Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management

Miller, Rachel L.; Grayson, Mitchell H.; Strothman, Kasey

doi:10.1016/j.jaci.2021.10.001

Cited by 137 publications

(61 citation statements)

References 81 publications

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“…Asthma is a common chronic and stubborn respiratory disease, clinically presenting with cough, chest tightness, wheezing, and shortness of breath ( Papi et al, 2018 ). Non-timely treatment will lead to a series of secondary diseases, such as chronic obstructive pulmonary disease and heart failure, which can become life-threatening ( Schoettler and Strek, 2020 ; Miller et al, 2021 ). At the same time, it also added a serious financial burden to the family ( López-Tiro et al, 2022 ).…”

Section: Pharmacological Activitiesmentioning

confidence: 99%

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Wang

et al. 2022

Front. Pharmacol.

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Asparagus cochinchinensis (Lour.) Merr. (A. cochinchinensis) is a traditional herbal medicine that is used to treat constipation, fever, pneumonia, stomachache, tracheitis, rhinitis, cataract, acne, urticaria. More than 90 compounds have been identified from different structural types in A. cochinchinensis, including steroidal saponins, C21-steroides, lignans, polysaccharides, amino acids, etc. These bioactive ingredients make A. cochinchinensis remarkable for its pharmacological effects on anti-asthma, anti-inflammatory, anti-oxidation, anti-tumor, improving Alzheimer’s disease, neuroprotection, gut health-promoting and so on. Moreover, A. cochinchinensis also plays an important role in food, health product, cosmetic, and other fields. This review focused on the research publications of A. cochinchinensis and aimed to summarize the advances in the botany, traditional uses, phytochemistry, pharmacology, and applications which will provide reference for the further studies and applications of A. cochinchinensis.

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Section: Pharmacological Activitiesmentioning

confidence: 99%

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Wang

et al. 2022

Front. Pharmacol.

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“…The cardiac remodeling process is a common mechanism for the progression of heart failure [37]. Finally, obesity has been reported to play a role in both asthma and heart failure [38][39][40]. Evidence suggests that obesity is a state of low-grade inflammation, which releases cytokines that are associated with both asthma and cardiovascular diseases [41,42].…”

Section: Plos Onementioning

confidence: 99%

The causal relationship between allergic diseases and heart failure: Evidence from Mendelian randomization study

2022

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Background Emerging evidence shows allergic diseases, such as atopic dermatitis and asthma, are risk factors of heart failure. However, the causal relationship between allergic diseases and heart failure is not clear. Methods We performed a two-sample Mendelian randomization analysis between allergic diseases and heart failure using summary statistics of genome-wide association studies from large GWAS consortia, with total sample size of 1.2 million. Independent instrumental variables for asthma and atopic dermatitis (P<1×10−5) were used as the exposure. We applied five models for the Mendelian randomization analysis. Finally, we performed the sensitivity analyses to assess the robustness of the results. Results We have identified 55 independent single nucleotide polymorphisms (SNPs) for asthma 54 independent SNPs for atopic dermatitis as our instrumental variables. The inverse variance-weighted (IVW) analysis showed asthma was significantly associated with increased risk of heart failure (ORIVW = 1.04, 95% CI, 1.01–1.07, P = 0.03). The Mendelian randomization analysis using the other four models also showed consistent results with the IVW analysis. Similarly, atopic dermatitis was also significantly associated with an increased risk of heart failure (ORIVW = 1.03, 95% CI, 1.01–1.06, P = 0.01), consistent with the other four models. The sensitivity analysis showed no evidence of horizontal pleiotropy or results were driven by single SNPs. Conclusion Our study identified asthma and atopic dermatitis as a causal risk factor for heart failure and suggest inflammatory pathogenesis as a key factor contributing to the underlying mechanism. These findings emphasize the importance of asthma and allergy control in the prevention and management of heart failure.

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“…Asthma is a chronic obstructive inflammatory airway disease that often develops early in life [1,2], and affects around 10-15% of school children [3,4]. Childhood asthma is complex and heterogeneous, characterized by reversible airflow obstruction and inflammation triggered by allergens, environmental pollutants and infections [3,5]. The treatment often consist of inhaled bronchodilators for symptom relief, anti-inflammatory drugs such as corticosteroids [3,6] and in serious disease the addition of immunomodulatory medication for control [7,8].…”

Section: Introductionmentioning

confidence: 99%

Skin Barrier Function and Infant Tidal Flow-Volume Loops—A Population-Based Observational Study

et al. 2022

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Background: The relationship between skin barrier- and lung function in infancy is largely unexplored. We aimed to explore if reduced skin barrier function by high transepidermal water loss (TEWL), or manifestations of eczema or Filaggrin (FLG) mutations, were associated with lower lung function in three-month-old infants. Methods: From the population-based PreventADALL cohort, 899 infants with lung function measurements and information on either TEWL, eczema at three months of age and/or FLG mutations were included. Lower lung function by tidal flow-volume loops was defined as the ratio of time to peak tidal expiratory flow to expiratory time (tPTEF/tE) <0.25 and a tPTEF <0.17 s (<25th percentile). A high TEWL >8.83 g/m2/h (>75th percentile) denoted reduced skin barrier function, and DNA was genotyped for FLG mutations (R501X, 2282del4 and R2447X). Results: Neither a high TEWL, nor eczema or FLG mutations, were associated with lower tPTEF/tE. While a high TEWL was associated with a lower tPTEF; adjusted OR (95% CI) 1.61 (1.08, 2.42), the presence of eczema or FLG mutations were not. Conclusions: Overall, a high TEWL, eczema or FLG mutations were not associated with lower lung function in healthy three-month-old infants. However, an inverse association between high TEWL and tPTEF was observed, indicating a possible link between the skin barrier- and lung function in early infancy.

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Advances in asthma: New understandings of asthma’s natural history, risk factors, underlying mechanisms, and clinical management

Cited by 137 publications

References 81 publications

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

Asparagus cochinchinensis: A review of its botany, traditional uses, phytochemistry, pharmacology, and applications

The causal relationship between allergic diseases and heart failure: Evidence from Mendelian randomization study

Skin Barrier Function and Infant Tidal Flow-Volume Loops—A Population-Based Observational Study

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