Advances in assessment of pain behaviors and mechanisms of post-operative pain models

Segelcke, Daniel; Pradier, Bruno; Pogatzki-Zahn, Esther

doi:10.1016/j.cophys.2019.07.002

Cited by 30 publications

(43 citation statements)

References 83 publications

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“…We performed proteomic analysis at POD 1 after INC because at this time point, pain-associated behaviors are fully established in the mouse incision model, translating well to pain in patients 1 day after surgery. 6 , 55 , 64 By unbiased proteome profiling, we identified 44 INC-regulated candidate proteins. This relatively low number of modulated proteins in DRG after INC contrasts the 715 regulated proteins identified in our previous data set on neuropathic pain after spared-nerve injury (SNI).…”

Section: Discussionmentioning

confidence: 99%

“… 54 Incision injury, as a surrogate for postoperative pain, is known to induce the activation of diverse nociceptive signaling pathways and inflammatory responses in peripheral tissues and dorsal root ganglia (DRG) innervating the injured region. 55 , 64 In particular, alterations of proteins involved in aforementioned processes may drive activity-dependent plasticity, alter the excitability in peripheral nociceptors and, consequently, in the central nervous system. 64 These changes are distinct to those after other types of tissue injuries and contribute to pain-related behaviors after incision.…”

Section: Introductionmentioning

confidence: 99%

“… 55 , 64 In particular, alterations of proteins involved in aforementioned processes may drive activity-dependent plasticity, alter the excitability in peripheral nociceptors and, consequently, in the central nervous system. 64 These changes are distinct to those after other types of tissue injuries and contribute to pain-related behaviors after incision. 15 , 54 However, our knowledge of the mechanistic underpinnings, specific cellular protein networks, and possible interactions within major signaling pathways governing these changes in DRG after incision injury is still very limited.…”

Section: Introductionmentioning

confidence: 99%

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A proteome signature for acute incisional pain in dorsal root ganglia of mice

Pogatzki-Zahn

Gómez-Varela

Erdmann³

et al. 2021

Pain

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A proteome signature for acute incisional pain in dorsal root ganglia of mice

Pogatzki-Zahn

Gómez-Varela

Erdmann³

et al. 2021

Pain

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“…Pain is the main factor that triggers changes in the neurobiology of stress after surgery since it is responsible for the neuronal and biochemical feedback through mediators such as substance P, bradykinin, histamine, glutamate, potassium ions, and the calcitonin gene-related peptide [11]. These substances, known together as the "inflammatory soup," have been associated with pain or stress in animals, where studies have recognized alterations that can affect the state of alertness and performance of learning and memory [83].…”

Section: Behavioral Changes Associated With a Predominance Of Sympathetic Tone That Indicates Hemodynamic Reactivity Due To Pain And Surgmentioning

confidence: 99%

Neurobiology of anesthetic-surgical stress and induced behavioral changes in dogs and cats: A review

et al. 2021

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The anesthetic-surgical stress response consists of metabolic, neuroendocrine, hemodynamic, immunological, and behavioral adaptations through chemical mediators such as the adrenocorticotropic hormone, growth hormone, antidiuretic hormone, cortisol, aldosterone, angiotensin II, thyroid-stimulating hormone, thyroxine, triiodothyronine, follicle-stimulating hormone, luteinizing hormone, catecholamines, insulin, interleukin (IL)-1, IL-6, tumor necrosis factor-alpha, and prostaglandin E-2. Behavioral changes include adopting the so-called prayer posture, altered facial expressions, hyporexia or anorexia, drowsiness, sleep disorders, restriction of movement, licking or biting the injured area, and vocalizations. Overall, these changes are essential mechanisms to counteract harmful stimuli. However, if uncontrolled surgical stress persists, recovery time may be prolonged, along with increased susceptibility to infections in the post-operative period. This review discusses the neurobiology and most relevant organic responses to pain and anesthetic-surgical stress in dogs and cats. It highlights the role of stress biomarkers and their influence on autonomous and demeanor aspects and emphasizes the importance of understanding and correlating all factors to provide a more accurate assessment of pain and animal welfare in dogs and cats throughout the surgical process.

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“…Regardless of the age of the patient, postoperative pain is a relevant topic (Walker, 2015), especially in relation to the unique entity of this injury (Pogatzki-Zahn et al, 2017;Pogatzki-Zahn, Segelcke, & Zahn, 2018;Segelcke, Pradier, & Pogatzki-Zahn, 2019) and the relevance of acute postoperative pain which may prolonged chronic pain in children (Rabbitts et al, 2017(Rabbitts et al, , 2015.…”

Section: Developmental Changes Of Spinal Cox Isoenzymes For Pain Behaviour After Incisionmentioning

confidence: 99%

The role of the spinal cyclooxygenase (COX) for incisional pain in rats at different developmental stages

Segelcke

Reichl

Neuffer

et al. 2019

European Journal of Pain

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Background Cyclooxygenase enzymes (COX)‐1 and COX‐2 are important targets for pain relief after surgery, but the spinal contribution of both isoforms is still unclear, e.g., from a developmental point of view. Here, we studied changes of spinal COX‐1 and COX‐2 expression and their functional relevance in rats of different ages for pain‐related behaviour after incision. Methods Mechanical paw withdrawal thresholds (PWT) were assessed before and after incision and after intrathecal administration (IT) of SC‐560 (COX‐1 inhibitor) or NS‐398 (COX‐2 inhibitor) in rats aged 5, 14 and 28 days (P5, P14, P28). Furthermore, spinal expressions of COX m‐RNA and proteins were investigated. Results In P5 rats, only IT‐administered NS‐398 but not SC‐560 significantly reversed the decreased PWT after incision. In P14 rats, none of the substance modified PWT, and in P28 rats, only SC‐560 increased PWT. Spinal COX‐2 mRNA and protein were increased in P5 but not in P14 and P28 rats after incision. Whereas COX‐2 is located in spinal neurons, COX‐1 is mainly found in spinal microglia cells. Conclusion Our results demonstrate a possible developmental transition from COX‐2 to COX‐1 activation. Whereas in adult rats spinal COX‐1 but not COX‐2 is involved in pain‐related behaviour after incision, it seems opposite in P5 rats. Interestingly, in P14, neither COX‐1 nor COX‐2 seems to play a role. This switch may relate to altered neuronal/microglia activation. Our findings indicate specific mechanisms to pain after incision that are age‐dependent and may guide further research improving paediatric pain management. Significance Postoperative pain in pediatric patients after surgery is still poorly controlled; this might contribute to long‐lasting alteration in the nociceptive system and prolonged chronic pain. Here we show a possible developmental switch in the COX‐dependent pathway for nociceptive spinal transmission that may explain why pain management in young children needs to be related to age‐dependent mechanisms.

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Advances in assessment of pain behaviors and mechanisms of post-operative pain models

Cited by 30 publications

References 83 publications

A proteome signature for acute incisional pain in dorsal root ganglia of mice

A proteome signature for acute incisional pain in dorsal root ganglia of mice

Neurobiology of anesthetic-surgical stress and induced behavioral changes in dogs and cats: A review

The role of the spinal cyclooxygenase (COX) for incisional pain in rats at different developmental stages

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