Advances in adult asthma diagnosis and treatment in 2012: Potential therapeutics and gene-environment interactions

Apter, Andrea J.

doi:10.1016/j.jaci.2012.11.020

Cited by 16 publications

(16 citation statements)

References 72 publications

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“…2). Collectively, although our results do not rule out alterations in the microbioata composition in the Gnas ΔCD11c mice, these findings argue for gene-environment interactions other than with the microbiome as the main drivers of the Th2 bias and the development of Th2-mediated murine asthma (42).…”

Section: Discussioncontrasting

confidence: 85%

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

Lee¹,

Kim

Murray

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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The inductive role of dendritic cells (DC) in Th2 differentiation has not been fully defined. We addressed this gap in knowledge by focusing on signaling events mediated by the heterotrimeric GTP binding proteins Gαs, and Gαi, which respectively stimulate and inhibit the activation of adenylyl cyclases and the synthesis of cAMP. We show here that deletion of Gnas, the gene that encodes Gαs in mouse CD11c + cells (Gnas ΔCD11c mice), and the accompanying decrease in cAMP provoke Th2 polarization and yields a prominent allergic phenotype, whereas increases in cAMP inhibit these responses. The effects of cAMP on DC can be demonstrated in vitro and in vivo and are mediated via PKA. Certain gene products made by Gnas ΔCD11c DC affect the Th2 bias. These findings imply that G protein-coupled receptors, the physiological regulators of Gαs and Gαi activation and cAMP formation, act via PKA to regulate Th bias in DC and in turn, Th2-mediated immunopathologies.cAMP | dendritic cells | Th2 | PKA | asthma

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Section: Discussioncontrasting

confidence: 85%

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

Lee¹,

Kim

Murray

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…30 Advances in adult asthma diagnosis and treatment in 2012 was reviewed, stating their potential therapeutics and gene–environment interactions. 31 There was also debate on the effect of the environment on an individual's health from pollution, climate change, and epigenetic influences. These data underlined the importance of understanding gene–environment interactions in the pathogenesis of asthma and response to treatment.…”

Section: Genetics Of Asthma and Rhinosinusitismentioning

confidence: 99%

“…These data underlined the importance of understanding gene–environment interactions in the pathogenesis of asthma and response to treatment. 31 …”

Section: Genetics Of Asthma and Rhinosinusitismentioning

confidence: 99%

Asthma Linked with Rhinosinusitis: An Extensive Review

Frieri

2014

Allergy�Rhinol (Providence)

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“…Last year’s “Advances in Pediatric Asthma in 2012: Moving toward asthma prevention” included a discussion of new tools to predict the risks for asthma, steps to prevent asthma exacerbations, and possible methods to prevent the evolution of severe asthma (1). Also last year’s review by Andrea Apter on adult asthma focused on new developments in medications as well as gene-environment interactions (2). …”

Section: Introductionmentioning

confidence: 99%

Advances in pediatric asthma in 2013: Coordinating asthma care

Szefler

2014

Journal of Allergy and Clinical Immunology

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Last year’s Advances in Pediatric Asthma: Moving Toward Asthma Prevention concluded that: “We are well on our way to creating a pathway around wellness in asthma care and also to utilize new tools to predict the risk for asthma and take steps to not only prevent asthma exacerbations but also to prevent the early manifestations of the disease and thus prevent its evolution to severe asthma.” This year’s summary will focus on recent advances in pediatric asthma on pre- and postnatal factors altering the natural history of asthma, assessment of asthma control, and new insights regarding potential therapeutic targets for altering the course of asthma in children as indicated in Journal of Allergy and Clinical Immunology publications in 2013 and early 2014. Recent reports continue to shed light on methods to understand factors that influence the course of asthma, methods to assess and communicate levels of control, and new targets for intervention as well as new immunomodulators. It will now be important to carefully assess risk factors for the development of asthma as well as the risk for asthma exacerbations and to improve the way we communicate this information in the health care system. This will allow parents, primary care physicians, specialists and provider systems to more effectively intervene in altering the course of asthma and to further reduce asthma morbidity and mortality.

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Advances in adult asthma diagnosis and treatment in 2012: Potential therapeutics and gene-environment interactions

Cited by 16 publications

References 72 publications

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

Asthma Linked with Rhinosinusitis: An Extensive Review

Advances in pediatric asthma in 2013: Coordinating asthma care

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