Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides

Yao, Wanzi; Qiu, Hua-Mai; Cheong, Kit-Leong; Zhong, Saiyi

doi:10.1016/j.ijbiomac.2022.09.055

Cited by 80 publications

(36 citation statements)

References 146 publications

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“…These alternative suspending agents should also be inexpensive which will in effect lower the total cost incurred in the production of the suspension. They should also be nontoxic and moreover not pose any irritations [9][10][11][12]. This study therefore seeks to evaluate the suspending properties of pectin from watermelon rind.…”

Section: Introductionmentioning

confidence: 99%

Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms

Owusu

Boakye-Gyasi

Bayor

et al. 2022

BioMed Research International

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Pectin is a high molecular weight polymer which is present in virtually all plants where it contributes to the cell structure. Pectin is a high valuable food ingredient widely used as a gelling agent and thickening agent with limited use in the pharmaceutical industry. The objective of this study is to evaluate the suspending properties of pectin from watermelon rind. Tragacanth was used as a standard suspending agent to which the suspending properties of pectin from watermelon rinds were compared with. The extracted pectin was subjected to phytochemical and physiochemical characterization for its safety and suitability to use as a suspending agent. Paracetamol suspensions were formulated using tragacanth concentrations of 0.5% w/v, 1% w/v, and 2% w/v and compared with paracetamol suspensions containing the same concentrations of watermelon pectin. The suspensions were all tested for their pH, sedimentation rate, sedimentation volume, flow rate, and ease of redispersibility over a period of 4 weeks. At the end of the 4-week period, all formulated suspensions had no changes in their pH values. Suspensions containing the extracted pectin had a lower rate of sedimentation and ease of redispersibility compared to that of tragacanth. In addition, their sedimentation volumes as well as flow rates were comparable to that of the tragacanth formulations. Ultimately, pectin from watermelon rind can serve as a suitable alternative to tragacanth in formulation of pharmaceutical suspensions.

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Section: Introductionmentioning

confidence: 99%

Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms

Owusu

Boakye-Gyasi

Bayor

et al. 2022

BioMed Research International

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“…PZMP3-1 had a linear or branched structure, and the chain of PZMP3-1 featured a helical shape. PZMP3-1 aggregation might be explained by intermolecular and intramolecular hydrogen bonding on its surface, which acted as a catalyst to produce the potent intramolecular and intermolecular connections and the interactions with the water molecule ( 56 , 57 ). Considering these morphological traits, we could conclude that the entangled and branched structure existed in PZMP3-1 molecules, which could significantly affect the bioactivity, structure, and distribution.…”

Section: Resultsmentioning

confidence: 99%

Structural characterization of a new high molecular weight polysaccharide from jujube fruit

Wang

Hao³

et al. 2022

Front. Nutr.

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From Ziziphus Jujuba cv. Muzao fruit, a new polysaccharide (PZMP3-1) with high molecular weight was isolated. Constructional characterization revealed that PZMP3-1 comprized 2.56 rhamnose, 7.70 arabinoses, 3.73 galactose, and 6.73 galactose, and it has a 241 kDa average molecular weight. The principal structural components of PZMP3-1 were 1,2,4 and 1,4-linked GalpA, 1,4-linked Galp, 1,3 and 1,5-linked Araf, and 1-linked Rhap based on methylation and nuclear magnetic resonance spectroscopy (NMR) analyses. X-ray diffraction (XRD), Fourier transforms infrared spectroscopy (FT-IR), atomic force microscopy (AFM), and scanning electron microscopy (SEM) structural analysis of PZMP3-1 revealed a tangled and branching pattern. Overall, these structural results suggested that PZMP3-1 could have unique bioactivities and be widely used in nutritional supplements.

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“…Agar is composed of agarose and agaropectin, which are normally found in Gelidium and Gracilaria spp. The former is chemically composed of 3,6-anhydro-L-galactopyranose and D-galactose, whereas the latter is composed of alternating units of L-galactose and D-galactose linked by sulfate groups [ 22 ]. Agaropectin-derived oligosaccharides from Gloiopeltis furcata showed antidiabetic effects via the regulation of mitochondrial function and increased insulin sensitivity by regulating the reactive oxygen species (ROS)-mediated IRS/AKT/GSK-3β/GS signaling pathway [ 23 ].…”

Section: Structure–function Relationship Of Maps To Cardioprotective ...mentioning

confidence: 99%

A Comprehensive Review of the Cardioprotective Effect of Marine Algae Polysaccharide on the Gut Microbiota

Cheong

Chen

et al. 2022

Foods

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Cardiovascular disease (CVD) is the number one cause of death worldwide. Recent evidence has demonstrated an association between the gut microbiota and CVD, including heart failure, cerebrovascular illness, hypertension, and stroke. Marine algal polysaccharides (MAPs) are valuable natural sources of diverse bioactive compounds. MAPs have many pharmaceutical activities, including antioxidant, anti-inflammatory, immunomodulatory, and antidiabetic effects. Most MAPs are not utilized in the upper gastrointestinal tract; however, they are fermented by intestinal flora. The relationship between MAPs and the intestinal microbiota has drawn attention in CVD research. Hence, this review highlights the main action by which MAPs are known to affect CVD by maintaining homeostasis in the gut microbiome and producing gut microbiota-generated functional metabolites and short chain fatty acids. In addition, the effects of trimethylamine N-oxide on the gut microbiota composition, bile acid signaling properties, and CVD prevention are also discussed. This review supports the idea that focusing on the interactions between the host and gut microbiota may be promising for the prevention or treatment of CVD. MAPs are a potential sustainable source for the production of functional foods or nutraceutical products for preventing or treating CVD.

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Advances in anti-cancer effects and underlying mechanisms of marine algae polysaccharides

Cited by 80 publications

References 146 publications

Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms

Pharmaceutical Assessment of Watermelon Rind Pectin as a Suspending Agent in Oral Liquid Dosage Forms

Structural characterization of a new high molecular weight polysaccharide from jujube fruit

A Comprehensive Review of the Cardioprotective Effect of Marine Algae Polysaccharide on the Gut Microbiota

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