Advances in biomaterials for the treatment of retinoblastoma

Farhat, Wissam; Yeung, Vincent; Ross, Amy E.; Kahale, Francesca; Boychev, Nikolay; Kuang, Liangju; Chen, Lin; Ciolino, Joesph

doi:10.1039/d2bm01005d

Cited by 16 publications

(6 citation statements)

References 338 publications

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“…The treatment modalities of retinoblastoma remain a complex process involving a multitude of different treatments that include a combination of chemotherapy, cryotherapy, immunotherapy, radiotherapy, and surgery, yet these are often met with severe side effects due to their non-specific targeting on healthy cells [ 55 ]. There has been great progress in creating novel methods for different therapeutic approaches, such as 3D bioprinting, hydrogels, and nanoparticles in different diseases [ 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

et al. 2022

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Chemotherapy is often used to treat retinoblastoma; however, this treatment method has severe systemic adverse effects and inadequate therapeutic effectiveness. Extracellular vesicles (EVs) are important biological information carriers that mediate local and systemic cell-to-cell communication under healthy and pathological settings. These endogenous vesicles have been identified as important drug delivery vehicles for a variety of therapeutic payloads, including doxorubicin (Dox), with significant benefits over traditional techniques. In this work, EVs were employed as natural drug delivery nanoparticles to load Dox for targeted delivery to retinoblastoma human cell lines (Y-79). Two sub-types of EVs were produced from distinct breast cancer cell lines (4T1 and SKBR3) that express a marker that selectively interacts with retinoblastoma cells and were loaded with Dox, utilizing the cells’ endogenous loading machinery. In vitro, we observed that delivering Dox with both EVs increased cytotoxicity while dramatically lowering the dosage of the drug. Dox-loaded EVs, on the other hand, inhibited cancer cell growth by activating caspase-3/7. Direct interaction of EV membrane moieties with retinoblastoma cell surface receptors resulted in an effective drug delivery to cancer cells. Our findings emphasize the intriguing potential of EVs as optimum methods for delivering Dox to retinoblastoma.

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Section: Discussionmentioning

confidence: 99%

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

et al. 2022

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“…Their inherent advantages, from stability to targeted delivery capabilities, position them as a potent tool in our arsenal against cancer, inching us closer to more tailored and effective treatment modalities. [49][50][51]…”

Section: Junfeng Wangmentioning

confidence: 99%

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Tao,

Rehman,

et al. 2024

J. Mater. Chem. B

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“…), or globe enucleation. Precise delivery of chemotherapeutic agents into the ophthalmic artery, available in the last decade, became the preferred treatment [ 55 , 56 ]. This targeted strategy has been shown to improve ocular survival and visual acuity while avoiding the severe systemic complications associated with systemic chemotherapy or the use of irradiation therapy [ 57 ].…”

Section: Neurointerventional Procedures In the Pediatric Populationmentioning

confidence: 99%

Pediatric Interventional Neuroradiology: Opportunities and Challenges

2023

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Pediatric interventional neuroradiology (PINR) is a relatively new field of diagnostic and therapeutic care in the pediatric population that has seen considerable advances in recent decades. However, it is still lagging behind adult interventional neuroradiology due to a variety of reasons, including the lack of evidence validating pediatric-specific procedures, the relative absence of pediatric-specific equipment, and the challenges in establishing and maintaining PINR competencies in a relatively small number of cases. Despite these challenges, the number and variety of PINR procedures are expanding for a variety of indications, including unique pediatric conditions, and are associated with reduced morbidity and psychological stigma. Continued technological advances, such as improved catheter and microwire designs and novel embolic agents, are also contributing to the growth of the field. This review aims to increase awareness of PINR and provide an overview of the current evidence base for minimally invasive neurological interventions in children. Important considerations, such as sedation, contrast agent use, and radiation protection, will also be discussed, taking into account the distinct characteristics of the pediatric population. The review highlights the usefulness and benefits of PINR and emphasizes the need for ongoing research and development to further advance this field.

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Advances in biomaterials for the treatment of retinoblastoma

Abstract: Retinoblastoma is the most common primary intraocular malignancy in children. Although traditional chemotherapy has shown some success in retinoblastoma management, there are several shortcomings to this approach, including inadequate pharmacokinetic...

Cited by 16 publications

References 338 publications

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

Doxorubicin-Loaded Extracellular Vesicles Enhance Tumor Cell Death in Retinoblastoma

A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Pediatric Interventional Neuroradiology: Opportunities and Challenges

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