Advances in aptamer-based drug delivery vehicles for cancer therapy

Ghasemii, Kousar; Darroudi, Mahdieh; Rahimmanesh, Ilnaz; Ghomi, Matineh; Hassanpour, Mahnaz; Sharifi, Esmaeel; Yousefiasl, Satar; Ahmadi, Sepideh; Zarrabi, Ali; Borzacchiello, Assunta; Rabiee, Mohammad; Paiva‐Santos, Ana Cláudia; Rabiee, Navid

doi:10.1016/j.bioadv.2022.213077

Cited by 22 publications

(8 citation statements)

References 98 publications

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“…Many investigations have been conducted on the development of complexes using the EpCAM aptamer. In vitro experiments showed that aptamer-conjugated NPs were taken up more readily by tumor cells expressing EpCAM than unconjugated NPs in EpCAM-expressing cell lines [ 142 ].…”

Section: Dna-based Materialsmentioning

confidence: 99%

“…Liet et al developed a complex of EpCAM aptamer-conjugated PLGA nanoparticles encapsulated with curcumin. Since free curcumin was toxic to both HT29 cells and nontarget HEK293T cells, this complex was significantly more effective against EpCAM-expressing HT29 cells [ 142 ].…”

Section: Dna-based Materialsmentioning

confidence: 99%

“…For targeted delivery of DOX to colon cancer cells, complexes were constructed in which the EpCAM aptamer was conjugated with DOX-loaded mesoporous silica nanoparticles. The results of this study showed that cellular uptake and cytotoxicity in SW620 cells were significantly higher in the complex where the aptamer was present, and this complex significantly inhibited EpCAM expression on tumor cells [ 142 ].…”

Section: Dna-based Materialsmentioning

confidence: 99%

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DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors

Shishparenok

Furman

Zhdanov

2023

Cancers

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DNA nanotechnology has significantly advanced and might be used in biomedical applications, drug delivery, and cancer treatment during the past few decades. DNA nanomaterials are widely used in biomedical research involving biosensing, bioimaging, and drug delivery since they are remarkably addressable and biocompatible. Gradually, modified nucleic acids have begun to be employed to construct multifunctional DNA nanostructures with a variety of architectural designs. Aptamers are single-stranded nucleic acids (both DNAs and RNAs) capable of self-pairing to acquire secondary structure and of specifically binding with the target. Diagnosis and tumor therapy are prospective fields in which aptamers can be applied. Many DNA nanomaterials with three-dimensional structures have been studied as drug delivery systems for different anticancer medications or gene therapy agents. Different chemical alterations can be employed to construct a wide range of modified DNA nanostructures. Chemically altered DNA-based nanomaterials are useful for drug delivery because of their improved stability and inclusion of functional groups. In this work, the most common oligonucleotide nanomaterials were reviewed as modern drug delivery systems in tumor cells.

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Section: Dna-based Materialsmentioning

confidence: 99%

Section: Dna-based Materialsmentioning

confidence: 99%

Section: Dna-based Materialsmentioning

confidence: 99%

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DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors

Shishparenok

Furman

Zhdanov

2023

Cancers

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“…Moreover, molecular targets that are hard to generate antibody for can also be targeted by aptamers [ 27 ]. These advantages have led to the rapid development of aptamer-based therapeutics in recent years [ 28 ]. Aptamers against EpCAM, CD44, and CD133 have been used widely as targeting ligands to guide therapeutic agents to CSCs in different tumor types [ [29] , [30] , [31] ].…”

Section: Introductionmentioning

confidence: 99%

Recent advances in aptamer-based therapeutic strategies for targeting cancer stem cells

Liu¹,

Hu²,

Xiang³

et al. 2023

Materials Today Bio

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“…Researchers are continuously working to improve the stability, specificity, and delivery of aptamer-based theranostics. Novel aptamer conjugation techniques, such as click chemistry, have been developed to improve the stability and efficacy of aptamer–drug conjugates [ 9 ]. Additionally, new delivery systems, such as exosomes and cell-penetrating peptides, are being explored to improve the delivery of aptamer-based formulations.…”

mentioning

confidence: 99%