Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications

Capella-Monsonís, Héctor; Crum, Raphael J.; Hussey, George S.; Badylak, Stephen F.

doi:10.1016/j.addr.2024.115347

Advanced Drug Delivery Reviews

2024

DOI: 10.1016/j.addr.2024.115347

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Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications

Héctor Capella-Monsonís,

Raphael J. Crum,

George S. Hussey

et al.

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Cited by 2 publications

References 210 publications

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Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect

Luevano-Colmenero,

Rocha-Juache,

Vargas-Mancilla

et al. 2025

Biomater. Sci.

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Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect

Luevano-Colmenero,

Rocha-Juache,

Vargas-Mancilla

et al. 2025

Biomater. Sci.

View full text Add to dashboard Cite

show abstract

Application and progress of bionic scaffolds in nerve repair: a narrative review

Fang,

Nan,

Song

et al. 2024

Advanced Technology in Neuroscience

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Nerve injury can result in severe damage and potentially permanent disability, imposing substantial physical, psychological, and economic burdens on affected individuals and their families. Despite advances in surgical repair techniques, the functional recovery of nerves remains suboptimal. The current therapeutic approaches for nerve injury exhibit limited efficacy in restoring function, underscoring the imperative for the development of innovative treatment modalities. In recent years, bionics has emerged as a promising field in medicine, particularly in the treatment and rehabilitation of nerve injuries. We review the advances in the application of bionic technology within the realm of nerve injury treatment, encompassing bionic nerve scaffolds, nerve regeneration materials, and nerve modulation techniques. We delve into how these technologies may facilitate the repair and functional restoration of nerve tissues, as well as the challenges they encounter in clinical translation and their prospective directions for future development. Furthermore, we explore the convergence of bionic technology with existing therapeutic strategies and discuss the potential for interdisciplinary collaboration to catalyze innovation in nerve injury treatment. The integration of bionics with conventional methods may offer a synergistic approach, enhancing the efficacy of nerve repair and rehabilitation processes.

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Advances, challenges, and future directions in the clinical translation of ECM biomaterials for regenerative medicine applications

Cited by 2 publications

References 210 publications

Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect

Pericardial bioscaffold coated with ECM gels and urothelial cells for the repair of a rabbit urinary bladder defect

Application and progress of bionic scaffolds in nerve repair: a narrative review

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