Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Kang, Weiqi; Xu, Zhe; Lu, Haiying; Liu, Siwei; Li, Jianshu; Ding, Chunmei; Lu, Yongping

doi:10.1039/d4tb00565a

Cited by 5 publications

References 113 publications

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Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Cai,

Qiu,

Chi‐Shing Cho

et al. 2024

MedComm

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Small molecule drugs are increasingly emerging as innovative and effective treatments for various diseases, with mRNA therapeutics being a notable representative. The success of COVID‐19 vaccines has underscored the transformative potential of mRNA in RNA therapeutics. Within the RNA family, there is another unique type known as circRNA. This single‐stranded closed‐loop RNA molecule offers notable advantages over mRNA, including enhanced stability and prolonged protein expression, which may significantly impact therapeutic strategies. Furthermore, circRNA plays a pivotal role in the pathogenesis of various diseases, such as cancers, autoimmune disorders, and cardiovascular diseases, making it a promising clinical intervention target. Despite these benefits, the application of circRNA in clinical settings remains underexplored. This review provides a comprehensive overview of the current state of synthetic circRNA therapeutics, focusing on its synthesis, optimization, delivery, and diverse applications. It also addresses the challenges impeding the advancement of circRNA therapeutics from bench to bedside. By summarizing these aspects, the review aims to equip researchers with insights into the ongoing developments and future directions in circRNA therapeutics. Highlighting both the progress and the existing gaps in circRNA research, this review offers valuable perspectives for advancing the field and guiding future investigations.

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Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Cai,

Qiu,

Chi‐Shing Cho

et al. 2024

MedComm

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Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications

Rodriguez,

Shukla,

Mukhanova

et al. 2024

Preprint

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Calcium phosphate (CaP) polymorphs are non-toxic and biocompatible, making them intriguing for a variety of applications, including hard tissue regeneration, medicine delivery, and vaccine development. Investigating the mechanism of calcium phosphate nucleation and development is critical for understanding disorders caused by pathological mineralization and developing biomimetic materials with suitable properties. The current CaP in situ/batch biomineralization process follows the crystal-formation route of pre-nucleation cluster aggregation of particles larger than 500 microns. However, due to their large size, current synthesis methods may have limited efficiency, scalability, and particle uniformity. The development of new technologies for producing nano- and microparticles in biomedicine is interesting for various reasons. In this context, a microfluidic-based biomineralization technology is developed, with distinct microfluidic parameters altered, and the chip architecture allows for fine manipulation of the reaction parameters. The obtained reaction conditions yielded a 20-100-micron crystal. Furthermore, this approach enables the straightforward encapsulation of two different model dyes: methylene blue (MB) and rose Bengal (RB). The proposed microfluidic-aided synthesis technique provides a viable route for future study in particle production and medicine delivery systems.

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Fabrication of Biomimetic Hybrid Liposomes via Microfluidic Technology: Homotypic Targeting and Antitumor Efficacy Studies in Glioma Cells

Arduino,

Di Fonte,

Sommonte

et al. 2024

IJN

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Advances in biomimetic nanomaterial delivery systems: harnessing nature's inspiration for targeted drug delivery

Abstract: The properties of nanomaterials make them promising and advantageous for use in drug delivery systems, but challenges arise from the immune system's recognition of exogenous nanoparticles, leading to their clearance and reduced targeting efficiency.

Cited by 5 publications

References 113 publications

Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Synthetic circRNA therapeutics: innovations, strategies, and future horizons

Microfluidic-assisted Biomineralization of Calcium Phosphate: Enhancing Particle Design for Medical and Therapeutic Applications

Fabrication of Biomimetic Hybrid Liposomes via Microfluidic Technology: Homotypic Targeting and Antitumor Efficacy Studies in Glioma Cells

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