Advances in biomedical applications of self-healing hydrogels

Abstract

Hydrogels are important biomaterials that have several applications in drug and cell delivery, tissue engineering, in three-dimensional (3D) printing, and more recently in sensing and actuating applications. With the advent...

Highly tough and rapid self-healing dual-physical crosslinking poly(DMAA-co-AM) hydrogel

“…Sodium dodecyl sulfate with the molecular weight of 288.38 g mol À1 was purchased from Shanghai Aladdin Bio-Chem Technology Co., Ltd. Inorganic clay "LAPONITE® XLG" nanoparticles, with the molecular formula of [Mg 5. 34 Li 0.66 Si 8 -O 20 (OH) 4 ]Na 0.66 , possessed the diameter and thickness of 30 and 1 nm, respectively, and were purchased from Rockwood Ltd, UK. All the other chemicals were of analytic grades and supplied by Shanghai Macklin Biochemical Co., Ltd. All the chemicals were used as received unless otherwise stated.…”

“…[27][28][29][30] Functional biomimetic self-healing hydrogels possess remarkable performance, such as fast self-healing properties and high mechanical strength and toughness, which greatly extend their service life, especially in articial e-skins, biosensing, and drug delivery. [31][32][33][34][35] Different approaches for repairing the damaged network structures of hydrogels have been explored to obtain highly self-healing hydrogels. The strategies to design self-healing hydrogels are mainly based on healing agents, dynamically reversible covalent bonds, or dynamically non-covalent bonds.…”

Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications

“…Crosslinking can signal reactive sites and incorporate signals and cues for where the gel should bond to different points in the injection site for a more adhesive fit, drug release, etc. [76]. This process can be conducted in several ways, both physical and chemical (Figure 4) [77].…”

“…Physical methods include imine bonding, motel-complexation, and disulfide bonds to create strong structures through chemical means. Physical alternatives include hydrogen bonds and host-guest interactions [76,77].…”

Aggregation-induced emission luminogen based self-healing hydrogels fluorescent sensors for α-amylase

“…To date, many self-healing hydrogels have been reported and they display remarkable applications in cell carriers, tissue engineering, drug delivery and so on. 12–14…”