Advances in brain imaging of neuropathic pain

Chen, Fu-yong; Wei, Tao; Li, Yongjie

doi:10.1097/00029330-200804010-00015

Cited by 18 publications

(10 citation statements)

References 39 publications

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“…16,17,58,59,70,72,86,92-94 In most pain studies, the ACC appeared to be involved in the affective aspects of pain processing. 16,17,70,72,94 However, our finding of patient GMV decrease is in an ACC subregion involved in emotion, extending into midcingulate cortex areas involved in pain modulation 6 and fear and avoidance. 102 Cluster 2's FC revealed multiple associations, including emotion, cognition, and pain perception.…”

Section: Discussionmentioning

confidence: 99%

“…The thalamus is a pain region 16,93 involved in affective and sensory processes related to pain. 13 Its FC, however, showed only association with action and speech execution.…”

Section: Discussionmentioning

confidence: 99%

“…10,45,46,77 The functional pain network includes somatosensory cortices, ACC, thalamus, insula, basal ganglia, hippocampus, and temporal and parietal cortices. 16,59,86,93 Given the diverse pain literature, unanimous pain network definitions are difficult. Hence, integration of experimental findings 26 and comparisons between studies is imminent.…”

mentioning

confidence: 99%

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Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

Smallwood

Laird

Ramage

et al. 2013

The Journal of Pain

241

217

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The diversity of chronic pain syndromes and the methods employed to study them make integrating experimental findings challenging. This study performed coordinate-based meta-analyses using voxel-based morphometry imaging results to examine gray matter volume (GMV) differences between chronic pain patients and healthy controls. There were 12 clusters where GMV was decreased in patients compared with controls, including many regions thought to be part of the “pain matrix” of regions involved in pain perception, but also including many other regions that are not commonly regarded as pain-processing areas. The right hippocampus and parahippocampal gyrus were the only regions noted to have increased GMV in patients. Functional characterizations were implemented using the BrainMap database to determine which behavioral domains were significantly represented in these regions. The most common behavioral domains associated with these regions were cognitive, affective, and perceptual domains. Because many of these regions are not classically connected with pain and because there was such significance in functionality outside of perception, it is proposed that many of these regions are related to the constellation of comorbidities of chronic pain, such as fatigue and cognitive and emotional impairments. Further research into the mechanisms of GMV changes could provide a perspective on these findings. Perspective Quantitative meta-analyses revealed structural differences between brains of individuals with chronic pain and healthy controls. These differences may be related to comorbidities of chronic pain.

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Section: Discussionmentioning

confidence: 99%

“…The thalamus is a pain region 16,93 involved in affective and sensory processes related to pain. 13 Its FC, however, showed only association with action and speech execution.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

Smallwood

Laird

Ramage

et al. 2013

The Journal of Pain

241

217

View full text Add to dashboard Cite

show abstract

“…In the last decade, an impressive body of data from modern neuroimaging techniques has been gathered on morphological and functional brain changes characteristic for neuropathic pain (Chen et al, 2008;Friebel et al, 2011;May, 2011). Evidence from functional neuroimaging studies in neuropathic pain have revealed increased activation in a widely distributed network (Friebel et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Quantitative meta‐analysis of grey matter anomalies in neuropathic pain

Pan

Zhong

Shang

et al. 2015

European Journal of Pain

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“…Recent reviews of functional-imaging studies (including positron emission tomography) and neuropathic pain are noted [19][20][21][22][23][24].…”

Section: Magnetic Resonance Imaging Of Neuropathic Painmentioning

confidence: 99%

How Close Are We in Utilizing Functional Neuroimaging in Routine Clinical Diagnosis of Neuropathic Pain?

Borsook

Becerra

2011

Curr Pain Headache Rep

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As with many disorders affecting the central nervous system, treatment of chronic pain is fraught with difficulties related to specific diagnosis and measures of treatment efficacy. Given the recent advances that brain-imaging techniques have contributed to our understanding of how chronic pain affects multiple aspects of brain function (including sensory, emotional, cognitive, and modulatory), opportunities to use these approaches in the clinic are clearly a focus of research laboratories around the world. The routine application of brain imaging as a clinical marker of disease state or therapeutic (drug) efficacy would significantly enhance the clinical process by providing objective measures for clinicians and patients.

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Advances in brain imaging of neuropathic pain

Cited by 18 publications

References 39 publications

Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume

Quantitative meta‐analysis of grey matter anomalies in neuropathic pain

How Close Are We in Utilizing Functional Neuroimaging in Routine Clinical Diagnosis of Neuropathic Pain?

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