Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering

He, Qing; Tong, Tianjian; Yu, Chenxu; Wang, Qun

doi:10.3390/md21010014

Cited by 17 publications

(13 citation statements)

References 89 publications

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“…Wang et al developed calcium alginate-based hydrogel, which promoted a wound healing rate above 96%. Moreover, alginate hydrogels do not adhere to the wound site and can be easily removed without secondary damage [46,56].…”

Section: Discussionmentioning

confidence: 99%

Scientometric Research on Trend Analysis of Nano-Based Sustained Drug Release Systems for Wound Healing

Tang

Cai

et al. 2023

Pharmaceutics

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Nanomaterials, such as the nanoparticle (NP), nanomicelle, nanoscaffold, and nano-hydrogel, have been researched as nanocarriers for drug delivery more and more recently. Nano-based drug sustained release systems (NDSRSs) have been used in many medical fields, especially wound healing. However, as we know, no scientometric analysis has been seen on applying NDSRSs in wound healing, which could be of great importance to the relevant researchers. This study collected publications from 1999 to 2022 related to NDSRSs in wound healing from the Web of Science Core Collection (WOSCC) database. We employed scientometric methods to comprehensively analyze the dataset from different perspectives using CiteSpace, VOSviewer, and Bibliometrix. The results indicated that China published the most significant number of documents in the last two decades, Islamic Azad Univ was the most productive institution, and Jayakumar, R was the most influential author. Regarding the analysis of keywords, trend topics indicate that “antibacterial”, “chitosan (CS)”, “scaffold”, “hydrogel”, “silver nanoparticle”, and “growth factors (GFs)” are the hot topics in recent years. We anticipate that our work will provide a comprehensive overview of research in this field and help scholars better understand the research hotspots and frontiers in this area, thus inspiring further explorations in the future.

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Section: Discussionmentioning

confidence: 99%

Scientometric Research on Trend Analysis of Nano-Based Sustained Drug Release Systems for Wound Healing

Tang

Cai

et al. 2023

Pharmaceutics

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“…Researchers have been looking for materials with improved bone tissue scaffolding properties, and alginate is one of the most common materials used to make bioinks (Mrudulakumari Vasudevan et al, 2021). Due to its chemical inertness and superior gel properties, alginate can form bone tissue engineering scaffolds with more stability and optimized mechanical properties (He et al, 2022).…”

Section: Research Statusmentioning

confidence: 99%

Bibliometric and visualized analysis of 3D printing bioink in bone tissue engineering

Wang

et al. 2023

Front. Bioeng. Biotechnol.

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Background: Applying 3D printed bioink to bone tissue engineering is an emerging technology for restoring bone tissue defects. This study aims to evaluate the application of 3D printing bioink in bone tissue engineering from 2010 to 2022 through bibliometric analysis, and to predict the hotspots and developing trends in this field.Methods: We retrieved publications from Web of Science from 2010 to 2022 on 8 January 2023. We examined the retrieved data using the bibliometrix package in R software, and VOSviewer and CiteSpace were used for visualizing the trends and hotspots of research on 3D printing bioink in bone tissue engineering.Results: We identified 682 articles and review articles in this field from 2010 to 2022. The journal Biomaterials ranked first in the number of articles published in this field. In 2016, an article published by Hölzl, K in the Biofabrication journal ranked first in number of citations. China ranked first in number of articles published and in single country publications (SCP), while America surpassed China to rank first in multiple country publications (MCP). In addition, a collaboration network analysis showed tight collaborations among China, America, South Korea, Netherlands, and other countries, with the top 10 major research affiliations mostly from these countries. The top 10 high-frequency words in this field are consistent with the field’s research hotspots. The evolution trend of the discipline indicates that most citations come from Physics/Materials/Chemistry journals. Factorial analysis plays an intuitive role in determining research hotspots in this sphere. Keyword burst detection shows that chitosan and endothelial cells are emerging research hotspots in this field.Conclusion: This bibliometric study maps out a fundamental knowledge structure including countries, affiliations, authors, journals and keywords in this field of research from 2010 to 2022. This study fills a gap in the field of bibliometrics and provides a comprehensive perspective with broad prospects for this burgeoning research area.

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“…The formation of alginate gels can be achieved by ionic bonding with cations or acid deposition [ 65 ]. In other medical applications, alginate is used in fibrous gels (surgical threads), alginate salts (wound dressings), drug delivery, and tissue engineering [ 66 ]. Islet transplantation is an effective therapeutic modality to stabilize glycemic control in type 1 diabetes patients [ 67 ].…”

Section: Hydrogel and Artificial Cell Sheetsmentioning

confidence: 99%

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

Miyamoto

2023

Gels

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Organ transplantation is the first and most effective treatment for missing or damaged tissues or organs. However, there is a need to establish an alternative treatment method for organ transplantation due to the shortage of donors and viral infections. Rheinwald and Green et al. established epidermal cell culture technology and successfully transplanted human-cultured skin into severely diseased patients. Eventually, artificial cell sheets of cultured skin were created, targeting various tissues and organs, including epithelial sheets, chondrocyte sheets, and myoblast cell sheets. These sheets have been successfully used for clinical applications. Extracellular matrix hydrogels (collagen, elastin, fibronectin, and laminin), thermoresponsive polymers, and vitrified hydrogel membranes have been used as scaffold materials to prepare cell sheets. Collagen is a major structural component of basement membranes and tissue scaffold proteins. Collagen hydrogel membranes (collagen vitrigel), created from collagen hydrogels through a vitrification process, are composed of high-density collagen fibers and are expected to be used as carriers for transplantation. In this review, the essential technologies for cell sheet implantation are described, including cell sheets, vitrified hydrogel membranes, and their cryopreservation applications in regenerative medicine.

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Advances in Algin and Alginate-Hybrid Materials for Drug Delivery and Tissue Engineering

Cited by 17 publications

References 89 publications

Scientometric Research on Trend Analysis of Nano-Based Sustained Drug Release Systems for Wound Healing

Scientometric Research on Trend Analysis of Nano-Based Sustained Drug Release Systems for Wound Healing

Bibliometric and visualized analysis of 3D printing bioink in bone tissue engineering

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

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