Advances in Breast Surgery, 2002-2012

Abstract

The past 40 years have brought dramatic changes in breast cancer treatments, resulting in a 30% reduction in breast cancer mortality. This is largely the result of new concepts tested in a steady stream of large, well-designed, coordinated clinical trials. Early trials showed that extended surgery ("local therapy") does not improve mortality over less aggressive surgery. Trials conducted in the 1970s and 1980s clearly showed that radical surgery involving removal of the breast provides no outcome advantage over breast-conserving therapy (BCT). One concern with BCT has been a higher rate of local recurrence compared with mastectomy, with initial studies before the routine use of systemic therapy reporting rates of 10% to 20% with BCT. Modern series define a risk of local recurrence after BCT of 2% to 5%, about the same as with mastectomy. The improvement is partly due to improved standards in surgery, radiation oncology, and pathology. However, it is primarily due to the use of systemic endocrine and chemotherapy. BCT is appropriate for most women with breast cancer. This article explores the advancements in breast surgery over the past 10 years.

Memantine before Mastectomy Prevents Post-Surgery Pain: A Randomized, Blinded Clinical Trial in Surgical Patients

“…Although surgery, radiotherapy and chemotherapy have dramatically increased the life expectancy of patients suffering from breast cancer [ 1 ], these treatments may also induce neuropathic pain. In the course of breast surgery, 20–68% of patients report burning and shooting pain localized in the anterior chest, arm and axilla with numbness and pressure sensation [ 2 ].…”

Effect of Botulinum Toxin A on Proliferation and Apoptosis in the T47D Breast Cancer Cell Line

“…Breast cancer is a heterogeneous disease in terms of gene expression, morphology, clinical course, and response to treatment. Therapeutic options for this breast cancer include surgery, adjuvant chemotherapy, radiotherapy, hormonal therapy or targeted therapy (Kim et al, 2012;Lee et al, 2012;Sendur et al, 2012;Truin et al, 2012;Zhou et al, 2012;Edge, 2013).…”

Treatment Approaches for Breast Cancer in Netherland Cancer Institute

“…lenfosintigrafide mamaria interna (MI) drenajı varsa ve biyopsi sonucunun RT tedavi planını değiştirebileceği düşünülen olgularda MI biyopsisi yapılıyor. Drenaj olmayan hastalarda tümör lokalizasyonuna göre Mİ biyopsisi yapılmıyor (15).…”