Advances in auditory and vestibular medicine

Hamid, Mohamed A.; Trune, Dennis R.; Dutia, Mayank B.

doi:10.3109/02841860903364076

Cited by 7 publications

(7 citation statements)

References 63 publications

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“…Subsequent clinical studies have demonstrated that steroids can be used for the treatment of specific vestibular pathologies in both males and females. In detail, intratympanic steroids perfusion was found to be very effective against the Meniere’s syndrome (40,41). It has also been demonstrated that stress steroids affect specific vestibular functions such as synaptic or neuronal plasticity related to the phenomenon of ‘vestibular compensation’ and behavioral recovery after unilateral vestibular damage (42,43).…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localisation and Molecular Expression of the Steroidogenic Enzyme Cytochrome P450 17α-Hydroxylase /C(17,20)-Lyase in the Vestibular Nuclei of Adult Male Rats

Manca

Mulliri

Burrai

et al. 2011

Journal of Neuroendocrinology

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Many biologically active neurosteroids, including dehydroepiandrosterone (DHEA), are synthesised in the brain. DHEA is a potent endogenous modulator of several neuronal functions, and alterations of DHEA are correlated with various neurobiological deficits. The cytochrome P450 17α-hydroxylase/C(17,20)-lyase (P450C(17) ) plays a pivotal role in the synthesis of DHEA from pregnenolone and progesterone. We investigated the immunohistochemical localisation and molecular expression of P450C(17) in the superior, lateral, medial and inferior vestibular nuclei (VCN) of adult male rats by western blotting and indirect immunofluorescence analysis. Immunoreactive P450C(17) was widely distributed in all VCN and the expression of P450C(17) was confirmed by western blot analysis. The present study demonstrates, for the first time, the presence and anatomical distribution of P450C(17) in the VCN. Given that neurosteroids can modulate neuronal activities in the medial vestibular nucleus, DHEA synthesised in the VCN may play an important role in the control of specific activities at this level.

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Section: Discussionmentioning

confidence: 99%

Immunohistochemical Localisation and Molecular Expression of the Steroidogenic Enzyme Cytochrome P450 17α-Hydroxylase /C(17,20)-Lyase in the Vestibular Nuclei of Adult Male Rats

Manca

Mulliri

Burrai

et al. 2011

Journal of Neuroendocrinology

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“…In the periphery stress hormones also regulate the function of ion transporters and ionic homeostasis in the inner ear, while in some conditions the anti-inflammatory actions of glucocorticoids may also come into play (Hamid et al, 2009). Stress hormones may thus modulate peripheral vestibular end-organ and cochlear function through similar mechanisms of ionic homeostasis (Canlon et al, 2007; Hamid et al, 2009), and modulate central processing in the vestibular and auditory pathways (Seemungal et al, 2001; Paterson et al, 2004; Straka et al, 2005; Mazurek et al, 2010). …”

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confidence: 99%

Interactions between Stress and Vestibular Compensation – A Review

Saman¹,

Bamiou²,

Gleeson³

et al. 2012

Front. Neur.

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Elevated levels of stress and anxiety often accompany vestibular dysfunction, while conversely complaints of dizziness and loss of balance are common in patients with panic and other anxiety disorders. The interactions between stress and vestibular function have been investigated both in animal models and in clinical studies. Evidence from animal studies indicates that vestibular symptoms are effective in activating the stress axis, and that the acute stress response is important in promoting compensatory synaptic and neuronal plasticity in the vestibular system and cerebellum. The role of stress in human vestibular disorders is complex, and definitive evidence is lacking. This article reviews the evidence from animal and clinical studies with a focus on the effects of stress on the central vestibular pathways and their role in the pathogenesis and management of human vestibular disorders.

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“…Neuromodulation of the vestibular nerves in animal models also show that vestibular pathways to the hypothalamus are involved in stress responses mediated by the hypothalamic-pituitary-adrenal axis, which may well regulate function of ion transporters and ionic homeostasis of the inner ear. 29 This relationship is, however, bidirectional as more severe PTSD symptoms in US veterans were associated with worse dizziness handicap and vertigo symptom severity scores. 30 In fact, mediation analysis of UK military veterans with mTBI showed that vestibular disturbance directly and independently influenced increased severity of postconcussion symptoms (PCS), headaches, and disability, irrespective of mediating PTSD, depression, and anxiety.…”

mentioning

confidence: 99%

Dizziness Directly Influences Postconcussion Symptoms and Is Predictive of Poorer Mental Health in UK Military Personnel: A Retrospective Analysis

Denby,

Dempster,

White

et al. 2023

Journal of Head Trauma Rehabilitation

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Objective: To investigate the contribution of dizziness to postconcussion symptoms, depression, and anxiety symptoms. Setting: Mild traumatic brain injury (mTBI) service, Defence Medical Rehabilitation Centre, Stanford Hall. Participants: Two hundred eighty-three UK military personnel from the Royal Navy, Royal Airforce, Royal Marines, and British Army. Design: A retrospective analysis of data from the Ministry of Defence medical records database. Main measures: Sixteen-item Rivermead Post Concussion Symptoms Questionnaire, Generalized Anxiety Disorder 7-item scale, Patient Health Questionnaire-9, The Dizziness Handicap Inventory. Results: Injuries from sports or falls were the most common mechanism of mTBI, accounting for 23%, respectively. Chi-square analysis indicated that individuals with dizziness and postconcussion symptoms (PCS) had greater severity of PCS, depression, and anxiety than those with PCS alone. Mediation analysis showed dizziness directly and independently influenced the severity of PCS, despite the indirect effects of mediating depression and anxiety symptoms. Conclusion: Comorbid dizziness and PCS were predictive of poorer mental health compared with PCS alone. In addition, dizziness directly influenced the severity of PCS irrespective of the indirect effects of mental health symptoms. These observations suggest that treating dizziness with vestibular rehabilitation may improve PCS and mental health.

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Advances in auditory and vestibular medicine

Cited by 7 publications

References 63 publications

Immunohistochemical Localisation and Molecular Expression of the Steroidogenic Enzyme Cytochrome P450 17α-Hydroxylase /C(17,20)-Lyase in the Vestibular Nuclei of Adult Male Rats

Immunohistochemical Localisation and Molecular Expression of the Steroidogenic Enzyme Cytochrome P450 17α-Hydroxylase /C(17,20)-Lyase in the Vestibular Nuclei of Adult Male Rats

Interactions between Stress and Vestibular Compensation – A Review

Dizziness Directly Influences Postconcussion Symptoms and Is Predictive of Poorer Mental Health in UK Military Personnel: A Retrospective Analysis

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