

Section: Bacterium Organismsmentioning

confidence: 99%

Bacterium, Fungus, and Virus Microorganisms for Energy Storage and Conversion

Shen

Zhou

et al. 2019

Small Methods

View full text Add to dashboard Cite

show abstract

“…This is also the case of microorganisms with a long tradition in the fields of microbiology and biotechnology that have managed to reach an industrial scale of production. The (somewhat short) list of bacterial hosts falling into this category includes Escherichia coli (Pontrelli et al ., ), Bacillus subtilis (Gu et al ., ), Streptomyces sp. (Spasic et al ., ), Pseudomonas putida (Nikel and de Lorenzo, ), and Corynebacterium glutamicum (Wendisch et al ., ), for which extensive background fundamental knowledge has been amassed.…”

Section: Desirable Properties In the Ideal Bacterial Chassis: Bridginmentioning

confidence: 99%

Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non‐traditional microorganisms

Calero

Nikel

2018

Microbial Biotechnology

243

184

View full text Add to dashboard Cite

The last few years have witnessed an unprecedented increase in the number of novel bacterial species that hold potential to be used for metabolic engineering. Historically, however, only a handful of bacteria have attained the acceptance and widespread use that are needed to fulfil the needs of industrial bioproduction - and only for the synthesis of very few, structurally simple compounds. One of the reasons for this unfortunate circumstance has been the dearth of tools for targeted genome engineering of bacterial chassis, and, nowadays, synthetic biology is significantly helping to bridge such knowledge gap. Against this background, in this review, we discuss the state of the art in the rational design and construction of robust bacterial chassis for metabolic engineering, presenting key examples of bacterial species that have secured a place in industrial bioproduction. The emergence of novel bacterial chassis is also considered at the light of the unique properties of their physiology and metabolism, and the practical applications in which they are expected to outperform other microbial platforms. Emerging opportunities, essential strategies to enable successful development of industrial phenotypes, and major challenges in the field of bacterial chassis development are also discussed, outlining the solutions that contemporary synthetic biology-guided metabolic engineering offers to tackle these issues.

show abstract

“…Many industrial microorganisms have been engineered as excellent production strains for CIB, such as Bacillus subtilis , E. coli , Corynebacterium glutamicum , Pseudomonas putida , Saccharomyces cerevisiae ( S. cerevisiae ) and so forth . Food supplements and fine chemicals such as vitamins, steroids, amino acids; biofuels including ethanol, butanol, biodiesel, and hydrogen; materials such as polyhydroxyalkanoates (PHA) and polysaccharides; polymer precursors like lactic acid (LA) succinic acid, and so forth.…”

Section: Current Industrial Biotechnologymentioning

confidence: 99%

Next‐Generation Industrial Biotechnology‐Transforming the Current Industrial Biotechnology into Competitive Processes

Chen

2019

Biotechnology Journal

View full text Add to dashboard Cite

The chemical industry has made a contribution to modern society by providing cost‐competitive products for our daily use. However, it now faces a serious challenge regarding environmental pollutions and greenhouse gas emission. With the rapid development of molecular biology, biochemistry, and synthetic biology, industrial biotechnology has evolved to become more efficient for production of chemicals and materials. However, in contrast to chemical industries, current industrial biotechnology (CIB) is still not competitive for production of chemicals, materials, and biofuels due to their low efficiency and complicated sterilization processes as well as high‐energy consumption. It must be further developed into “next‐generation industrial biotechnology” (NGIB), which is low‐cost mixed substrates based on less freshwater consumption, energy‐saving, and long‐lasting open continuous intelligent processing, overcoming the shortcomings of CIB and transforming the CIB into competitive processes. Contamination‐resistant microorganism as chassis is the key to a successful NGIB, which requires resistance to microbial or phage contaminations, and available tools and methods for metabolic or synthetic biology engineering. This review proposes a list of contamination‐resistant bacteria and takes Halomonas spp. as an example for the production of a variety of products, including polyhydroxyalkanoates under open‐ and continuous‐processing conditions proposed for NGIB.

show abstract

Advances and prospects of Bacillus subtilis cellular factories: From rational design to industrial applications

Cited by 188 publications

References 172 publications

Bacterium, Fungus, and Virus Microorganisms for Energy Storage and Conversion

Bacterium, Fungus, and Virus Microorganisms for Energy Storage and Conversion

Chasing bacterial chassis for metabolic engineering: a perspective review from classical to non‐traditional microorganisms

Next‐Generation Industrial Biotechnology‐Transforming the Current Industrial Biotechnology into Competitive Processes

Contact Info

Product

Resources

About