Advances in asthma, asthma-COPD overlap, and related biologics in 2018

Bacharier, Leonard B.; Mori, Akio; Kita, Hirohito

doi:10.1016/j.jaci.2019.08.021

Cited by 12 publications

(3 citation statements)

References 114 publications

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“…Patients with chronic obstructive pulmonary disease (COPD), comorbid with asthma (asthma-COPD overlap, ACO) or bronchiectasis (bronchiectasis-COPD overlap, BCO) as well as their coexistence (ABCO), are commonly seen phenotypes, which have been broadly discussed whether they were distinct disease entities, but there is no concluded consensus yet (1). The concept of "ACO" or "asthma + COPD" appeals as a great interest to investigators (2)(3)(4)(5)(6)(7)(8)(9)(10)(11), and similar discussion applies to the research of bronchiectasis and COPD overlap (12)(13)(14)(15)(16). Few data was reported on the ABCO phenotype.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Short-Term Prognoses Within Hospitalized Chronic Obstructive Pulmonary Disease Patients Comorbid With Asthma, Bronchiectasis, and Their Overlaps: Findings From the ACURE Registry

Lei

Yang

Liang³

et al. 2022

Front. Med.

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IntroductionReal-world evidence and comparison among commonly seen chronic obstructive pulmonary disease (COPD) phenotypes, i.e., asthma–COPD overlap (ACO), bronchiectasis–COPD overlap (BCO), and their coexistence (ABCO) have not been fully depicted, especially in Chinese patients.MethodsData were retrieved from an ongoing nationwide registry in hospitalized patients due to acute exacerbation of COPD in China (ACURE).ResultsOf the eligible 4,813 patients with COPD, 338 (7.02%), 492 (10.22%), and 63 (1.31%) were identified as ACO, BCO, and ABCO phenotypes, respectively. Relatively, the ABCO phenotype had a younger age with a median of 62.99 years [interquartile range (IQR): 55.93–69.48] and the COPD phenotype had an older age with a median of 70.15 years (IQR: 64.37–76.82). The BCO and COPD phenotypes were similar in body mass index with a median of 21.79 kg/m2 (IQR: 19.47–23.97) and 21.79 kg/m2 (IQR: 19.49–24.22), respectively. The COPD phenotype had more male gender (79.90%) and smokers (71.12%) with a longer history of smoking (median: 32.45 years, IQR: 0.00–43.91). The ACO and ABCO phenotypes suffered more prior allergic episodes with a proportion of 18.05 and 19.05%, respectively. The ACO phenotype exhibited a higher level of eosinophil and better lung reversibility. Moreover, the four phenotypes showed no significant difference neither in all-cause mortality, intensive care unit admission, length of hospital stay, and COPD Assessment Test score change during the index hospitalization, and nor in the day 30 outcomes, i.e., all-cause mortality, recurrence of exacerbation, all-cause, and exacerbation-related readmission.ConclusionsThe ACO, BCO, ABCO, and COPD phenotypes exhibited distinct clinical features but had no varied short-term prognoses. Further validation in a larger sample is warranted.

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Section: Introductionmentioning

confidence: 99%

Comparison of Clinical Characteristics and Short-Term Prognoses Within Hospitalized Chronic Obstructive Pulmonary Disease Patients Comorbid With Asthma, Bronchiectasis, and Their Overlaps: Findings From the ACURE Registry

Lei

Yang

Liang³

et al. 2022

Front. Med.

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“…This has led to the term asthma-COPD overlap (ACO) syndrome. [1][2][3][4] Chronic asthma, especially in the elderly, may be associated with irreversible airflow obstruction despite maximal therapy. In COPD, patients may demonstrate reversible airflow obstruction from therapy and have peripheral blood and/or sputum eosinophilia.…”

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confidence: 99%

“…In COPD, patients may demonstrate reversible airflow obstruction from therapy and have peripheral blood and/or sputum eosinophilia. [1][2][3][4] Currently, it is estimated that the prevalence of ACO syndrome ranges from 3.8% to 31% of patients with airflow limitation depending on case definitions. 1 T H 2 responses and peripheral blood eosinophil counts typically decline with aging; however, tobacco smoking can attenuate decreases in total serum IgE levels and eosinophilic inflammation in populations with and without asthma as well.…”

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confidence: 99%